A Thorarensen

Summary

Affiliation: Pharmacia and Upjohn
Country: USA

Publications

  1. ncbi Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition
    A Thorarensen
    Medicinal Chemistry 7254 209 615, Pharmacia, Kalamazoo, MI 49001 0199, USA
    Bioorg Med Chem Lett 11:1355-8. 2001
  2. ncbi 3-Arylpiperidines as potentiators of existing antibacterial agents
    A Thorarensen
    Medicinal Chemistry, Pharmacia, 49007 4940, Kalamazoo, MI, USA
    Bioorg Med Chem Lett 11:1903-6. 2001
  3. ncbi Enols as potent antibacterial agents
    A Thorarensen
    Department of Medicinal Chemistry, Pharmacia, 7254 209 615, Kalamazoo, MI 49007 4940, USA
    Bioorg Med Chem Lett 11:2931-4. 2001

Detail Information

Publications3

  1. ncbi Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition
    A Thorarensen
    Medicinal Chemistry 7254 209 615, Pharmacia, Kalamazoo, MI 49001 0199, USA
    Bioorg Med Chem Lett 11:1355-8. 2001
    ..In addition, we identified an alternative class of PDF inhibitors, the N-hydroxy urea 18, which has both PDF and antibacterial activity...
  2. ncbi 3-Arylpiperidines as potentiators of existing antibacterial agents
    A Thorarensen
    Medicinal Chemistry, Pharmacia, 49007 4940, Kalamazoo, MI, USA
    Bioorg Med Chem Lett 11:1903-6. 2001
    ..Removal of the fluorine has a modest effect on antibiotic accumulation and the defluorinated analogue 17 is equally potent to the original lead 1...
  3. ncbi Enols as potent antibacterial agents
    A Thorarensen
    Department of Medicinal Chemistry, Pharmacia, 7254 209 615, Kalamazoo, MI 49007 4940, USA
    Bioorg Med Chem Lett 11:2931-4. 2001
    ..The SAR observations have been utilized to design a bioisostere for the alpha-trifluoroketoacetamide with good activity against Gram-positive organisms...