G F Merrill

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi Acute coronary vascular and myocardial perfusion effects of conjugated equine estrogen in the anesthetized dog
    N A McHugh
    State University of New Jersey, FAS Division of Life Sciences, Piscataway 08854 8083, USA
    Basic Res Cardiol 93:470-6. 1998
  2. ncbi Coronary and myocardial effects of acetaminophen: protection during ischemia-reperfusion
    G Merrill
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Am J Physiol Heart Circ Physiol 280:H2631-8. 2001
  3. ncbi Antioxidant properties of acetaminophen and cardioprotection
    G F Merrill
    Department of Cell Biology and Neurosciences, Rutgers University, Piscataway, NJ 08854 8082, USA
    Basic Res Cardiol 96:423-30. 2001
  4. ncbi Antiarrhythmic properties of acetaminophen in the dog
    Gary F Merrill
    Division of Life Sciences, Department of Cell Biology and Neurosciences, Rutgers University, Piscataway, New Jersey 08854, USA
    Exp Biol Med (Maywood) 232:1245-52. 2007
  5. ncbi Acetaminophen and myocardial infarction in dogs
    Gary F Merrill
    Department of Cell Biology and Neurosciences, Division of Life Sciences, Rutgers Univ, 604 Allison Rd, Piscataway, NJ 08854, USA
    Am J Physiol Heart Circ Physiol 287:H1913-20. 2004
  6. ncbi An old drug with a new purpose: cardiovascular actions of acetaminophen (paracetamol)
    Norell M Spiler
    Department of Cell Biology and Neuroscience, Division of Life Sciences, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:419-29. 2005
  7. ncbi Chronically administered acetaminophen and the ischemia/reperfused myocardium
    R Golfetti
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
    Exp Biol Med (Maywood) 228:674-82. 2003
  8. ncbi Acetaminophen in the hypoxic and reoxygenated guinea pig myocardium
    Tyler H Rork
    Division of Life Sciences, Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Rd, Piscataway, NJ 08854, USA
    Exp Biol Med (Maywood) 229:1154-61. 2004
  9. ncbi Acetaminophen and low-flow myocardial ischemia: efficacy and antioxidant mechanisms
    Gary F Merrill
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Am J Physiol Heart Circ Physiol 282:H1341-9. 2002
  10. ncbi Acetaminophen is cardioprotective against H2O2-induced injury in vivo
    Kathryn M Jaques-Robinson
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    Exp Biol Med (Maywood) 233:1315-22. 2008

Collaborators

  • Tyler H Rork
  • Norell M Hadzimichalis
  • Norell M Spiler
  • Kathryn M Jaques-Robinson
  • Sunanda S Baliga
  • Roseli Golfetti
  • R Golfetti
  • Bonnie L Firestein
  • Kathryn M Jaques
  • N A McHugh
  • Maya A Kappil
  • Knox Van Dyke
  • T Rork
  • A Solowiej
  • R E Klabunde

Detail Information

Publications12

  1. ncbi Acute coronary vascular and myocardial perfusion effects of conjugated equine estrogen in the anesthetized dog
    N A McHugh
    State University of New Jersey, FAS Division of Life Sciences, Piscataway 08854 8083, USA
    Basic Res Cardiol 93:470-6. 1998
    ..We conclude that the acute, systemic administration of estrogen in the anesthetized dog decreases regional perfusion in the ischemic myocardium and causes significant coronary vaso-constriction when flow is controlled and limited...
  2. ncbi Coronary and myocardial effects of acetaminophen: protection during ischemia-reperfusion
    G Merrill
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Am J Physiol Heart Circ Physiol 280:H2631-8. 2001
    ....
  3. ncbi Antioxidant properties of acetaminophen and cardioprotection
    G F Merrill
    Department of Cell Biology and Neurosciences, Rutgers University, Piscataway, NJ 08854 8082, USA
    Basic Res Cardiol 96:423-30. 2001
    ..Collectively these data reveal cardioprotective, antioxidant behavior of acetaminophen. Under selected conditions (e.g. those causing release of free radicals and other oxidants) such behavior might also prevent ventricular arrhythmias...
  4. ncbi Antiarrhythmic properties of acetaminophen in the dog
    Gary F Merrill
    Division of Life Sciences, Department of Cell Biology and Neurosciences, Rutgers University, Piscataway, New Jersey 08854, USA
    Exp Biol Med (Maywood) 232:1245-52. 2007
    ..Similar results were obtained with ouabain. Our results reveal that systemic administration of a therapeutic dose of acetaminophen has previously unreported antiarrhythmic effects in the dog...
  5. ncbi Acetaminophen and myocardial infarction in dogs
    Gary F Merrill
    Department of Cell Biology and Neurosciences, Division of Life Sciences, Rutgers Univ, 604 Allison Rd, Piscataway, NJ 08854, USA
    Am J Physiol Heart Circ Physiol 287:H1913-20. 2004
    ..They suggest that it is necessary to add acetaminophen to the growing list of pharmaceuticals that possess cardioprotective efficacy in mammals...
  6. ncbi An old drug with a new purpose: cardiovascular actions of acetaminophen (paracetamol)
    Norell M Spiler
    Department of Cell Biology and Neuroscience, Division of Life Sciences, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:419-29. 2005
    ..Such work is needed to either challenge or support our findings. Further, more clinically-relevant work depends on these basic and related translational experiments...
  7. ncbi Chronically administered acetaminophen and the ischemia/reperfused myocardium
    R Golfetti
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854-8082, USA
    Exp Biol Med (Maywood) 228:674-82. 2003
    ..We conclude that chronic administration of acetaminophen provides cardioprotection to the postischemic, reperfused rodent myocardium...
  8. ncbi Acetaminophen in the hypoxic and reoxygenated guinea pig myocardium
    Tyler H Rork
    Division of Life Sciences, Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Rd, Piscataway, NJ 08854, USA
    Exp Biol Med (Maywood) 229:1154-61. 2004
    ..05). We conclude that acetaminophen has previously unreported cardioprotective properties in the nonischemic, hypoxic, and reoxygenated myocardium mediated through the reduction of reactive oxygen species...
  9. ncbi Acetaminophen and low-flow myocardial ischemia: efficacy and antioxidant mechanisms
    Gary F Merrill
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Am J Physiol Heart Circ Physiol 282:H1341-9. 2002
    ....
  10. ncbi Acetaminophen is cardioprotective against H2O2-induced injury in vivo
    Kathryn M Jaques-Robinson
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    Exp Biol Med (Maywood) 233:1315-22. 2008
    ..We conclude that, in the canine myocardium, acetaminophen is both functionally cardioprotective and antiarrhythmic against H(2)O(2)-induced oxidative injury...
  11. ncbi Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium
    Tyler H Rork
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    J Mol Cell Cardiol 40:553-61. 2006
    ..We conclude that acetaminophen is cardioprotective, at least in part, by attenuating peroxynitrite-activated, MMP-2-mediated cleavage of TnI...
  12. ncbi Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway
    Norell M Hadzimichalis
    Department of Cell Biology and Neuroscience, Division of Life Sciences, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Am J Physiol Heart Circ Physiol 293:H3348-55. 2007
    ..These data, together with electron micrograph analysis, suggest that acetaminophen mediates cardioprotection, in part, via inhibition of the mitochondrial permeability transition pore and subsequent apoptotic pathway...