Research Topics
| Catherine LawsonSummaryAffiliation: Rutgers University Country: USA Publications
Research Grants
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Detail Information
Publications
EMDataBank.org: unified data resource for CryoEMCatherine L Lawson
Department of Chemistry and Chemical Biology and Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, 610 Taylor Road Piscataway, NJ 08854, USA
Nucleic Acids Res 39:D456-64. 2011....- Signatures of protein-DNA recognition in free DNA binding sitesJason W Locasale
Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA
J Mol Biol 386:1054-65. 2009..Together, our findings show that crystal structures of free DNA binding sites provide new information about the nature of protein-DNA interactions and thus lend insights towards a structural code for DNA recognition... - Catabolite activator protein: DNA binding and transcription activationCatherine L Lawson
Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA
Curr Opin Struct Biol 14:10-20. 2004.... - Representation of viruses in the remediated PDB archiveCatherine L Lawson
RCSB Protein Data Bank, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 8087, USA
Acta Crystallogr D Biol Crystallogr . 2008..Complete correct information for building full assemblies, subassemblies and crystal asymmetric units of all virus entries is now available in the remediated PDB archive... - E. coli trp repressor forms a domain-swapped array in aqueous alcoholCatherine L Lawson
Rutgers University, Department of Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, USA
Structure 12:1099-108. 2004..Small angle X-ray scattering measurements show that the self-association properties of trpR in solution are fundamentally altered by isopropanol... - Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicataeCatherine L Lawson
Department of Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, USA
J Bacteriol 188:4522-30. 2006.... - Structural basis of transcription activation: the CAP-alpha CTD-DNA complexBrian Benoff
Waksman Institute and Department of Chemistry, Howard Hughes Medical Institute, Rutgers University, Piscataway, NJ 08854, USA
Science 297:1562-6. 2002..These findings are consistent with the proposal that activation involves a simple "recruitment" mechanism... - Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine stepsAndrew A Napoli
Department of Chemistry and Chemical Biology and Waksman Institute Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Mol Biol 357:173-83. 2006.... - A structure-based method for identifying DNA-binding proteins and their sites of DNA-interactionWilliam A McLaughlin
Department of Chemistry and Chemical Biology, Rutgers-The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854-8087, USA
J Struct Funct Genomics 5:255-65. 2004..For each of the candidate structures, possible sites of DNA-binding are indicated by listing the residue ranges of alpha helices likely to interact with DNA... - Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domainSamuel Lara-Gonzalez
Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA
Acta Crystallogr D Biol Crystallogr 66:806-12. 2010..The new coordinates will facilitate the improved modeling of alphaCTD-containing multi-component complexes visualized at lower resolution using X-ray crystallography and electron-microscopy reconstruction... - Three-dimensional EM structure of an intact activator-dependent transcription initiation complexBrian P Hudson
Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 106:19830-5. 2009..The structure also reveals the positions and shapes of species-specific domains within the RNAP beta', beta, and sigma(70) subunits... - Biophysical characterization of natural and mutant fluorescent proteins cloned from zooxanthellate coralsYi Sun
Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers University, 71 Dudley Road, New Brunswick, NJ 08901, USA
FEBS Lett 570:175-83. 2004..Time-resolved emission lifetimes and anisotropies suggest that the electronic structure of the chromophore is highly dependent on the protonation state of adjoining residues... - Crystals of trp repressor suitable for high-resolution neutron Laue diffraction studiesBrenda V Daniels
Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Acta Crystallogr D Biol Crystallogr 59:136-8. 2003..Direct observation of hydrogen bonding between protein and solvent should enhance understanding of the role of solvent in protein-DNA recognition... - Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab targetMichael Becker
Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Biol Chem 280:17363-70. 2005..OspB structure, stability, and possible mechanisms of killing by H6831 and other bactericidal Fabs are discussed in light of the structural data... - Approaches toward the directed design of a vaccine against Borrelia burgdorferiBenjamin J Luft
Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8160, USA
J Infect Dis 185:S46-51. 2002..Detailed epitope mapping will provide the information needed for the bioengineering of antigens needed to expand the specificity of a candidate vaccine... - Remediation of the protein data bank archiveKim Henrick
MSD EBI, EMBL Outstation Hinxton, Cambridge CB10 1SD, UK
Nucleic Acids Res 36:D426-33. 2008..The scope and methods used in this project are presented... - Design of a data model for developing laboratory information management and analysis systems for protein productionAnne Pajon
EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
Proteins 58:278-84. 2005..The model is described in Unified Modeling Language (UML). In addition, we present relational database schemas derived from the UML. These relational schemas are already in use in a number of data management projects... - Residual brain infection in relapsing-fever borreliosisDiego Cadavid
Department of Neurology and Neuroscience and Center for the Study of Emerging Pathogens, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103, USA
J Infect Dis 193:1451-8. 2006..Less understood is the persistence of RF borreliae in the brain after they are cleared from the blood, referred to as residual brain infection (RBI). Our goal was to investigate the phenomenon of RBI in RF...
Research Grants
- BIOMOLECULAR STRUCTURE AND INTERACTIONSCatherine Lawson; Fiscal Year: 2003..In addition, we are determining the structures of selected oligonucleotides in an attempt to understand the effects of sequence and environment on DNA structure. ..
- Complexes of CAP in Transcription ActivationCatherine Lawson; Fiscal Year: 2009..The proposed studies of the CAP system provide a means to rapidly advance our understanding of fundamental structural principles underlying transcriptional control. ..