Research Topics
Genomes and Genes | WILLIS SAMSONSummaryAffiliation: Saint Louis University Country: USA Publications
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Publications
A novel action of the newly described prolactin-releasing peptides: cardiovascular regulationW K Samson
Department of Pharmacological and Physiological Sciences, St Louis University School of Medicine, St Louis, MO 63104 1028, USA
Brain Res 858:19-25. 2000....- Central neuropeptide B administration activates stress hormone secretion and stimulates feeding in male ratsW K Samson
Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
J Neuroendocrinol 16:842-9. 2004.... - Non-sleep effects of hypocretin/orexinWillis K Samson
Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Sleep Med Rev 9:243-52. 2005.... - Prolactin releasing peptide (PrRP): an endogenous regulator of cell growthWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Peptides 27:1099-103. 2006.... - Putting the brakes on lactotrope hyperplasiaWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63131, USA
Trends Endocrinol Metab 17:2-3. 2006..These novel findings promise increased knowledge of the genesis and potential therapeutic control of human prolactinomas... - Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stressWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 292:R382-7. 2007..These data suggest receptor subtype-selective responses to hypocretin/orexin and provide further evidence for the importance of endogenously produced peptide in the physiological control of stress hormone secretion... - Obestatin acts in brain to inhibit thirstWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 292:R637-43. 2007..Importantly, in rats the effects of obestatin on food intake may be secondary to an action of the peptide to inhibit water drinking... - Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasisWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
J Endocrinol 196:559-64. 2008..We conclude that this product of post-translational processing of the ghrelin prohormone may be an important contributor to the physiologic regulation of fluid and electrolyte homeostasis... - Hypothalamic localization of steroidogenic acute regulatory protein: the missing piece of the puzzle is foundWillis K Samson
Pharmacological and Physiological Sciences, St Louis University, 1402 South Grand Boulevard, MO 63131, USA
Trends Endocrinol Metab 14:99-100. 2003.... - Prolactin-releasing peptide and its homolog RFRP-1 act in hypothalamus but not in anterior pituitary gland to stimulate stress hormone secretionWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Endocrine 20:59-66. 2003.... - The hypocretin/orexin storyW K Samson
Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63131, USA
Trends Endocrinol Metab 11:257-62. 2000..Neuroendocrine and metabolic effects of these peptides, some related to sleep-wakefulness and arousal state, are just now being discovered... - Hypocretin/orexin suppresses corticotroph responsiveness in vitroW K Samson
Pharmacological and Physiological Sciences, St Louis University School of Medicine, St Louis, Missouri 63104, USA
Am J Physiol Regul Integr Comp Physiol 281:R1140-5. 2001..Our data suggest a direct, pituitary action of the Hcrts/ORXs to modulate the endocrine response to stress and identify the potential cellular mechanism of a unique biological action of the peptides in the anterior pituitary gland... - Orexin actions in hypothalamic paraventricular nucleus: physiological consequences and cellular correlatesWillis K Samson
Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Regul Pept 104:97-103. 2002..0+/-0.6 mV), accompanied by increases in spike frequency in identified magno- and parvocellular neurons in the PVN. Our data suggest a potential role for endogenous orexin in the hypothalamic regulation of stress hormone secretion... - Orexin receptor subtype activation and locomotor behaviour in the ratW K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63131, USA
Acta Physiol (Oxf) 198:313-24. 2010..We describe here the ability of orexin to increase locomotor behaviours and identify the importance of both receptor subtypes in these actions... - Prolactin-releasing peptidesWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Regul Pept 114:1-5. 2003.... - Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functionsWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
J Biol Chem 283:31949-59. 2008..Our findings demonstrate diverse neuronal, neuroendocrine, and cardiovascular actions of a somatostatin gene-encoded hormone and provide the basis to investigate the physiological roles of this endogenously produced brain/gut peptide... - Knockout knockoutsWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Trends Endocrinol Metab 16:1-2. 2005.... - The other side of the orexins: endocrine and metabolic actionsMeghan M Taylor
Pharmacological and Physiological Science, St. Louis University School of Medicine, Missouri 63104, USA
Am J Physiol Endocrinol Metab 284:E13-7. 2003..Thus these pluripotent peptides hold great potential not only for the treatment of human narcolepsy but also to provide insight into the coordinated regulation of multiple physiological systems... - Neuropeptide W acts in brain to control prolactin, corticosterone, and growth hormone releaseJennifer R Baker
Pharmacological and Physiological Sciences, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Endocrinology 144:2816-21. 2003.... - Actions of neuropeptide W in paraventricular hypothalamus: implications for the control of stress hormone secretionMeghan M Taylor
Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 288:R270-5. 2005..Our data suggest that endogenous NPW, produced in brain, may play a physiologically relevant role in the neuroendocrine response to stress... - Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intakeMeghan M Taylor
Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 288:R919-27. 2005..Our data indicate that IMD has potent actions within the CNS that may be a result of the combined activation of both AM and CGRP receptors... - The melanocortins, not oxytocin, mediate the anorexigenic and antidipsogenic effects of neuronostatinGina L C Yosten
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, Saint Louis, MO 63104, USA
Peptides 31:1711-4. 2010..Neuronostatin-induced anorexia was not reversed by pretreatment with the oxytocin receptor antagonist, OVT, suggesting that neuronostatin acts through a unique subset of POMC neurons that do not signal via central oxytocin receptors... - The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonistGina L C Yosten
Department of Pharmacological and Physiological Science, Saint Louis University, Saint Louis, Missouri 63104, USA
Am J Physiol Regul Integr Comp Physiol 298:R1642-7. 2010.... - Adrenomedullin and the integrative physiology of fluid and electrolyte balanceMeghan M Taylor
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
Microsc Res Tech 57:105-9. 2002..Development of molecular tools to determine the physiologic role of endogenous AM will greatly enhance our understanding of AM and its regulation of fluid and electrolyte homeostasis... - Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin systemGina L C Yosten
Saint Louis Univ, Dept of Pharmacological and Physiological Science, 1402 S Grand Blvd, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 297:R330-6. 2009..Thus we have identified a novel action of nesfatin-1, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity... - Involvement of the central adrenomedullin peptides in the baroreflexMeghan M Taylor
Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Regul Pept 112:87-93. 2003..These findings suggest that endogenous, brain-derived AM and PAMP participate in the regulation of autonomic activity in response to baroreceptor activation and inactivation... - Ribozyme compromise of adrenomedullin mRNA reveals a physiological role in the regulation of water intakeMeghan M Taylor
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
Am J Physiol Regul Integr Comp Physiol 282:R1739-45. 2002.... - Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitaryMeghan M White
Saint Louis University, School of Medicine, Department of Pharmacological and Physiological Science, 1402 S Grand Boulevard, St Louis, MO 63104, USA
Peptides 28:2171-8. 2007..c.v. administration, cause increased water drinking in male rats. This tool may provide a better method than the use of the IMD17-47 compound to study the role of endogenous IMD within the CNS and pituitary... - Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptorsGina L C Yosten
Dept of Pharmacological and Physiological Science, Saint Louis University, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 300:R1194-9. 2011.... - Stress hormone secretion is altered by central administration of intermedin/adrenomedullin-2Meghan M Taylor
Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
Brain Res 1045:199-205. 2005..These results suggest that multiple members of the AM family of peptides may be involved in the cardiovascular, behavioral and neuroendocrine responses to stress... - Intermedin/Adrenomedullin-2 inhibits growth hormone release from cultured, primary anterior pituitary cellsMeghan M Taylor
Saint Louis University, Pharmacological and Physiological Science, Missouri 63104, USA
Endocrinology 147:859-64. 2006.... - A possible mechanism for the action of adrenomedullin in brain to stimulate stress hormone secretionMeghan M Taylor
Saint Louis University, Department of Pharmacological and Physiological Science, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
Endocrinology 145:4890-6. 2004..In addition, AM given intracerebroventricularly stimulated the release of prolactin but did not alter the secretion of GH. We propose that AM produced in the brain may be an important neuromodulator of the hormonal stress response... - Brain-derived adrenomedullin controls blood volume through the regulation of arginine vasopressin production and releaseMeghan M Taylor
Dept of Pharmacological and Physiological Science, Saint Louis Univ, 1402 South Grand Blvd, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 288:R1203-10. 2005..These data suggest that brain-derived AM is a physiological regulator of vasopressin secretion and, thereby, fluid homeostasis... - A possible relationship between brain-derived adrenomedullin and oxytocin in the regulation of sodium balanceMeghan M White
Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63104, USA
J Endocrinol 203:253-62. 2009.... - Closing the link in short-loop prolactin feedbackMeghan M White
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104, USA
Trends Endocrinol Metab 17:217-8. 2006..Short-loop negative feedback actions of prolactin in hypothalamus have been recognized for some time. Two recent papers demonstrate the multiple sites of this feedback action and the signaling mechanisms involved... - Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1Tulin O Price
Geriatric Research, Education, and Clinical Center GRECC, Veteran Affairs Medical Center, St Louis, MO 63106, USA
Peptides 28:2372-81. 2007..Efflux of labeled nesfatin-1 from brain back into blood was by way of bulk flow. These findings demonstrate that nesfatin-1 crosses the BBB in both the blood-to-brain and brain-to-blood directions by nonsaturable mechanisms... - Antisense inhibition: oligonucleotides, ribozymes, and siRNAsY Clare Zhang
Department of Pediatrics, University of South Florida, St. Petersburg, FL, USA
Methods Mol Med 106:11-34. 2005 - Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase CBo Yang
Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3N6
J Neurosci 23:6215-22. 2003..These results therefore show that the excitatory effects of ORX-A on NTS neurons are mediated through activation of the PLC-PKC-NSCC and -IK signaling pathways, which probably result from OXR-coupled activation of Gq... - The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic functionAlastair V Ferguson
Department of Physiology, Queen s University, Kingston, ON, Canada
Front Neuroendocrinol 24:141-50. 2003..This review focuses upon evidence for potential physiologic roles for the peptides in these sites... - The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunctionAlastair V Ferguson
Queen s University, Department of Physiology, Kingston, Ontario, K7L 3N6, Canada
Expert Opin Ther Targets 12:717-27. 2008.... - Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytesFeng Dong
Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071 3375, USA
J Appl Physiol 101:778-84. 2006..Our data suggest that IMD acutely augments cardiomyocyte contractile function through, at least in part, a protein kinase C- and protein kinase A-dependent mechanism...
Research Grants
- PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDESWILLIS SAMSON; Fiscal Year: 2009..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
- PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDESWILLIS SAMSON; Fiscal Year: 2007..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
- Orexinergic Pathways in Central Autonomic ControlWILLIS SAMSON; Fiscal Year: 2005..abstract_text> ..
- PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDESWILLIS SAMSON; Fiscal Year: 2003..These studies will also begin to examine a potentially novel confluence of endocrine and autonomic responses to stress and thereby provide insight into the coordinated responses of multiple organ systems to stress. ..
- PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDESWillis K Samson; Fiscal Year: 2010..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..