Kennon J Heard

Summary

Affiliation: Rocky Mountain Poison and Drug Center
Country: USA

Publications

  1. ncbi The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study
    E K Kuffner
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Med 5:13. 2007
  2. ncbi Massive acetylcysteine overdose associated with cerebral edema and seizures
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    Clin Toxicol (Phila) 49:423-5. 2011
  3. ncbi Asymptomatic alanine aminotransferase elevations with therapeutic doses of acetaminophen
    Kennon Heard
    Rocky Mountain Poison Center, 990 Bannock St, Denver, CO 80262, USA
    Clin Toxicol (Phila) 49:90-3. 2011
  4. ncbi Benzodiazepines and antipsychotic medications for treatment of acute cocaine toxicity in animal models--a systematic review and meta-analysis
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver, CO 80204, USA
    Hum Exp Toxicol 30:1849-54. 2011
  5. ncbi Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
  6. ncbi The effect of olanzapine pretreatment on acute cocaine toxicity in mice
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Clin Toxicol (Phila) 47:542-4. 2009
  7. ncbi Case reports describing treatments in the emergency medicine literature: missing and misleading information
    Tiffany P Richason
    The Colorado Emergency Medicine Research Center, Division of Emergency Medicine, Department of Surgery, University of Colorado School Denver of Medicine, Aurora CO, USA
    BMC Emerg Med 9:10. 2009
  8. ncbi Administration of ziprasidone for 10 days increases cocaine toxicity in mice
    K Heard
    Department of Surgery, Division of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA
    Hum Exp Toxicol 27:499-503. 2008
  9. ncbi Acetylcysteine for acetaminophen poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver 80208, USA
    N Engl J Med 359:285-92. 2008
  10. ncbi A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol
    K Heard
    Rocky Mountain Poison and Drug Center, Division of Emergency Medicine, Department of Surgery, University of Colorado Denver and Health Sciences Center, Denver, CO, USA
    Aliment Pharmacol Ther 26:283-90. 2007

Collaborators

Detail Information

Publications18

  1. ncbi The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study
    E K Kuffner
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Med 5:13. 2007
    ..Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects...
  2. ncbi Massive acetylcysteine overdose associated with cerebral edema and seizures
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    Clin Toxicol (Phila) 49:423-5. 2011
    ..Acetylcysteine is a safe and effective treatment for the prevention of hepatic injury due to acetaminophen poisoning. While dosing errors are common, in most cases, overdoses produce minimal clinical effects...
  3. ncbi Asymptomatic alanine aminotransferase elevations with therapeutic doses of acetaminophen
    Kennon Heard
    Rocky Mountain Poison Center, 990 Bannock St, Denver, CO 80262, USA
    Clin Toxicol (Phila) 49:90-3. 2011
    ..Toxicologists should consider therapeutic acetaminophen use as a cause of ALT elevation. Further study of the mechanism of ALT elevations may provide new insight into other causes of drug-induced liver injury and hepatic adaptation...
  4. ncbi Benzodiazepines and antipsychotic medications for treatment of acute cocaine toxicity in animal models--a systematic review and meta-analysis
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver, CO 80204, USA
    Hum Exp Toxicol 30:1849-54. 2011
    ..We conclude that both benzodiazepines and antipsychotic medications are effective for the prevention of lethality from cocaine toxicity in animal models...
  5. ncbi Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
    ..The objective of this study is to describe APAP-CYS concentrations in these clinical settings as well as to further characterize the concentrations observed following acetaminophen overdose...
  6. ncbi The effect of olanzapine pretreatment on acute cocaine toxicity in mice
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Clin Toxicol (Phila) 47:542-4. 2009
    ..Olanzapine, an atypical antipsychotic medication, is an antagonist of these receptors. The objective of this study is to evaluate the efficacy of olanzapine pretreatment for attenuation of acute cocaine toxicity using a mouse model...
  7. ncbi Case reports describing treatments in the emergency medicine literature: missing and misleading information
    Tiffany P Richason
    The Colorado Emergency Medicine Research Center, Division of Emergency Medicine, Department of Surgery, University of Colorado School Denver of Medicine, Aurora CO, USA
    BMC Emerg Med 9:10. 2009
    ..As a result, the information may be misleading to providers, and the clinical applications may be detrimental to patient care...
  8. ncbi Administration of ziprasidone for 10 days increases cocaine toxicity in mice
    K Heard
    Department of Surgery, Division of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA
    Hum Exp Toxicol 27:499-503. 2008
    ..However, our findings suggest that administration of an atypical antipsychotic for 10 days may increase the toxic effects of cocaine...
  9. ncbi Acetylcysteine for acetaminophen poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver 80208, USA
    N Engl J Med 359:285-92. 2008
  10. ncbi A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol
    K Heard
    Rocky Mountain Poison and Drug Center, Division of Emergency Medicine, Department of Surgery, University of Colorado Denver and Health Sciences Center, Denver, CO, USA
    Aliment Pharmacol Ther 26:283-90. 2007
    ..However, 14 days of therapeutic doses of paracetamol has been associated with an increase in serum transaminases...
  11. ncbi Knowledge of treatment group does not bias assessment of time to seizure in an animal model of cocaine poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Acad Emerg Med 17:e75-7. 2010
    ..The necessity of blinded outcome assessment on animal studies is unknown. The authors determined the effect of knowledge of treatment group on assessment of time to seizure in an animal model of cocaine poisoning...
  12. ncbi Serum alanine aminotransferase elevation during 10 days of acetaminophen use in nondrinkers
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, Colorado 80204, USA
    Pharmacotherapy 30:818-22. 2010
    ..To describe the changes in serum alanine aminotransferase (ALT) levels in nondrinkers receiving acetaminophen for 10 days...
  13. ncbi The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, CO 80204, USA
    Aliment Pharmacol Ther 32:478-86. 2010
    ..Metabolism of paracetamol to its hepatotoxic metabolite is enhanced in patients who abuse alcohol, who also have compromised liver defences from depressed hepatic glutathione...
  14. ncbi Dental pain as a risk factor for accidental acetaminophen overdose: a case-control study
    Jody Vogel
    Denver Health Residency in Emergency Medicine, Denver, CO, USA
    Am J Emerg Med 29:1125-9. 2011
    ..Patients frequent take acetaminophen to treat dental pain. One previous study found a high rate of overuse of nonprescription analgesics in an emergency dental clinic...
  15. ncbi Validity of a point of care device (Cholestech LDX) to monitor liver enzyme activity (aminotransferase measures) during a clinical trial
    Jody L Green
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Contemp Clin Trials 31:279-82. 2010
    ..The use of a point of care device to monitor serum transaminases would allow immediate evaluation of this safety endpoint and may be less expensive than standard laboratory testing...
  16. ncbi Types of studies used to support treatment recommendations in medical toxicology
    Ryan Chuang
    Rocky Mountain Poison and Drug Center, 777 Bannock St MC 0180, Denver, CO 80204 4507, USA
    J Med Toxicol 6:345-8. 2010
    ..Case reports and animal studies are commonly used as evidence to support treatment recommendations in medical toxicology textbooks...
  17. ncbi Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose
    George S Wang
    Section of Emergency Medicine, Children s Hospital, University of Colorado, Denver, Colorado, USA
    Pediatrics 127:e1077-80. 2011
    ..We suggest that elevated serum acetaminophen concentrations at the end of a standard 20-hour acetylcysteine infusion should be discussed with the local poison center...
  18. ncbi Olanzapine overdose mimicking opioid intoxication
    G F O'Malley
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Ann Emerg Med 34:279-81. 1999
    ..All 4 patients recovered with supportive care. Olanzapine should be added to opioid and alpha(2)-adrenergic agonist intoxication in the differential diagnosis of the patient with depressed mental status and miosis...