Research Topics
Species | Wei ZhengSummaryAffiliation: Purdue University Country: USA Publications
Research Grants
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Detail Information
Publications
Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseasesWei Zheng
School of Health Sciences, Purdue University, West Lafayette, Indiana, USA
Pharmacol Ther 133:177-88. 2012....- Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposureMamta Behl
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Cerebrospinal Fluid Res 6:11. 2009..Since metalloendopeptidase insulin-degrading enzyme (IDE), has been implicated in the metabolism of Abeta, we sought to investigate whether accumulation of Abeta following Pb exposure was due to the effect of Pb on IDE... - Biomarkers of manganese intoxicationWei Zheng
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Neurotoxicology 32:1-8. 2011..Considering the large accumulation of Mn in bone, developing an X-ray fluorescence spectroscopy or neutron-based spectroscopy method may create yet another novel non-invasive tool for assessing Mn exposure and toxicity... - Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley ratsWei Zheng
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Neurotoxicology 30:240-8. 2009..These data suggest that PAS likely acts as a chelating agent to mobilize and remove tissue Mn. A high-dose and prolonged PAS treatment appears necessary for its therapeutic effectiveness... - Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1Mamta Behl
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1169, West Lafayette, IN 47907, USA
Toxicol Appl Pharmacol 240:245-54. 2009.... - Use of Z310 cells as an in vitro blood-cerebrospinal fluid barrier model: tight junction proteins and transport propertiesLewis Zhichang Shi
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907 2051, United States
Toxicol In Vitro 22:190-9. 2008..Taken together, these data indicate that the Z310 BCB model expresses major tight junction proteins and forms a tight barrier in vitro. The model also exhibits the ability to transport substances of various categories across the barrier... - Manganese exposure among smelting workers: relationship between blood manganese-iron ratio and early onset neurobehavioral alterationsDallas M Cowan
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
Neurotoxicology 30:1214-22. 2009..Combining their usefulness in Mn-exposure assessment, we recommend that the blood Mn-Fe ratio may serve as a reasonable biomarker not only for assessment of Mn exposure but also for health risk assessment... - Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposureXueqian Wang
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Exp Biol Med (Maywood) 233:1561-71. 2008..Enhanced TfR-mediated influx of Fe from the blood and ferroportin-mediated expelling Fe toward the CSF may compromise DMT1-mediated efflux, leading to an increased Fe concentration in the CSF as seen in Mn-exposed animals... - Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or ironXueqian Wang
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Toxicol Appl Pharmacol 230:167-74. 2008..The intracellular trafficking of metal transporters in the choroid plexus following Mn exposure may partially contribute to Mn-induced disruption in Fe homeostasis in the cerebrospinal fluid (CSF) following Mn exposure... - Macromolecules involved in production and metabolism of beta-amyloid at the brain barriersJanelle S Crossgrove
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
Brain Res 1138:187-95. 2007..Disruption of this homeostasis due to aging, injury or toxicant exposure may contribute to accumulation of beta-amyloid peptides in the brain fluids, leading to AD... - Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase CMamta Behl
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Neurotoxicology 31:524-32. 2010..These studies suggest that Pb exposure disrupts Abeta homeostasis at the CP, owing partly to a Pb-induced relocalization of LRP1 via PKC-delta... - Regulation of brain copper homeostasis by the brain barrier systems: effects of Fe-overload and Fe-deficiencyAndrew D Monnot
School of Health Sciences, Purdue University, West Lafayette, IN, USA
Toxicol Appl Pharmacol 256:249-57. 2011..FeD has a more profound effect on brain Cu levels than FeO. FeD increases Cu transport at the brain barriers and prompts Cu overload in the CNS. The BCB plays a key role in removing the excess Cu from the CSF... - Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier, in vitroLewis Zhichang Shi
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907, USA
Hum Exp Toxicol 26:159-67. 2007..The immature barrier appears to be more vulnerable to Pb toxicity than the mature, well-developed, brain barrier, the fact possibly contributing to Pb-induced neurotoxicity among young children... - The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the ratScott E Kanoski
Department of Psychological Sciences, Purdue University, West Lafayette, IN 19104 6241, USA
J Alzheimers Dis 21:207-19. 2010..These results indicate that hippocampal function may be particularly vulnerable to disruption by HE-diets, and this disruption may be related to impaired BBB integrity... - Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitroXueqian Wang
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907, USA
Brain Res 1097:1-10. 2006..The facilitated transport of Fe by DMT1 at the blood-CSF barrier may partly contribute to Mn-induced neurodegenerative Parkinsonism... - Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposureG Jane Li
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL 1163D, West Lafayette, IN 47907, USA
Neurotoxicology 27:737-44. 2006..The disrupted Fe transport by brain barriers may underlie the distorted Fe homeostasis in the CSF... - In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganeseUlrike Dydak
School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Environ Health Perspect 119:219-24. 2011..Exposure to excessive levels of manganese (Mn) is known to induce psychiatric and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means for early detection of Mn neurotoxicity is desirable... - 1?, 25-Dihydroxyvitamin D regulates hypoxia-inducible factor-1? in untransformed and Harvey-ras transfected breast epithelial cellsYan Jiang
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47906, USA
Cancer Lett 298:159-66. 2010..These results support that 1,25(OH)(2)D regulates HIF-1? protein level via transcriptional regulation in MCF10A cells in contrast to through proteosomal degradation with the presence of H-ras oncogene in MCF10A cells... - Manganese exposure among smelting workers: blood manganese-iron ratio as a novel tool for manganese exposure assessmentDallas M Cowan
School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Biomarkers 14:3-16. 2009..77, p < 0.01) and plasma (pMIR) (r = 0.70, p < 0.01). The results suggest that the MIR may serve as a useful biomarker to distinguish Mn-exposed workers from the unexposed, control population... - Copper transport to the brain by the blood-brain barrier and blood-CSF barrierByung Sun Choi
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907 2051, USA
Brain Res 1248:14-21. 2009.... - Brain barrier systems: a new frontier in metal neurotoxicological researchWei Zheng
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Toxicol Appl Pharmacol 192:1-11. 2003..They represent both clear challenges and fruitful research domains not only in neurotoxicology, but also in neurophysiology and pharmacology... - Visualizing systemic clearance and cellular level biodistribution of gold nanorods by intrinsic two-photon luminescenceLing Tong
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
Langmuir 25:12454-9. 2009..With spectral detection to distinguish GNR TPL from tissue autofluorescence, we also mapped the cellular distribution of GNRs in the explanted organs, and found most GNRs resided in the macrophages in liver and spleen... - Brain regional pharmacokinetics of p-aminosalicylic acid and its N-acetylated metabolite: effectiveness in chelating brain manganeseLan Hong
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Drug Metab Dispos 39:1904-9. 2011..Furthermore, PAS and AcPAS seem to be effective in reducing manganese levels in brain... - The choroid plexus removes beta-amyloid from brain cerebrospinal fluidJanelle S Crossgrove
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, CIVL-1163D, West Lafayette, IN 47907, USA
Exp Biol Med (Maywood) 230:771-6. 2005..Overall, these results suggest the choroid plexus selectively cleanses Abeta from the CSF by an undetermined mechanism(s), potentially reducing Abeta from normal brains and the brains of Alzheimer's disease patients... - Manganese toxicity upon overexposureJanelle Crossgrove
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
NMR Biomed 17:544-53. 2004..In conclusion, repeated administration of Mn, or compounds that readily release Mn, may increase the risk of Mn-induced toxicity... - Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitroG Jane Li
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907, USA
Toxicol Appl Pharmacol 205:188-200. 2005..The disrupted protein-TfR mRNA interaction in the choroidal epithelial cells may explain the toxicity of manganese at the blood-CSF barrier... - Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological studyLewis Zhichang Shi
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Room 1163D, West Lafayette, IN 47907-2051, USA
Brain Res 1057:37-48. 2005..The Z310 cell-based in vitro model appears to be suitable for transepithelial transport study of drugs and toxicants... - Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat developmentQiang Wang
Department of Occupational and Environmental Health, Faculty of Military Preventive Medicine, Fourth Military Medical University, 17 Changlexi Street, Xi an, 710032, China
Toxicol Appl Pharmacol 219:33-41. 2007..The increased BBB permeability may facilitate the accumulation of Pb. Fe supplement appears to protect the integrity of the BBB against Pb insults, a beneficial effect that may have significant clinical implications... - The blood-CSF barrier in culture. Development of a primary culture and transepithelial transport model from choroidal epithelial cellsWei Zheng
Division of Environmental Health Sciences, School of Public Health, Columbia University, New York, NY, USA
Methods Mol Biol 188:99-114. 2002
Research Grants
- Choroid Plexus as a Target in Metal-Induced NeurotoxicityWei Zheng; Fiscal Year: 2009....
- Choroid Plexus as a Target in Metal-Induced NeurotoxicityWei Zheng; Fiscal Year: 2007....
- Creation of an In Vitro Brain Barrier Transport SystemWei Zheng; Fiscal Year: 2006....
- Choroid Plexus a Target in Metal-Induced NeurotoxicityWei Zheng; Fiscal Year: 2005..In addition, we will study the effect of Mn on the RNA binding capability of a newly discovered IRP which regulates the synthesis of an [Fe-S] subunit of Complex-I. ..
- Workshop on Choroid Plexus in Brain Health and Disease.Wei Zheng; Fiscal Year: 2003..abstract_text> ..
- CHOROID PLEXUS AS A TARGET IN LEAD INDUCED NEUROTOXICITYWei Zheng; Fiscal Year: 2000..We believe that this study will likely create a highly fruitful avenue of research in environmental neurotoxicology. ..
- Choroid Plexus as a Target in Metal-Induced NeurotoxicityWei Zheng; Fiscal Year: 2010..This project will uncover how Cu is transferred in and out of the brain and how exposure to environmental toxicant manganese (Mn) interferes with the Cu balance in brain, which in turn causes the degenerative manganese parkinsonism. ..