Research Topics
| Jing WuSummaryAffiliation: Purdue University Country: USA Publications
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Detail Information
Publications
Improving the specificity of exon prediction using comparative genomicsJing Wu
Department of Statistics, Purdue University, 150 N, University Street, West Lafayette, IN 47906, USA
BMC Genomics 9:S13. 2008..Computational gene prediction tools routinely generate large volumes of predicted coding exons (putative exons). One common limitation of these tools is the relatively low specificity due to the large amount of non-coding regions...
Coding exon detection using comparative sequencesJing Wu
Department of Statistics, Purdue University, West Lafayette, Indiana 47906, USA
J Comput Biol 13:1148-64. 2006..Last, shortHMM is also capable of finding new potential exons...
Hidden Markov model and its applications in motif findingsJing Wu
Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA
Methods Mol Biol 620:405-16. 2010..We then introduce the application of HMM to a complex system in which an HMM is combined with Bayesian inference to identify transcription factor binding sites and cis-regulatory modules...
Statistical methods in integrative analysis for gene regulatory modulesLingmin Zeng
Purdue University
Stat Appl Genet Mol Biol 7:Article 28. 2008..The multiple data sources provide information of transcriptional regulation from different aspects. Therefore, the integrative analysis offers a fine prediction on transcriptional regulatory code and infers potential regulatory networks...
Screen and clean: a tool for identifying interactions in genome-wide association studiesJing Wu
Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
Genet Epidemiol 34:275-85. 2010..When the method is applied to data obtained from the Wellcome Trust Case Control Consortium study of Type 1 Diabetes it uncovers evidence supporting interaction within the HLA class II region as well as within Chromosome 12q24...
Computation-based discovery of cis-regulatory modules by hidden Markov modelJing Wu
Department of Statistics, Purdue University, West Lafayette, Indiana 47907, USA
J Comput Biol 15:279-90. 2008..The executable codes of our programs and module predictions across the fly Drosophila genome are available at www.stat.purdue.edu/~ jingwu/module/...
A small trypsin inhibitor from the frog of Odorrana grahamiJianxu Li
Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences CAS, Kunming 650223, Yunnan, China
Biochimie 90:1356-61. 2008..In addition to its unique six-residue loop, the overall structure and precursor of OGTI are different from those of other serine protease inhibitors. It is also one of the smallest serine protease inhibitors ever found...
dPattern: transcription factor binding site (TFBS) discovery in human genome using a discriminative pattern analysisSeung Hee Bae
Department of Computer Science, Indiana University Bloomington, IN 47404, USA
Bioinformatics 23:2619-21. 2007..RESULTS: By modifying our previous REFINEMENT approach, we developed dPattern that searches for occurrences of TFBSs in the promotor regions of up/down regulated or random genes...
Anti-infection peptidomics of amphibian skinJianxu Li
Biotoxin Units and gLaboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
Mol Cell Proteomics 6:882-94. 2007..With respect to the development of antibiotics, these peptides provide potential new templates to explore further...
Cryopreservation of human embryonic stem cells: a protocol by programmed coolingPeng-Fei Yang
Institute of Cryomedicine and Food Refrigeration, Shanghai University of Science and Technology, and Laboratory of Tissue Engineer, The 9th People's Hospital, Shanghai, China
Cryo Letters 27:361-8. 2006..They retained the properties of pluripotent cells, had a normal karyotype and showed histochemical staining for alkaline phosphatase...
Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activationJing Wu
Department of Pharmacology, University of Wisconsin School of Medicine, Madison, WI 53706, USA
Mol Cell Biol 27:2411-22. 2007..These results establish the molecular basis for a novel AP-1/GR-Notch4 axis in vascular endothelium...
A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNAWencheng Li
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China
FEMS Microbiol Lett 266:20-8. 2007..Possible reasons for this, and the role and evolution of the observed distribution of TTA codons among Streptomyces genes were discussed...
Molecular determinants of NOTCH4 transcription in vascular endotheliumJing Wu
Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 1300 University Ave, 383 Medical Sciences Center, Madison, WI 53706, USA
Mol Cell Biol 25:1458-74. 2005..These results reveal an AP-1-Notch4 pathway, which we propose to be crucial for transducing angiogenic signals and to be deregulated upon aberrant signal transduction in cancer...
Functional and biochemical characterization of a recombinant Arabidopsis thaliana 3-deoxy-D-manno-octulosonate 8-phosphate synthaseJing Wu
Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109-1065, USA
Biochem J 381:185-93. 2004..8 microM for D-arabinose 5-phosphate and kcat=5.9 s(-1) at 37 degrees C. On the basis of the characterization of A. thaliana KDOPS and phylogenetic analysis, plant KDOPSs may represent a new, distinct class of KDOPSs...
[PIV: a computer-aided portal image verification system]Weihua Fu
Department of Radiotherapy Oncology, Cancer Institute (Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 19:664-6. 2002..Semi-automatic register methods make verification more accurate than view-box method. It can provide useful quantitative errors for regular fields. PIV is flexible and accurate. It is an effective tool for portal field verification...
[Cloning and expression of human calcyclin binding protein (hCacyBP) gene]Wei Xia Liu
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 10005, China
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:181-6. 2002..The results of immunohistochemistrial staining showed that the location of CacyBP in BT325 cell line before and after differentiation changed from cytoplasm into nucleus and perinucleus cytoplasm...
