Research Topics
| Dexiang ChenSummaryAffiliation: PowderJect Vaccines Country: USA Publications
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Detail Information
Publications
Adjuvantation of epidermal powder immunizationD Chen
PowderJect Vaccines Inc, 585 Science Drive, Madison, WI 53711, USA
Vaccine 19:2908-17. 2001..EPI is a promising immunization method that may be used to administer a broad range of vaccines including vaccines with adjuvants...- Serum and mucosal immune responses to an inactivated influenza virus vaccine induced by epidermal powder immunizationD Chen
PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
J Virol 75:7956-65. 2001..The ability to elicit augmented circulating antibody and mucosal antibody responses makes EPI a promising alternative to needle injection for administering vaccines against influenza and other diseases... - Epidermal powder immunization induces both cytotoxic T-lymphocyte and antibody responses to protein antigens of influenza and hepatitis B virusesD Chen
PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
J Virol 75:11630-40. 2001..In summary, EPI directly delivers protein antigens to the cytosol of the LCs in the skin and elicits both cellular and antibody responses... - Epidermal powder immunization: cellular and molecular mechanisms for enhancing vaccine immunogenicityDexiang Chen
PowderJect Vaccines Inc, 585 Science Drive, Madison, WI 53711, USA
Virus Res 103:147-53. 2004..These results have important implications for the development of a more efficacious human influenza vaccine... - Targeting epidermal Langerhans cells by epidermal powder immunizationDexiang Chen
PowderJect Vaccines, Inc, Madison, WI 53711, USA
Cell Res 12:97-104. 2002..Epidermal powder immunization (EPI) is a technology that offers a tool to manipulate the LCs and the potential to harness the immune reactions towards prevention and treatment of infectious diseases and immune disorders... - Epidermal powder immunization with a recombinant HIV gp120 targets Langerhans cells and induces enhanced immune responsesDexiang Chen
PowderJect Vaccines, Inc, 585 Science Drive, Madison, WI 53711, USA
AIDS Res Hum Retroviruses 18:715-22. 2002..EPI may serve as a useful tool to evaluate vaccine potential of the rgp120 protein... - Needle-free epidermal powder immunizationDexiang Chen
PowderJect Vaccines Inc, Madison, WI 53711, USA
Expert Rev Vaccines 1:265-76. 2002..Emphasis will be placed on epidermal powder immunization and particle-mediated ('gene gun') DNA immunization, which use similar mechanical devices to deliver protein and DNA vaccines, respectively, into the viable epidermis... - Epidermal powder immunization of mice and monkeys with an influenza vaccineDexiang Chen
PowderJect Vaccines, Inc, 585 Science Drive, Madison, WI 53711, USA
Vaccine 21:2830-6. 2003..This study suggests that EPI is a promising technique for administering human vaccine and that QS-21 augments the immunogenicity of co-administered influenza vaccine... - Hepatitis-B surface antigen (HBsAg) powder formulation: process and stability assessmentYuh Fun Maa
PowderJect Vaccines, Inc, 8551 Research Way Boulevard, Middleton, WI 53562, USA
Curr Drug Deliv 4:57-67. 2007..Further, a systematic formulation development strategy allowed the development and optimization of an HBsAg dry powder formulation, demonstrating excellent long-term physical, biochemical, and immunological stability... - Optimization of an alum-adsorbed vaccine powder formulation for epidermal powder immunizationYuh Fun Maa
PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
Pharm Res 20:969-77. 2003..To develop stable and effective aluminum salt (alum)-adsorbed vaccine powder formulations for epidermal powder immunization (EPI) via a spray freeze-drying (SFD) process... - Influenza vaccine powder formulation development: spray-freeze-drying and stability evaluationYuh Fun Maa
PowderJect Vaccines, Incorporated, 8551 Research Way Boulevard, Middleton, Wisconsin 53562, USA
J Pharm Sci 93:1912-23. 2004..More important, this study led to the selection of a formulation system that had been successfully tested in a human clinical study... - Stabilization of alum-adjuvanted vaccine dry powder formulations: mechanism and applicationYuh Fun Maa
PowderJect Vaccines, Inc 585 Science Drive, Madison, Wisconsin 53711, USA
J Pharm Sci 92:319-32. 2003..Therefore, SFD presents a novel and effective drying process for alum-adjuvanted vaccine formulations and is particularly valuable for dry powder applications such as EPI... - Immune responses to hepatitis B surface antigen following epidermal powder immunizationJorge E Osorio
PowderJect Vaccines Inc, Madison, Wisconsin, USA
Immunol Cell Biol 81:52-8. 2003..These results show that epidermal powder immunization is a safe and effective method to deliver hepatitis B surface antigen and the addition of new adjuvants, such as CpG DNA, may further enhance the efficacy of this vaccine... - Epidermal powder immunization using non-toxic bacterial enterotoxin adjuvants with influenza vaccine augments protective immunityDexiang Chen
PowderJect Vaccines Inc, 585 Science Drive, Madison, WI 53711, USA
Vaccine 20:2671-9. 2002..These adjuvants were well-tolerated both locally and systemically following EPI. These results suggest that EPI with influenza vaccine and a non-toxic bacterial enterotoxin hold promise for human vaccination... - A protective effect of epidermal powder immunization in a mouse model of equine herpesvirus-1 infectionTakashi Kondo
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
Virology 318:414-9. 2004..These findings indicate that the powder vaccine is a promising approach for the immunological control of EHV-1 infection, either alone or as a part of prime-boost vaccination strategies... - An antigen-independent but not antigen-specific T(H)1 response provides protection in the murine airway inflammation modelMelissa S Burger
PowderJect Vaccines, Inc, Seattle, WA, USA
J Allergy Clin Immunol 114:1301-8. 2004..CONCLUSION: This finding argues against the approach of boosting an allergen-dependent T(H)1 response and favors induction of an antigen-independent T(H)1 response for allergy immunotherapy... - Peptide induces CD4(+)CD25+ and IL-10+ T cells and protection in airway allergy modelsCindy L Zuleger
PowderJect Vaccines Inc, Middleton, WI 53562, USA
Vaccine 23:3181-6. 2005..Thus, intravenous delivery of a single peptide epitope is capable of inducing peripheral tolerance and protection in a complex allergy model, possibly through regulatory T cells and bystander suppression... - Epidermal powder immunization against influenzaHansi J Dean
PowderJect Vaccines, Inc, 8551 Research Way, Middleton, WI 53562, USA
Vaccine 23:681-6. 2004..Powdered influenza vaccine delivered by EPI is safe and elicits humoral immune responses in humans... - Spray-coating for biopharmaceutical powder formulations: beyond the conventional scale and its applicationYuh Fun Maa
PowderJect Vaccines, Inc, 585 Science Drive, Madison, Wisconsin 53711, USA
Pharm Res 21:515-23. 2004..Protein stability was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The immunogenicity of the vaccine was evaluated in vivo by needle injection and epidermal powder immunization (EPI) of mice or guinea pigs...