Research Topics
| P G LeimanSummaryAffiliation: Purdue University Country: USA Publications
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Detail Information
Publications
Structure of the cell-puncturing device of bacteriophage T4Shuji Kanamaru
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-1392, USA
Nature 415:553-7. 2002..The amino-terminal, antiparallel beta-barrel domain of gp5 is inserted into a cylinder formed by three gp27 monomers, which may serve as a channel for DNA ejection...- Evolution of a new enzyme activity from the same motif foldPetr G Leiman
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907, USA
Mol Microbiol 69:287-90. 2008..The substrate-binding site is intrasubunit in P22 and HK620 tailspikes, but intersubunit in Sf6, demonstrating how phages can adapt the same protein fold to recognize different substrates... - The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificitiesPetr G Leiman
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Mol Biol 371:836-49. 2007..The enzymes recognize the adapter protein by a conserved N-terminal sequence, providing a mechanism for phages to acquire different enzymes and thus to evolve new host specificities... - Structure and morphogenesis of bacteriophage T4P G Leiman
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, Indiana 47907 2054, USA
Cell Mol Life Sci 60:2356-70. 2003..Similar to other phages, and also herpes viruses, the unique vertex is occupied by a dodecameric portal protein, which is involved in DNA packaging... - Three-dimensional rearrangement of proteins in the tail of bacteriophage T4 on infection of its hostPetr G Leiman
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
Cell 118:419-29. 2004..A comparison with the metastable hexagonal baseplate of the mature virus shows that the baseplate proteins move as rigid bodies relative to each other during the structural change... - Structure of bacteriophage T4 gene product 11, the interface between the baseplate and short tail fibersP G Leiman
Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907 1392, USA
J Mol Biol 301:975-85. 2000.... - The structure of gene product 6 of bacteriophage T4, the hinge-pin of the baseplateAnastasia A Aksyuk
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
Structure 17:800-8. 2009..However, the hinge angle between the N- and C-terminal parts of gp6 changes by approximately 15 degrees , accounting for a 10 A radial increase in the diameter of the gp6 ring... - Structure and location of gene product 8 in the bacteriophage T4 baseplatePetr G Leiman
Department of Biological Sciences, Purdue University, Lilly Hall of Life Sciences, West Lafayette, IN 47907 2054, USA
J Mol Biol 328:821-33. 2003..With the structure determination of gp8, a total of 53% of the volume of the baseplate has now been interpreted in terms of its atomic structure... - Evolution of bacteriophage tails: Structure of T4 gene product 10Petr G Leiman
Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
J Mol Biol 358:912-21. 2006..Such events are usual in the evolution of complex organelles from a common primordial molecule... - From structure of the complex to understanding of the biologyMichael G Rossmann
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
Acta Crystallogr D Biol Crystallogr 63:9-16. 2007.... - The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteriaAnastasia A Aksyuk
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
EMBO J 28:821-9. 2009..It was shown that during contraction, gp18 subunits slide over each other with no apparent change in their structure... - Combining X-ray crystallography and electron microscopyMichael G Rossmann
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 2054, USA
Structure 13:355-62. 2005..Factors affecting the quality of cryo-electron microscopy maps and limits of accuracy in fitting known structural fragments are discussed... - The bacteriophage T4 DNA injection machineMichael G Rossmann
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
Curr Opin Struct Biol 14:171-80. 2004..In the center of the dome, there is a membrane-puncturing device, containing three lysozyme domains, which disrupts the intermembrane peptidoglycan layer during infection... - Structure determination of the head-tail connector of bacteriophage phi29A A Simpson
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392, USA
Acta Crystallogr D Biol Crystallogr 57:1260-9. 2001..This domain probably acts as a bearing, allowing the connector to rotate within the pentagonal portal of the prohead during DNA packaging... - Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary originPetr G Leiman
Department of Biological Sciences, Purdue University, West Lafayette, IN 47906, USA
Proc Natl Acad Sci U S A 106:4154-9. 2009..We propose that T6SS is a multicomponent structure whose extracellular part resembles both structurally and functionally a bacteriophage tail, an efficient machine that translocates proteins and DNA across lipid membranes into cells... - The tail structure of bacteriophage T4 and its mechanism of contractionVictor A Kostyuchenko
Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, Indiana 47907-2054, USA
Nat Struct Mol Biol 12:810-3. 2005..During contraction, the tail tube extends beneath the baseplate by about one-half of its total length and rotates by 345 degrees , allowing it to cross the host's periplasmic space... - Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spikeYe Xiang
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
Mol Cell 34:375-86. 2009..Structural and sequence comparisons suggest that some eukaryotic and bacterial viruses as well as bacterial adhesins might have a similar maturation mechanism as is performed by phi29 gp12 for Bacillus subtilis... - Molecular architecture of the prolate head of bacteriophage T4Andrei Fokine
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054, USA
Proc Natl Acad Sci U S A 101:6003-8. 2004..The binding sites and shape of the hoc and soc proteins have been established by analysis of the soc(-) and hoc(-)soc(-) T4 structures... - Structural and functional similarities between the capsid proteins of bacteriophages T4 and HK97 point to a common ancestryAndrei Fokine
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
Proc Natl Acad Sci U S A 102:7163-8. 2005..Structural data show that capsid proteins of most tailed phages, and some eukaryotic viruses, may have evolved from a common ancestor... - Three-dimensional structure of bacteriophage T4 baseplateVictor A Kostyuchenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, 16/10 Miklukho-Maklaya Str, 117997 Moscow, Russia
Nat Struct Biol 10:688-93. 2003..The baseplate structure suggests a mechanism of baseplate triggering and structural transition during the initial stages of T4 infection...