M C Morris

..High intake of vitamin E from food (tocopherol), but not from supplements (which usually contain alpha-tocopherol), is inversely associated with Alzheimer disease...

..Further, these studies must be particularly focused on the levels of nutrient intake or status that confer optimum or suboptimal brain functioning...

..We examined whether dietary intake of niacin was associated with incident Alzheimer's disease (AD) and cognitive decline in a large, prospective study...

..To examine whether consumption of different types of fat is associated with age-related change in cognition...

..Deficiencies in folate and vitamin B12 have been associated with neurodegenerative disease...

..Dietary intake of fish and the omega-3 fatty acids have been associated with lower risk of Alzheimer disease and stroke...

..Evidence from prospective epidemiologic studies and animal models suggests that intakes of dietary fats and copper may be associated with neurodegenerative diseases...

..To examine the association between rates of cognitive change and dietary consumption of fruits and vegetables among older persons...

..CONCLUSION: In this community population where BP treatment was common, there was no association of either high systolic or high diastolic BP at the beginning of the observation interval with 6-year cognitive decline...

..However, the association of cognitive activity with cognitive decline, the principal manifestation of AD, is not well understood...

..The relation of blood pressure to Alzheimer's disease (AD) is complex because both an association of high blood pressure with increased risk of the disease and lower blood pressure as a consequence of the disease are possible...

..Information regarding the prevalence of dizziness and its association with functional disability among African American and white residents from defined community populations is limited...

..To examine whether a higher body mass index (BMI) in older adults is associated with greater cognitive decline...

..Participation in cognitively stimulating activities is hypothesized to be associated with risk of AD, but knowledge about this association is limited...

..To investigate the interrelations of serum vitamin B12 markers with brain volumes, cerebral infarcts, and performance in different cognitive domains in a biracial population sample cross-sectionally...

..It is uncertain whether high blood pressure increases the risk of developing Alzheimer disease (AD)...

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..This review will focus on epidemiological evidence investigating the relationship between nutrition and AD, focusing particularly on the roles of dietary fats and antioxidants...

..It is currently not known whether dietary intakes of folate and vitamins B12 and B6, co-factors in the methylation of homocysteine, protect against Alzheimer's disease...

..The modified Harvard SFFQ is a reasonable method of dietary assessment even in a population of older persons, some of whom are at advanced age, have chronic health conditions, and have cognitive impairment...

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..B-vitamin deficiencies have been associated with depression; however, there is very little prospective evidence from population-based studies of older adults...

..Many of the foods abundant in the traditional Mediterranean diet, such as vegetables and fish, have been associated with slower cognitive decline...

..We also comment on the potential benefits and harms of vitamin supplementation as well as make recommendations for the direction of future studies...

..The cross-sectional association between blood pressure and cognitive functions is small and curvilinear and more apparent in persons with cardiovascular conditions...

..Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease...

..We sought to identify predictors of beginning and ending caregiving...

..Few studies compare Alzheimer disease (AD) incidence among black and white subjects...

..Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases...

..Oxidative processes have been suggested as elements in the development of Alzheimer disease (AD), but whether dietary intake of vitamin E and other antioxidant nutrients prevents its development is unknown...

..Whether or not folic acid supplementation exacerbates neurological symptoms of vitamin B12 deficiency is not clear. Further studies are needed to determine the possible risks and benefits of folic acid supplementation in older persons...

..Few studies have investigated the effects of dietary fats on the development of Alzheimer disease. We examined the associations between intake of specific types of fat and incident Alzheimer disease in a biracial community study...

..CONCLUSIONS: These cross-sectional analyses offer promising evidence that this common condition is correlated with the presence of certain conditions (e.g., stroke and diabetes) and use of certain psychoactive medications...