Research Topics
| M B RatcliffeSummaryCountry: USA Publications
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Publications
National Institutes of Health funding for cardiothoracic surgical researchMark B Ratcliffe
Department of Surgery, University of California, San Francisco, CA, USA
J Thorac Cardiovasc Surg 136:392-7; discussion 398-9. 2008..Our objective was determine the status of National Institutes of Health (NIH) funding for cardiothoracic surgery research...
Radio frequency heating of chronic ovine infarct leads to sustained infarct area and ventricular volume reductionM B Ratcliffe
Division of Cardiothoracic Surgery, Department of Surgery, San Francisco, USA
J Thorac Cardiovasc Surg 119:1194-204. 2000..We therefore tested the hypothesis that radio frequency heating of myocardial infarct tissue with application of a restraining patch causes a sustained reduction in myocardial infarct area and left ventricular volume...
Invited commentaryMark B Ratcliffe
Surgical Service (112, San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
Ann Thorac Surg 84:101-2. 2007
Ventricular volume, chamber stiffness, and function after anteroapical aneurysm plication in the sheepM B Ratcliffe
Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine of the University of California, San Francisco, USA
J Thorac Cardiovasc Surg 119:115-24. 2000....
Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model studyJ M Guccione
Department of Surgery, University of California, San Francisco, USA
Ann Thorac Surg 71:654-62. 2001..The mechanism of this regional dysfunction is poorly understood...
Effect of induction and reperfusion with warm substrate-enriched cardioplegia on ventricular functionA W Wallace
Department of Surgery, University of California, San Francisco Veterans Affairs Medical Center, USA
Ann Thorac Surg 70:1301-7. 2000..This study tested the hypothesis that induction and reperfusion with warm substrate-enriched (IRWSE) blood cardioplegia improves postoperative left ventricular (LV) function in patients undergoing elective coronary bypass surgery (CABG)...
L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgeryA W Wallace
Department of Anesthesiology, University of California, San Francisco, USA
Anesthesiology 90:1577-86. 1999..This experiment tested the hypothesis that intravenous systemic infusions of L-arginine, a precursor for nitric oxide production, dilate the coronary vascular bed of patients undergoing coronary artery bypass graft surgery...
Residual stress produced by ventricular volume reduction surgery has little effect on ventricular function and mechanics: a finite element model studyJ M Guccione
Department of Surgery, University of California, San Francisco, Calif, USA
J Thorac Cardiovasc Surg 122:592-9. 2001....
Collection of process data after cardiac surgery: initial implementation with a Java-based intranet appletM B Ratcliffe
Department of Surgery, School of Medicine of the University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 94121, USA
Ann Thorac Surg 69:1817-21; discussion 1821-2. 2000..Using a Java-based intranet program (applet), we collected postoperative process data after coronary artery bypass grafting...
Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failureOctavio A Victal
Social Securities Hospital, Guadalajara, Mexico
Circulation 105:1317-22. 2002..This technique may reduce the incidence of congestive heart failure and mortality in these patients and warrants investigation in larger clinical trials...
Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysmJoseph C Walker
Joint Graduate Group in Bioengineering, University of California, San Francisco, Calif, USA
J Thorac Cardiovasc Surg 135:1094-102, 1102.e1-2. 2008..Linear repair of left ventricular aneurysm has been performed with mixed clinical results. By using finite element analysis, this study evaluated the effect of this procedure on end-systolic stress...
Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheepPeng Zhang
Department of Surgery, University of California, San Francisco, Calif, USA
J Thorac Cardiovasc Surg 134:1017-24. 2007..We tested the hypotheses that the Dor procedure increases systolic circumferential shortening and longitudinal shortening in noninfarcted left ventricular regions in sheep...
Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imagingYi Jiang
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
Am J Physiol Heart Circ Physiol 293:H2377-84. 2007....
Theoretical impact of the injection of material into the myocardium: a finite element model simulationSamuel T Wall
University of California at Berkeley/San Francisco, Joint Graduate Group in Bioengineering, University of California at Berkeley, USA
Circulation 114:2627-35. 2006....
The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging studyJulius M Guccione
Department of Surgery, University of California, San Francisco, Calif, USA
J Thorac Cardiovasc Surg 131:579-586.e3. 2006..The primary goal of this study was to quantify the effect of anteroapical aneurysm plication on systolic deformation in noninfarcted adjacent (border zone) and remote left ventricular regions in sheep...
Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheepPeng Zhang
Department of Surgery, University of California, San Francisco, Calif, USA
J Thorac Cardiovasc Surg 130:1032-8. 2005..Unlike linear repair, left ventricular volume changes seem stable. The ejection fraction is improved, and left ventricular function (stroke volume and the Starling relationship) is maintained...
MRI-based finite-element analysis of left ventricular aneurysmJoseph C Walker
Joint Graduate Group in Bioengineering, University of California at Berkeley/San Francisco, CA, USA
Am J Physiol Heart Circ Physiol 289:H692-700. 2005..Stress calculations from these validated models show 24% increase in fiber stress and 115% increase in cross-fiber stress at the BZ relative to remote regions, which may contribute to LV remodeling...
Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheepJoseph C Walker
Joint Bioengineering Graduate Group, University of California Berkeley/San Francisco, USA
J Thorac Cardiovasc Surg 129:382-90. 2005..However, myofiber orientation is not abnormal after myocardial infarction, and thus surgical restoration techniques intent on restoring normal helix angles might not be warranted...
Myosplint decreases wall stress without depressing function in the failing heart: a finite element model studyJulius M Guccione
Department of Surgery, School of Medicine, University of California, and San Francisco Veterans Affairs Medical Center, CA 94121, USA
Ann Thorac Surg 76:1171-80; discussion 1180. 2003..We used a realistic mathematical (finite element) model of the dilated human LV to test the hypothesis that Myosplint decreased regional ventricular fiber stress and improved LV function...
Akinetic myocardial infarcts must contain contracting myocytes: finite-element model studyAlan B C Dang
Division of Cardiothoracic Surgery, School of Medicine, University of California-San Francisco, and SF Dept. of Veterans' Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
Am J Physiol Heart Circ Physiol 288:H1844-50. 2005..Without contracting myocytes, C = 250 kPa was necessary to achieve akinesis. If infarct stiffness is <285 times normal, contracting myocytes are required to prevent dyskinetic infarct wall motion...
Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model studyAlan B C Dang
School of Medicine of the University of California, San Francisco, San Francisco, California, USA
Ann Thorac Surg 79:185-93. 2005..CONCLUSIONS: These simulations support the use of SAVER in dilated hearts without a patch...
The treatment of ischemic heart failure with surgical ventricular restoration (SVR): new evidence of benefitMark B Ratcliffe
J Card Fail 12:195-8. 2006
Asymmetric mechanical properties of porcine aortic sinusesNamrata Gundiah
Department of Surgery, University of California at San Francisco Medical Center, San Francisco, California 94143, USA
Ann Thorac Surg 85:1631-8. 2008..The aim of this study is to compare the biaxial mechanical properties of the individual porcine aortic sinuses...
Ventricular remodeling surgery for heart failure: small animals and how to measure an improvement in ventricular functionJohn R Teerlink
Ann Thorac Surg 73:1368-70. 2002
The effect of preoperative diastolic dysfunction on outcome after surgical ventricular remodelingMark B Ratcliffe
J Thorac Cardiovasc Surg 134:280-3. 2007
