A Bendelac

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. ncbi Autoreactivity by design: innate B and T lymphocytes
    A Bendelac
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nat Rev Immunol 1:177-86. 2001
  2. ncbi Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity
    Albert Bendelac
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    J Exp Med 195:F19-23. 2002
  3. ncbi CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain
    J Jayawardena-Wolf
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Immunity 15:897-908. 2001
  4. ncbi The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families
    S H Park
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Exp Med 193:893-904. 2001
  5. ncbi CD1 and lipid antigens: intracellular pathways for antigen presentation
    J Jayawardena-Wolf
    Department of Molecular Biology, Schultz Laboratory, Room 416, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Curr Opin Immunol 13:109-13. 2001
  6. ncbi Mouse CD1-specific NK1 T cells: development, specificity, and function
    A Bendelac
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Annu Rev Immunol 15:535-62. 1997
  7. ncbi CD1-restricted T-cell responses and microbial infection
    S H Park
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nature 406:788-92. 2000
  8. ncbi Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
    C Carnaud
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    J Immunol 163:4647-50. 1999
  9. ncbi Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties
    Yang Liu
    Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT 84602, USA
    Bioorg Med Chem Lett 18:3052-5. 2008
  10. ncbi Distinct functional lineages of human V(alpha)24 natural killer T cells
    Peter T Lee
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Exp Med 195:637-41. 2002

Collaborators

  • S H Park
  • R Mehr
  • C Carnaud
  • K Hoebe
  • David H Raulet
  • BRUCE A BEUTLER
  • MITCHELL E KRONENBERG
  • Luc Teyton
  • Paul B Savage
  • Jochen Mattner
  • Carlos Cantu
  • Dapeng Zhou
  • Randal D Goff
  • Yang Liu
  • Kamel Benlagha
  • Claire Forestier
  • Datsen G Wei
  • Christine Borowski
  • J Jayawardena-Wolf
  • Ying Gao
  • Ning Yin
  • Klaus Griewank
  • Dirk M Zajonc
  • Jean Francois Bach
  • Peter T Lee
  • Xiao-ti Zhou
  • Sofia A Oliveira
  • Ya Hui Chiu
  • Shenglou Deng
  • Li Bai
  • Stefan Freigang
  • Svend Rietdijk
  • Alusha A Mamchak
  • Cox Terhorst
  • Ninghai Wang
  • Aimee Julien
  • Barbara A Sullivan
  • Chris C Ibegbu
  • Archana Khurana
  • Eugene V Ravkov
  • John D Altman
  • Ian A Wilson
  • Nahed Ismail
  • Hyunji Lee
  • Lucie Beaudoin
  • Pierre Saint-Mezard
  • Agnes Lehuen
  • Kristin L Debord
  • Olaf Schneewind
  • Vivien Wang
  • David Walker
  • Nicolas Schrantz
  • Gennaro De Libero
  • Harvey Cantor
  • Richard L Proia
  • Steven B Levery
  • Michael B Brenner
  • Matthias G Von Herrath
  • Yuval Sagiv
  • Susann Teneberg
  • Yun-Ping Wu
  • Dacheng Wang
  • Tadashi Yamashita
  • Lewis L Lanier
  • Kelly Hudspeth
  • Yun Ping Wu
  • Mark J Shlomchik
  • Datsen Wei
  • Chunhong Li
  • Jayanthi Jayawardena-Wolf
  • Thomas E Shenk
  • Ya-Hui Chiu
  • Peter Lee
  • Y H Chiu
  • K Benlagha

Detail Information

Publications26

  1. ncbi Autoreactivity by design: innate B and T lymphocytes
    A Bendelac
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nat Rev Immunol 1:177-86. 2001
    ..New studies have shed light on the principles and mechanisms that drive their unique development and function, and show their resemblance to another subset of innate lymphocytes, the natural killer cells...
  2. ncbi Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity
    Albert Bendelac
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    J Exp Med 195:F19-23. 2002
  3. ncbi CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain
    J Jayawardena-Wolf
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Immunity 15:897-908. 2001
    ..These results reveal the complexity of CD1d trafficking and suggest that the invariant chain was a component of ancestral antigen presentation pathways prior to the evolution of MHC and CD1...
  4. ncbi The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families
    S H Park
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Exp Med 193:893-904. 2001
    ..Altogether, these findings imply that lipid recognition by CD1d-restricted T cells may have largely evolved as an innate rather than an adaptive arm of the mouse immune system...
  5. ncbi CD1 and lipid antigens: intracellular pathways for antigen presentation
    J Jayawardena-Wolf
    Department of Molecular Biology, Schultz Laboratory, Room 416, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Curr Opin Immunol 13:109-13. 2001
    ..Emerging models suggest that CD1 may have evolved to monitor the integrity of membrane lipids and/or to present microbial lipid antigens to both alpha beta and gamma delta T cells...
  6. ncbi Mouse CD1-specific NK1 T cells: development, specificity, and function
    A Bendelac
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Annu Rev Immunol 15:535-62. 1997
    ..Here, we review the specificity and function of mouse NK1 T cells, and we discuss the relationship of this lineage to mainstream T cells and NK cells...
  7. ncbi CD1-restricted T-cell responses and microbial infection
    S H Park
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nature 406:788-92. 2000
    ..The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants...
  8. ncbi Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
    C Carnaud
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    J Immunol 163:4647-50. 1999
    ..They also suggest that the antitumor effects of alpha-GalCer result from the sequential recruitment of distinct innate and adaptive effector lymphocytes...
  9. ncbi Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties
    Yang Liu
    Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT 84602, USA
    Bioorg Med Chem Lett 18:3052-5. 2008
    ..We found that substitution did not significantly impact glycosidase activity or loading into CD1d...
  10. ncbi Distinct functional lineages of human V(alpha)24 natural killer T cells
    Peter T Lee
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Exp Med 195:637-41. 2002
    ..These findings may explain how NKT cells could promote Th2 responses in some conditions and Th1 in others, and should be taken into consideration for intervention in relevant diseases...
  11. ncbi Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development
    Klaus Griewank
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Immunity 27:751-62. 2007
    ..Thus, the topography of NKT cell ligand recognition determines the availability of a cosignaling pathway that is essential for NKT cell lineage development...
  12. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
    ....
  13. ncbi Glycolipids for natural killer T cells
    Paul B Savage
    Department of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA
    Chem Soc Rev 35:771-9. 2006
    ..These advances have included determination of the lipid and carbohydrate recognition requirements for stimulation and identification of "natural" antigens for these cells...
  14. ncbi A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells
    Yang Liu
    Brigham Young University, Provo, UT 84602, USA
    J Immunol Methods 312:34-9. 2006
    ..We have developed an alpha-galactosyl ceramide with improved solubility over KRN7000 that effectively stains NKT cells, both mouse and human, and stimulates cytokine release at low concentrations...
  15. ncbi Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes
    Datsen G Wei
    Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 202:239-48. 2005
    ..These surprising findings suggest that, unlike thymic epithelial cells, cortical thymocytes can provide unexpected, cell type-specific signals leading to lineage expansion and NKT cell differentiation...
  16. ncbi Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
    Dirk M Zajonc
    Department of Molecular Biology and The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 6:810-8. 2005
    ....
  17. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005
    ..These findings identify two novel antigenic targets of NKT cells in antimicrobial defence, and show that glycosylceramides are an alternative to LPS for innate recognition of the Gram-negative, LPS-negative bacterial cell wall...
  18. ncbi Signaling for NKT cell development: the SAP-FynT connection
    Christine Borowski
    University of Chicago, Chicago, IL 60637, USA
    J Exp Med 201:833-6. 2005
    ..In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells...
  19. ncbi The role of innate immunity in autoimmunity
    Jean Francois Bach
    INSERM U580, Hopital Necker, Paris, France
    J Exp Med 200:1527-31. 2004
    ....
  20. ncbi Lysosomal glycosphingolipid recognition by NKT cells
    Dapeng Zhou
    University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Science 306:1786-9. 2004
    ..We suggest that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity...
  21. ncbi Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells
    Randal D Goff
    Brigham Young University, Provo, Utah 84602, USA
    J Am Chem Soc 126:13602-3. 2004
    ..In similar fashion, the length of the acyl chain in alpha-galactosylceramides influences cytokine release profiles...
  22. ncbi Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d
    Ya Hui Chiu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Nat Immunol 3:55-60. 2002
    ....
  23. ncbi The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs
    Carlos Cantu
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 170:4673-82. 2003
    ..This suggests that there is less accommodation made by this TCR in recognizing alpha-galactosylceramide, and it can be assumed that the most rigid part of the Ag, the sugar moiety, is critical in the interaction...
  24. ncbi Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides
    Xiao-ti Zhou
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    Org Lett 4:1267-70. 2002
    ..The appended molecules do not significantly influence the abilities of the glycolipids to stimulate T cells. [reaction: see text]..
  25. ncbi Murine cytomegalovirus m02 gene family protects against natural killer cell-mediated immune surveillance
    Sofia A Oliveira
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA
    J Virol 76:885-94. 2002
    ..These results argue that one or more members of the m02 gene family antagonize natural killer cell-mediated immune surveillance...
  26. ncbi T cell development in mice expressing CD1d directed by a classical MHC class II promoter
    Claire Forestier
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Immunol 171:4096-104. 2003
    ....