C E Cook

Summary

Affiliation: RTI International
Country: USA

Publications

  1. ncbi 7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties
    C Edgar Cook
    Organic and Medicinal Chemistry, Science and Engineering Group, Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709, USA
    Bioorg Med Chem Lett 15:1213-6. 2005
  2. ncbi Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones
    C E Cook
    Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Org Lett 3:1013-6. 2001
  3. ncbi 28-day toxicology test: indenopyridine RTI 4587-056 in male Sprague-Dawley rats
    P A Fail
    Chemistry and Life Sciences Unit, Research Triangle Institute, P O Box 12194, Research Triangle Park, NC 27709 2194, USA
    Reprod Toxicol 14:265-74. 2000
  4. ncbi Preparation of monoclonal antibodies reactive to the endogenous small molecule, anandamide
    Patricia V Basta
    Proteomics Research Group, Science and Engineering, RTI International, P O Box 12194, Research Triangle Park, NC 27709 2194, USA
    J Immunol Methods 285:181-95. 2004
  5. ncbi Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids
    Chunyang Jin
    Organic and Medicinal Chemistry, Science and Engineering Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    Org Lett 9:1887-90. 2007
  6. ncbi Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities
    Chunyang Jin
    Center for Organic and Medicinal Chemistry, RTI International, PO Box 12194, Research Triangle Park, NC 27709, USA
    Bioorg Med Chem Lett 17:5754-7. 2007
  7. ncbi 17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities
    Scott P Runyon
    Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    Eur J Pharmacol 617:68-73. 2009
  8. ncbi Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion
    Ganesan Sathya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 63:8029-36. 2003
  9. ncbi Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins
    Ganesan Sathya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Endocrinology 143:3071-82. 2002
  10. ncbi Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators
    Dmitri Kazmin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 20:1201-17. 2006

Collaborators

Detail Information

Publications10

  1. ncbi 7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties
    C Edgar Cook
    Organic and Medicinal Chemistry, Science and Engineering Group, Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709, USA
    Bioorg Med Chem Lett 15:1213-6. 2005
    ....
  2. ncbi Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones
    C E Cook
    Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Org Lett 3:1013-6. 2001
    ....
  3. ncbi 28-day toxicology test: indenopyridine RTI 4587-056 in male Sprague-Dawley rats
    P A Fail
    Chemistry and Life Sciences Unit, Research Triangle Institute, P O Box 12194, Research Triangle Park, NC 27709 2194, USA
    Reprod Toxicol 14:265-74. 2000
    ..Based upon the Spermatogenic Index ratings, still lower doses would be effective male contraceptive agents. RTI 4587-056 has potential as a male contraceptive without overt side effects. Further testing is required...
  4. ncbi Preparation of monoclonal antibodies reactive to the endogenous small molecule, anandamide
    Patricia V Basta
    Proteomics Research Group, Science and Engineering, RTI International, P O Box 12194, Research Triangle Park, NC 27709 2194, USA
    J Immunol Methods 285:181-95. 2004
    ..2-3 microM) indicate that improvement in antibody affinities or assay format will be required for an immunoassay to measure endogenous levels. Such work is underway...
  5. ncbi Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids
    Chunyang Jin
    Organic and Medicinal Chemistry, Science and Engineering Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    Org Lett 9:1887-90. 2007
    ..The best result was obtained with a catalytic amount of CuI in 1:1 benzene-Et3N at 90 degrees C for 30 min (Ar = 3,4-difluorophenyl; R = ethyl; 97% yield)...
  6. ncbi Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities
    Chunyang Jin
    Center for Organic and Medicinal Chemistry, RTI International, PO Box 12194, Research Triangle Park, NC 27709, USA
    Bioorg Med Chem Lett 17:5754-7. 2007
    ..Some of the compounds showed highly potent, and more selective antiprogestational activity against antiglucocorticoid activity than mifepristone (RU 486)...
  7. ncbi 17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities
    Scott P Runyon
    Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    Eur J Pharmacol 617:68-73. 2009
    ..We conclude that nitro can serve as a bioisostere for acetyl at the 17beta-position of 5alpha-androstan-3alpha-ol, such that the nitro analog fully retains the bioactivity of the endogenous neurosteroid at GABA(A) receptors...
  8. ncbi Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion
    Ganesan Sathya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 63:8029-36. 2003
    ..The unexpected finding that AR-mediated transcription and proliferation can be uncoupled suggests that AR is not used in the same manner in all androgen-regulated biological processes...
  9. ncbi Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins
    Ganesan Sathya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Endocrinology 143:3071-82. 2002
    ..It is anticipated that the availability of these new antiprogestins will advance the studies of PR pharmacology in a manner similar to how the availability of selective ER modulators has helped the study of ER action...
  10. ncbi Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators
    Dmitri Kazmin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 20:1201-17. 2006
    ..This relationship provides a firm underpinning for mechanism-based screens aimed at identifying SARMs with useful clinical profiles...