Jeffery J Prusakiewicz

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi Parabens inhibit human skin estrogen sulfotransferase activity: possible link to paraben estrogenic effects
    Jeffery J Prusakiewicz
    Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd, 20 342S D, Ann Arbor, MI 48105, USA
    Toxicology 232:248-56. 2007
  2. ncbi Comparison of skin esterase activities from different species
    Jeffery J Prusakiewicz
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd, Ann Arbor, Michigan 48105, USA
    Pharm Res 23:1517-24. 2006
  3. ncbi Comparison of paraben stability in human and rat skin
    Heather M Harville
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd, Ann Arbor, MI 48105, USA
    Drug Metab Lett 1:17-21. 2007
  4. ncbi The distribution of esterases in the skin of the minipig
    Christopher Jewell
    Toxicology Unit, School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4EA, UK
    Toxicol Lett 173:118-23. 2007
  5. ncbi Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture
    Christopher Jewell
    Toxicology Unit, School of Clinical and Laboratory Sciences, Devonshire Building, Newcastle University, Newcastle upon Tyne, NE2 4EA, UK
    Toxicol Appl Pharmacol 225:221-8. 2007
  6. ncbi Isoform-selective interaction of cyclooxygenase-2 with indomethacin amides studied by real-time fluorescence, inhibition kinetics, and site-directed mutagenesis
    Sergei L Timofeevski
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 41:9654-62. 2002
  7. ncbi Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2
    Jeffery J Prusakiewicz
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 296:612-7. 2002
  8. ncbi Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 42:9041-9. 2003
  9. ncbi Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin
    Jeffery J Prusakiewicz
    A. B. Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 43:15439-45. 2004

Collaborators

  • Yanhua Zhang
  • Christopher Jewell
  • Faith M Williams
  • Richard Voorman
  • Gwendolyn Fate
  • Chrisita Ackermann
  • N Ann Payne
  • Heather M Harville
  • Kevin R Kozak
  • Lawrence J Marnett
  • Sergei L Timofeevski
  • Daniel R Prudhomme
  • Scott W Rowlinson
  • Carol A Rouzer

Detail Information

Publications9

  1. ncbi Parabens inhibit human skin estrogen sulfotransferase activity: possible link to paraben estrogenic effects
    Jeffery J Prusakiewicz
    Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd, 20 342S D, Ann Arbor, MI 48105, USA
    Toxicology 232:248-56. 2007
    ..Accordingly, the skin anti-aging benefits of many topical cosmetics and pharmaceuticals could be derived, in part, from the estrogenicity of parabens...
  2. ncbi Comparison of skin esterase activities from different species
    Jeffery J Prusakiewicz
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd, Ann Arbor, Michigan 48105, USA
    Pharm Res 23:1517-24. 2006
    ..The aims of this study were to evaluate the suitability of minipig and rat skin as in vitro models of human epidermal esterase activity...
  3. ncbi Comparison of paraben stability in human and rat skin
    Heather M Harville
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd, Ann Arbor, MI 48105, USA
    Drug Metab Lett 1:17-21. 2007
    ..The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin...
  4. ncbi The distribution of esterases in the skin of the minipig
    Christopher Jewell
    Toxicology Unit, School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4EA, UK
    Toxicol Lett 173:118-23. 2007
    ..This study supports the use of the minipig, with topical application to the back, as a model for the investigation of pharmacokinetics and metabolism of ester prodrugs...
  5. ncbi Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture
    Christopher Jewell
    Toxicology Unit, School of Clinical and Laboratory Sciences, Devonshire Building, Newcastle University, Newcastle upon Tyne, NE2 4EA, UK
    Toxicol Appl Pharmacol 225:221-8. 2007
    ..These results demonstrate that the minipig is a suitable model for man for assessing dermal absorption and hydrolysis of parabens, although the carboxylesterase profile in skin differs between human and minipig...
  6. ncbi Isoform-selective interaction of cyclooxygenase-2 with indomethacin amides studied by real-time fluorescence, inhibition kinetics, and site-directed mutagenesis
    Sergei L Timofeevski
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 41:9654-62. 2002
    ..The indomethacin conjugates described herein represent powerful tools for the investigation of a novel class of selective inhibitors of COX-2...
  7. ncbi Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2
    Jeffery J Prusakiewicz
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 296:612-7. 2002
    ..These results suggest a possible role for COX-2 in the regulation of NAGly levels and the formation of a novel class of eicosanoids from NAGly metabolism...
  8. ncbi Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 42:9041-9. 2003
    ..Coupled with earlier observations with the endocannabinoid 2-arachidonylglycerol, these results indicate that one possible function of the highly conserved COX-2 active site side pocket is to promote endocannabinoid oxygenation...
  9. ncbi Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin
    Jeffery J Prusakiewicz
    A. B. Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 43:15439-45. 2004
    ..These results highlight binding of the 2'-methyl of INDO in the hydrophobic pocket as an important determinant of its time-dependent inhibition of COX enzymes...