Mark P Molloy

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi Overcoming technical variation and biological variation in quantitative proteomics
    Mark P Molloy
    Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
    Proteomics 3:1912-9. 2003
  2. ncbi Large-scale evaluation of quantitative reproducibility and proteome coverage using acid cleavable isotope coded affinity tag mass spectrometry for proteomic profiling
    Mark P Molloy
    Pfizer Global Research and Development, Department of Molecular Technologies, Michigan Laboratories, Ann Arbor, MI, USA
    Proteomics 5:1204-8. 2005
  3. ncbi Isolation of bacterial cell membranes proteins using carbonate extraction
    Mark P Molloy
    Australian Proteome Analysis Facility Ltd, Sydney, Australia
    Methods Mol Biol 424:397-401. 2008
  4. ncbi Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes
    Jianxin Yang
    Pfizer Global Research and Development, Groton, CT, USA
    BMC Genomics 12:281. 2011
  5. ncbi Proteomics: technologies and applications
    Mark P Molloy
    Pfizer Global Research and Development, Ann Arbor Laboratories, USA
    Brief Funct Genomic Proteomic 1:23-39. 2002
  6. ncbi Proteomic analysis of mdx skeletal muscle: Great reduction of adenylate kinase 1 expression and enzymatic activity
    Yue Ge
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, 48109, USA
    Proteomics 3:1895-903. 2003
  7. ncbi Profiling the alkaline membrane proteome of Caulobacter crescentus with two-dimensional electrophoresis and mass spectrometry
    Mark P Molloy
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proteomics 2:899-910. 2002
  8. ncbi Exploring the proteome: reviving emphasis on quantitative protein profiling
    Ruth A VanBogelen
    Proteomics 3:1833-4. 2003
  9. ncbi The challenge of industrializing proteomics
    Mark P Molloy
    Nat Biotechnol 21:597. 2003
  10. ncbi Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy
    Rohit G Saldanha
    Australian Proteome Analysis Facility Ltd and Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, 2109, NSW Australia
    J Proteome Res 6:1016-28. 2007

Collaborators

Detail Information

Publications12

  1. ncbi Overcoming technical variation and biological variation in quantitative proteomics
    Mark P Molloy
    Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
    Proteomics 3:1912-9. 2003
    ....
  2. ncbi Large-scale evaluation of quantitative reproducibility and proteome coverage using acid cleavable isotope coded affinity tag mass spectrometry for proteomic profiling
    Mark P Molloy
    Pfizer Global Research and Development, Department of Molecular Technologies, Michigan Laboratories, Ann Arbor, MI, USA
    Proteomics 5:1204-8. 2005
    ..However, the method was strongly biased to detect acidic proteins (pI < 7), under-represented small proteins (<10 kDa) and failed to show clear superiority over 2-DE methods in monitoring hydrophobic proteins from cell lysates...
  3. ncbi Isolation of bacterial cell membranes proteins using carbonate extraction
    Mark P Molloy
    Australian Proteome Analysis Facility Ltd, Sydney, Australia
    Methods Mol Biol 424:397-401. 2008
    ..With the aid of strong sample solubilising reagents compatible with two-dimensional electrophoresis (2-DE), many of the carbonate-enriched membrane proteins can be separated using standard 2-DE techniques...
  4. ncbi Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes
    Jianxin Yang
    Pfizer Global Research and Development, Groton, CT, USA
    BMC Genomics 12:281. 2011
    ..We sought to determine the hepatic & systemic consequence of full glucagon receptor antagonism through the study of the glucagon receptor knock-out mouse (Gcgr-/-) compared to wild-type littermates...
  5. ncbi Proteomics: technologies and applications
    Mark P Molloy
    Pfizer Global Research and Development, Ann Arbor Laboratories, USA
    Brief Funct Genomic Proteomic 1:23-39. 2002
    ..Some areas where proteomics has delivered valuable biological insight will also be considered, and there will be a look towards future areas of development...
  6. ncbi Proteomic analysis of mdx skeletal muscle: Great reduction of adenylate kinase 1 expression and enzymatic activity
    Yue Ge
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, 48109, USA
    Proteomics 3:1895-903. 2003
    ..Our results suggested that decreased AK 1 expression and activity might result in redistribution of energy flow through the alternative CK system, thus a compensatory potential might limit cellular energy failure in mdx skeletal muscle...
  7. ncbi Profiling the alkaline membrane proteome of Caulobacter crescentus with two-dimensional electrophoresis and mass spectrometry
    Mark P Molloy
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proteomics 2:899-910. 2002
    ..crescentus membrane proteome. Our experiments point towards new options for proteomic researchers aiming to both extend the scope of analysis, and simplify methods of identifying proteins with high confidence...
  8. ncbi Exploring the proteome: reviving emphasis on quantitative protein profiling
    Ruth A VanBogelen
    Proteomics 3:1833-4. 2003
  9. ncbi The challenge of industrializing proteomics
    Mark P Molloy
    Nat Biotechnol 21:597. 2003
  10. ncbi Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy
    Rohit G Saldanha
    Australian Proteome Analysis Facility Ltd and Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, 2109, NSW Australia
    J Proteome Res 6:1016-28. 2007
    ..Our findings support the notion that uPAR behaves as a lynchpin in promoting tumorigenesis by forming functionally active multiprotein complexes...
  11. ncbi Comparing SILAC and two-dimensional gel electrophoresis image analysis for profiling urokinase plasminogen activator signaling in ovarian cancer cells
    Pauliina M Uitto
    Department of Chemistry and Biomolecular Sciences, Macquarie University, 2109, Sydney, NSW, Australia
    J Proteome Res 6:2105-12. 2007
    ..However, due to the lower variances associated with the SILAC technique, smaller changes in expression of uPA-inducible proteins could be found with greater certainty...
  12. ncbi Differential expression of the skeletal muscle proteome in mdx mice at different ages
    Yue Ge
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor 48109-0606, USA
    Electrophoresis 25:2576-85. 2004
    ..Finally, we analyzed alterations of protein expression in mdx mice at one and six months of age to determine how protein expression changes with disease progression...