Research Topics
| Barry L JacobsSummaryAffiliation: Princeton University Country: USA Publications
Research Grants
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Detail Information
Publications
Adult brain neurogenesis and psychiatry: a novel theory of depressionB L Jacobs
Program in Neuroscience, Princeton University, Princeton, NJ 08544 1010, USA
Mol Psychiatry 5:262-9. 2000..Thus, we hypothesize that the waning and waxing of neurogenesis in the hippocampal formation are important causal factors, respectively, in the precipitation of, and recovery from, episodes of clinical depression...- Adult brain neurogenesis and depressionBarry L Jacobs
Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
Brain Behav Immun 16:602-9. 2002..The possible interaction of immune system factors, especially the proinflammatory cytokines, with adult brain neurogenesis is discussed... - Activity of medullary serotonergic neurons in freely moving animalsBarry L Jacobs
Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
Brain Res Brain Res Rev 40:45-52. 2002..We hypothesize that the primary functions of this motor-related activity are to facilitate motor output, suppress processing of some forms of afferent activity, and to coordinate autonomic functioning with the current motor demand... - "Fatigue" of medullary but not mesencephalic raphe serotonergic neurons during locomotion in catsCasimir A Fornal
Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
Brain Res 1072:55-61. 2006..Full recovery of single unit activity to a level approximating the baseline discharge rate required 30-45 min. Possible mechanisms underlying these changes are discussed as is the role of serotonin and fatigue in human pathology... - Circadian variation in mouse hippocampal cell proliferationLinda J Kochman
Program in Neuroscience, Princeton University, Princeton, NJ 08540 1010, USA
Neurosci Lett 406:256-9. 2006..Since it is generally believed that proliferating cells in the hilus and GCL/SGZ give rise primarily to glia and neurons, respectively, these data suggest a possible circadian influence on gliogenesis, rather than neurogenesis... - Effects of the hypnotic drug zolpidem on cell proliferation and survival in the dentate gyrus of young and old ratsLuiz F Takase
Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
Brain Res 1259:26-31. 2009..To the extent that zolpidem improves sleep, these data suggest little or no benefit of hypnotic drug treatment on neurogenesis parameters in young or old rats... - Suppression of hippocampal cell proliferation by short-term stimulant drug administration in adult ratsLinda J Kochman
Program in Neuroscience, Princeton University, Princeton, NJ 08544, USA
Eur J Neurosci 29:2157-65. 2009.... - Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanismJason J Radley
Program in Neuroscience, Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Brain Res 966:1-12. 2003.... - Delayed suppression of hippocampal cell proliferation in rats following inescapable shocksCasimir A Fornal
Program in Neuroscience, Princeton University, Princeton, NJ 08544, USA
Brain Res 1130:48-53. 2007..These data raise questions about the general nature of the relationship between CORT and CP. They also suggest that, under some conditions, changes in hippocampal CP may emerge only after an "incubation period"... - Insulin-induced hypoglycemia decreases single-unit activity of serotonergic medullary raphe neurons in freely moving cats: relationship to sympathetic and motor outputFrancisco J Martin-Cora
Program in Neuroscience, Princeton University, Princeton, New Jersey 08544, USA
Eur J Neurosci 16:722-34. 2002.... - Despite strong behavioral disruption, Delta9-tetrahydrocannabinol does not affect cell proliferation in the adult mouse dentate gyrusLinda J Kochman
Program in Neuroscience, Department of Psychology, Princeton University, Green Hall, Washington Road, Princeton, NJ 08540 1010, USA
Brain Res 1113:86-93. 2006..These findings provide no evidence for an effect of THC on hippocampal cell proliferation, even at doses producing gross behavioral intoxication. Whether marijuana or THC affects neurogenesis remains to be explored... - 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrusJason J Radley
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Brain Res 955:264-7. 2002..This suggests that 5-HT(1A) receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation... - Repeated brief social defeat episodes in mice: effects on cell proliferation in the dentate gyrusJasmine J Yap
Department of Psychology, Tufts University, 530 Boston Avenue, Bacon Hall, Medford, MA 02155, USA
Behav Brain Res 172:344-50. 2006.... - Single-unit responses of serotonergic medullary raphe neurons to cardiovascular challenges in freely moving catsFrancisco J Martin-Cora
Department of Physiology, School of Medicine, USC, Santiago de Compostela, Galicia 15782, Spain
Eur J Neurosci 22:3195-204. 2005..Taken within the context of our previous work, the present data suggest that medullary serotonergic neurons may modulate autonomic outflow, but only in relation to their primary role in motor control... - Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the ratLuiz F Takase
Departmento de Anatomia, , , Brasil
Behav Brain Res 162:299-306. 2005..The relevance of these results for elucidating the neural bases of psychopathology is discussed... - The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult ratAvery Tung
Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
Anesth Analg 106:1772-7. 2008..To test this hypothesis, we investigated the effects of prolonged anesthesia with four different anesthetics on hippocampal cell proliferation in young and older rats... - Age-dependent decline in hippocampal neurogenesis is not altered by chronic treatment with fluoxetineDaniel S Cowen
Department of Psychiatry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
Brain Res 1228:14-9. 2008..In addition to finding no age-dependent effects, our data question the general reproducibility of previously reported fluoxetine effects in animals... - Inescapable shock activates serotonergic neurons in all raphe nuclei of ratLuiz F Takase
Departmento de Anatomia, , Universidade de Sao Paulo, Sao Paulo SP, Brazil
Behav Brain Res 153:233-9. 2004..This stimulus exerted a consistent and strong activation of the entire midline brain stem system of serotonergic neurons. The implications of these findings for animal models of human psychopathology are discussed...
Research Grants
- Marijuana & Cytokine Actions on Rat Brain MitogenesisBarry Jacobs; Fiscal Year: 2004..It is further hypothesized that the actions of the two compounds will be at least additive in suppressing DG mitogenesis. ..
- NEURAL SUBSTRATES OF AROUSAL AND EMOTIONBarry Jacobs; Fiscal Year: 1990..I.M.H. because of the involvement of brain NE and 5HT neurons in arousal and emotionality, and more generally, because of the role of stress in the etiology of various forms of psychopathology...
- NEURAL SUBSTRATES OF AROUSAL AND EMOTIONBarry Jacobs; Fiscal Year: 1991....
- NEURAL SUBSTRATES OF AROUSAL AND EMOTIONBarry Jacobs; Fiscal Year: 1980..The present research program seeks to clarify the functional role of CNS serotonin through animal experiments which analyze the basic component of the system, serotonin-containing neurons of the raphe nuclei, in freely moving cats. ..
- NEURAL SUBSTRATES OF AROUSAL AND EMOTIONBarry Jacobs; Fiscal Year: 2005....