Iannis E Adamopoulos

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. ncbi Immune regulation of bone loss by Th17 cells
    Iannis E Adamopoulos
    Department of Immunology, Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA
    Arthritis Res Ther 10:225. 2008
  2. ncbi Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors
    Iannis E Adamopoulos
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, 901 South California Avenue, Palo Alto, CA 94304, USA
    Arthritis Res Ther 12:R29. 2010
  3. ncbi Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis
    Cheng Chi Chao
    Department of Immunology, Merck Palo Alto formerly DNAX Research Institute, Palo Alto, CA 94304, USA
    Autoimmunity 44:243-52. 2011
  4. ncbi IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass
    Iannis E Adamopoulos
    Discovery Research, Merck Research Laboratories, Palo Alto, CA 94304, USA
    J Immunol 187:951-9. 2011
  5. ncbi Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis
    Barbara Joyce-Shaikh
    Department of Discovery Research, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 207:579-89. 2010
  6. ncbi Structural, cellular, and molecular evaluation of bone erosion in experimental models of rheumatoid arthritis: assessment by ?CT, histology, and serum biomarkers
    Cheng Chi Chao
    Department of Immunology, Schering Plough Biopharma formerly DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Autoimmunity 43:642-53. 2010

Collaborators

  • Drake LaFace
  • Nancy E Lane
  • Chuan Chu Chou
  • Daniel J Cua
  • Wei Yao
  • Cheng Chi Chao
  • Edward P Bowman
  • Shi Juan Chen
  • Agelio Asio
  • Barbara Joyce-Shaikh
  • Kyu Hong
  • Nicole Davis
  • Sylvia Kwan
  • Anna Vu
  • Laurence Fayadat-Dilman
  • Wendy M Blumenschein
  • Gulesi Ayanoglu
  • Svetlana Antonenko
  • Michael Judo
  • Joseph H Phillips
  • Erin E Murphy
  • Paul G Heyworth
  • Terrill K McClanahan
  • Michael E Bigler

Detail Information

Publications6

  1. ncbi Immune regulation of bone loss by Th17 cells
    Iannis E Adamopoulos
    Department of Immunology, Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA
    Arthritis Res Ther 10:225. 2008
    ....
  2. ncbi Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors
    Iannis E Adamopoulos
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, 901 South California Avenue, Palo Alto, CA 94304, USA
    Arthritis Res Ther 12:R29. 2010
    ..In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis...
  3. ncbi Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis
    Cheng Chi Chao
    Department of Immunology, Merck Palo Alto formerly DNAX Research Institute, Palo Alto, CA 94304, USA
    Autoimmunity 44:243-52. 2011
    ..These data identify IL-17A as a key factor in inflammation-mediated bone destruction and support anti-IL-17A therapy for the treatment of inflammatory bone diseases such as RA...
  4. ncbi IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass
    Iannis E Adamopoulos
    Discovery Research, Merck Research Laboratories, Palo Alto, CA 94304, USA
    J Immunol 187:951-9. 2011
    ....
  5. ncbi Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis
    Barbara Joyce-Shaikh
    Department of Discovery Research, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 207:579-89. 2010
    ..These findings suggest that MDL-1 receptor may be a therapeutic target for treatment of immune-mediated skeletal disorders...
  6. ncbi Structural, cellular, and molecular evaluation of bone erosion in experimental models of rheumatoid arthritis: assessment by ?CT, histology, and serum biomarkers
    Cheng Chi Chao
    Department of Immunology, Schering Plough Biopharma formerly DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Autoimmunity 43:642-53. 2010
    ..The experimental approaches and concepts outlined in this paper provide a valuable process to evaluate and quantify therapies that modulate rodent arthritis-associated bone-erosion models...