Research Topics
| K N LohrSummaryAffiliation: RTI International Country: USA Publications
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Detail Information
Publications
Health policy issues and applications for evidence-based medicine and clinical practice guidelinesK N Lohr
Research Triangle Institute, Research Triangle Park, NC 27709, USA
Health Policy 46:1-19. 1998..The methods and information generated from evidence-based guidelines efforts are critical inputs into health policy analysis and decision-making...- Rating the strength of scientific evidence: relevance for quality improvement programsKathleen N Lohr
RTI International, 3040 Cornwallis Drive, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
Int J Qual Health Care 16:9-18. 2004.... - Emerging methods in comparative effectiveness and safety: symposium overview and summaryKathleen N Lohr
RTI International, Research Triangle Park, North Carolina, USA
Med Care 45:S5-8. 2007.... - Using patient-reported outcomes in clinical practice: challenges and opportunitiesKathleen N Lohr
Social and Statistical Sciences, RTI International, 3040 Cornwallis Road, P O Box 12194, Research Triangle Park, NC 27709 2194, USA
Qual Life Res 18:99-107. 2009..Introduce and explore issues at an international conference about the use of patient-reported outcomes (PROs) in clinical practice... - Comparative effectiveness research methods: symposium overview and summaryKathleen N Lohr
RTI International, Research Triangle Park, NC 27709 2194, USA
Med Care 48:S3-6. 2010..Finally, some articles provided guidance for and examples of extending CER into newer realms, such as evaluations of medical devices or surgical procedures, and providing better information for decision-makers, clinicians, and patients... - Assessing "best evidence": issues in grading the quality of studies for systematic reviewsK N Lohr
Research Triangle Institute, Research Triangle Park, NC 27709 1294, USA
Jt Comm J Qual Improv 25:470-9. 1999..Clinicians, program administrators, and health policymakers can then be confident in the overall strength of the evidence and study conclusions... - Health outcomes methodology symposium: summary and recommendationsK N Lohr
Health Services and Policy Research Program, Research Triangle Institute, Research Triangle Park, North Carolina, USA
Med Care 38:II194-208. 2000..Interest in the philosophy and techniques of the assessment of health outcomes has burgeoned, prompting research funding agencies and others to examine traditional and emerging methods for outcome measurement... - Outcomes and costs of community health worker interventions: a systematic reviewMeera Viswanathan
RTI International, Research Triangle Park, NC 27709 2194, USA
Med Care 48:792-808. 2010..We conducted a systematic review on outcomes and costs of community health worker (CHW) interventions. CHWs are increasingly expected to improve health outcomes cost-effectively for the underserved... - Perinatal depression: a systematic review of prevalence and incidenceNorma I Gavin
RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
Obstet Gynecol 106:1071-83. 2005..We systematically review evidence on the prevalence and incidence of perinatal depression and compare these rates with those of depression in women at non-childbearing times... - Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic reviewArthur J Bonito
Program on Health Care Organization, Delivery and Access, Health, Social, and Economic Research, Research Triangle Institute International, Research Triangle Park, NC 27709 2194, USA
J Periodontol 76:1227-36. 2005..Primary outcomes considered are reductions in probing depth (PD) and gains in clinical attachment level (CAL)... - Communication message strategies for increasing knowledge about prostate cancer screeningLauren A McCormack
RTI International, Research Triangle Park, NC 27709, USA
J Cancer Educ 24:238-43. 2009..This community-based intervention study examined the effects of 2 different message strategies for presenting information about the prostate specific antigen (PSA) test... - Screening and treating adults for lipid disordersM P Pignone
Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Prev Med 20:77-89. 2001.... - Applying cognitive design principles to formatting HRQOL instrumentsP A Mullin
Research Triangle Institute, Research Triangle Park, NC 27709 2194, USA
Qual Life Res 9:13-27. 2000.... - Health services research: an evolving definition of the fieldKathleen N Lohr
Research Triangle Institute, Research Triangle Park, NC 27709-2194, USA
Health Serv Res 37:7-9. 2002 - Literacy and health outcomes: a systematic review of the literatureDarren A DeWalt
RTI International University of North Carolina Evidence based Practice Center, Research Triangle Park, NC 27599, USA
J Gen Intern Med 19:1228-39. 2004..To review the relationship between literacy and health outcomes... - Tocolytic treatment for the management of preterm labor: a review of the evidenceNancy D Berkman
Research Triangle Institute, Research Triangle Park, NC, USA
Am J Obstet Gynecol 188:1648-59. 2003..Continued maintenance tocolytic therapy has little or no value... - A simple and valid tool distinguished efficacy from effectiveness studiesGerald Gartlehner
University of North Carolina at Chapel Hill, Cecil G Sheps Center for Health Services Research, NC 27599, USA
J Clin Epidemiol 59:1040-8. 2006..To propose and test a simple instrument based on seven criteria of study design to distinguish effectiveness (pragmatic) from efficacy (explanatory) trials... - Assessing the need to update prevention guidelines: a comparison of two methodsGerald Gartlehner
Cecil G Sheps Center for Health Services Research, University of North Carolina, 725 Airport Road, Chapel Hill, NC 27599 7590, USA
Int J Qual Health Care 16:399-406. 2004..Recently, Shekelle and colleagues proposed a model of limited literature searches with modest expert involvement as a way to reduce the cost and time requirements for assessing whether a guideline needs updating... - Screening and interventions for obesity in adults: summary of the evidence for the U.S. Preventive Services Task ForceKathleen M McTigue
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Ann Intern Med 139:933-49. 2003..Pharmacotherapy appears safe in the short term; long-term safety has not been as strongly established. In selected patients, surgery promotes large amounts of weight loss with rare but sometimes severe complications... - How to develop a business case for qualityKristin L Reiter
Department of Health Policy and Administration, 1104H McGavran Greenberg Hall, CB 7411, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7411, USA
Int J Qual Health Care 19:50-5. 2007..To describe the steps in developing a business case for quality-enhancing interventions (QEIs) in health care... - Screening for colorectal cancer in adults at average risk: a summary of the evidence for the U.S. Preventive Services Task ForceMichael Pignone
University of North Carolina at Chapel Hill, Department of Medicine and Cecil Sheps Center for Health Services Research, 5039 Old Clinic Building, CB #7110, Chapel Hill, NC 27599, USA
Ann Intern Med 137:132-41. 2002..Several available screening options seem to be effective, but the single best screening approach cannot be determined because data are insufficient... - Bulimia nervosa treatment: a systematic review of randomized controlled trialsJennifer R Shapiro
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
Int J Eat Disord 40:321-36. 2007.... - Binge eating disorder treatment: a systematic review of randomized controlled trialsKimberly A Brownley
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
Int J Eat Disord 40:337-48. 2007.... - Anorexia nervosa treatment: a systematic review of randomized controlled trialsCynthia M Bulik
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
Int J Eat Disord 40:310-20. 2007.... - Biologics for the treatment of juvenile idiopathic arthritis: a systematic review and critical analysis of the evidenceGerald Gartlehner
Ludwig Boltzmann Institute for Health Technology Assessments, Garnisongasse 7 20, 1090, Vienna, Austria
Clin Rheumatol 27:67-76. 2008..Clinicians have to be aware of the lack of evidence supporting a long-term net benefit when considering biologics for patients with JIA... - Antibiotic therapy for the treatment of preterm labor: a review of the evidenceJohn M Thorp
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill 27599-7570, USA
Am J Obstet Gynecol 186:587-92. 2002..CONCLUSION: Treatment of preterm labor with antibiotic therapy can prolong gestation. The benefits of antibiotics are small, and there is considerable uncertainty about the optimal agent, route, dosage, and duration of therapy... - Efficacy and tolerability of second-generation antidepressants in social anxiety disorderRichard A Hansen
Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Int Clin Psychopharmacol 23:170-9. 2008..Overall, a fair amount of evidence supports the efficacy of escitalopram, fluvoxamine, paroxetine, sertraline, and venlafaxine in social anxiety disorder. The drugs do not differ in efficacy, although their adverse event profiles do... - Chemoprevention of breast cancer: a summary of the evidence for the U.S. Preventive Services Task ForceLinda S Kinsinger
Cecil G. Sheps Center for Health Services Research, Program on Prevention, CB# 7508, Wing D, Room 383, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7508, USA
Ann Intern Med 137:59-69. 2002..The absolute risk reduction varies by risk factors for breast cancer, however, and must be balanced against the potential harms to judge the appropriateness of treatment for individual women... - The efficacy of behavioral interventions to modify dietary fat and fruit and vegetable intake: a review of the evidenceAlice S Ammerman
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
Prev Med 35:25-41. 2002..A secondary goal was to explore the relative effectiveness of specific intervention features and among different population subgroups... - Screening for depression in adults: a summary of the evidence for the U.S. Preventive Services Task ForceMichael P Pignone
University of North Carolina Hospitals, Chapel Hill, USA
Ann Intern Med 136:765-76. 2002..CONCLUSION: Compared with usual care, screening for depression can improve outcomes, particularly when screening is coupled with system changes that help ensure adequate treatment and follow-up... - Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task ForceMalaz Boustani
Indiana University School of Medicine, Indianapolis, Indiana, USA
Ann Intern Med 138:927-37. 2003..The effect of cholinesterase inhibitors or other treatments on persons with dementia detected by screening is uncertain... - Efficacy and safety of inhaled corticosteroids in patients with COPD: a systematic review and meta-analysis of health outcomesGerald Gartlehner
Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Ann Fam Med 4:253-62. 2006..We wanted to review systematically the efficacy, effectiveness, and safety of inhaled corticosteroids with respect to health outcomes in patients with chronic obstructive pulmonary disease (COPD)... - Pharmacologic treatment of bronchiolitis in infants and children: a systematic reviewValerie J King
Cecil B. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, 725 Airport Road, Campus Box 7590, Chapel Hill, NC 27599-7595, USA
Arch Pediatr Adolesc Med 158:127-37. 2004..A sufficiently large, well-designed pragmatic trial of the commonly used interventions for bronchiolitis is needed to determine the most effective treatment strategies for managing this condition... - Screening adults for type 2 diabetes: a review of the evidence for the U.S. Preventive Services Task ForceRussell Harris
Sheps Center for Health Services Research, 725 Airport Road, CB # 7590, Chapel Hill, NC 27599-2949, USA
Ann Intern Med 138:215-29. 2003..The magnitude of additional benefit of initiating tight glycemic control during the preclinical phase is uncertain but probably small... - Screening for suicide risk in adults: a summary of the evidence for the U.S. Preventive Services Task ForceBradley N Gaynes
University of North Carolina at Chapel Hill, Chapel Hill 27599, USA
Ann Intern Med 140:822-35. 2004..CONCLUSION: Because of the complexity of studying the risk for suicide and the paucity of well-designed research studies, only limited evidence guides the primary care clinician's assessment and management of suicide risk... - Counseling to promote a healthy diet in adults: a summary of the evidence for the U.S. Preventive Services Task ForceMichael P Pignone
Division of General Internal Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA
Am J Prev Med 24:75-92. 2003..The purpose of this study was to examine the effectiveness of counseling to promote a healthy diet among patients in primary care settings... - Discontinuation rates for selective serotonin reuptake inhibitors and other second-generation antidepressants in outpatients with major depressive disorder: a systematic review and meta-analysisGerald Gartlehner
Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599, USA
Int Clin Psychopharmacol 20:59-69. 2005.... - The insufficiency of evidence to establish the business case for qualityKerry E Kilpatrick
University of North Carolina at Chapel Hill, Department of Health Policy and Administration, Chapel Hill, NC 27599 7411, USA
Int J Qual Health Care 17:347-55. 2005..To determine whether a positive financial return on investment for quality-enhancing interventions is more likely for particular health conditions, in specific organizational settings, or with the use of particular interventions... - Interventions to improve health outcomes for patients with low literacy. A systematic reviewMichael Pignone
Division of General Internal Medicine and Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC, USA
J Gen Intern Med 20:185-92. 2005..To perform a systematic review of interventions designed to improve health outcomes for persons with low literacy skills... - Challenges in systematic reviews of economic analysesMichael Pignone
University of North Carolina, Chapel Hill, North Carolina 27599 7110, USA
Ann Intern Med 142:1073-9. 2005..S. Preventive Services T ask Force, particularly our systematic review of the cost-effectiveness of colorectal cancer screening, to illustrate key methodologic challenges and suggest a framework for other researchers in this area... - Efficacy and safety of second-generation antidepressants in the treatment of major depressive disorderRichard A Hansen
Division of Pharmaceutical Policy and Evaluative Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Ann Intern Med 143:415-26. 2005.... - Screening for prostate cancer: an update of the evidence for the U.S. Preventive Services Task ForceRussell Harris
Cecil G. Sheps Center for Health Services Research, CB# 7590, University of North Carolina School of Medicine, 725 Airport Road, Chapel Hill, NC 27599-7590, USA
Ann Intern Med 137:917-29. 2002..CONCLUSIONS: Although potential harms of screening for prostate cancer can be established, the presence or magnitude of potential benefits cannot. Therefore, the net benefit of screening cannot be determined... - The comparative efficacy and safety of biologics for the treatment of rheumatoid arthritis: a systematic review and metaanalysisGerald Gartlehner
Cecil G Sheps Center for Health Services, and School of Public Health, Health Policy and Administration, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Rheumatol 33:2398-408. 2006..In addition, dosing regimens and routes of administration differ substantially among biologics. In a systematic review, we assessed the comparative efficacy and safety of biologic agents for RA...