Research Topics
| R E ChapinSummaryAffiliation: Pfizer Global Research and Development Country: USA Publications
| Collaborators
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Detail Information
Publications
Our once-in-a-lifetime opportunityRobert E Chapin
Reproductive and Developmental Toxicology Group, Pfizer Global Research and Development, Safety Sciences, Eastern Point Road, MS 8274 1336, Groton, CT 06340, USA
Environ Health Perspect 112:67-8. 2004....- Nature is complex: our orchestra seats at the most wonderful show on earthRobert E Chapin
Pfizer Global Res. and Development, Groton, CT 06340, USA
Toxicol Sci 80:1-2. 2004 - NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol ARobert E Chapin
Pfizer, Inc, Groton, CT, USA
Birth Defects Res B Dev Reprod Toxicol 83:157-395. 2008 - The use of the rat in developmental immunotoxicology studiesR E Chapin
Pfizer Global R and D, Drug Safety Evaluation, Eastern Point Rd, MS 8274 1336, Groton, Connecticut 06340, USA
Hum Exp Toxicol 21:521-3. 2002..The benefits and costs are discussed for the possibility of using pups generated in breeding studies for additional assessments, such as evaluating immunotoxicity. Such an approach is logistically challenging, but not overwhelming... - Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's healthRobert E Chapin
Pfizer Global Research and Development, Safety Sciences, Eastern Point Road, MS 8274 1336, Groton, CT 06340, USA
Environ Health Perspect 112:69-78. 2004..Clearly, the time for analysis begins when the next generation is but a twinkle in the eye... - Effects of feed restriction during organogenesis on embryo-fetal development in rabbitG D Cappon
Pfizer Global Research and Development, Groton, Connecticut, USA
Birth Defects Res B Dev Reprod Toxicol 74:424-30. 2005..To aid with this, the effects of feed restriction, and subsequent reduction in maternal body weight gain, on embryo-fetal development was investigated in the rabbit... - Effects of feed restriction on fertility in female ratsK K Terry
Pfizer Global Research and Development, Groton, Connecticut 06340, USA
Birth Defects Res B Dev Reprod Toxicol 74:431-41. 2005..This study reports the effects of feed restriction in the context of an FDA regulatory submission... - The effects of feed restriction during organogenesis on embryo-fetal development in the ratT L Fleeman
Pfizer Global Research and Development, Groton, Connecticut 06340, USA
Birth Defects Res B Dev Reprod Toxicol 74:442-9. 2005..To aid with this, the effects of feed restriction and subsequent body weight reductions on embryo-fetal development were investigated in the rat... - Toxicological highlightsRobert E Chapin
Developmental and Reproductive Toxicology Center of Expertise, Pfizer Global R and D, Eastern Point Rd, Groton, CT 06340, USA
Toxicol Sci 98:311-2. 2007 - Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industryJennifer A Paquette
Pfizer Global Research and Development, Global DART, Groton New London Laboratories, Pfizer Inc, Groton, CT 06340, USA
Birth Defects Res B Dev Reprod Toxicol 83:104-11. 2008..An in vitro tool to assess developmental toxicity would be of great value to the pharmaceutical industry to help with toxicity-associated attrition... - Endless possibilities: stem cells and the vision for toxicology testing in the 21st centuryRobert E Chapin
Developmental and Reproductive Toxicology, Drug Safety R and D, Pfizer, Inc, Groton, Connecticut 06365, USA
Toxicol Sci 112:17-22. 2009..We expect that a long series of successive iterations of predictive models will eventually yield a working process that approximates the NRC's vision and delivers on the promise of faster evaluation of chemicals with reduced animal use... - Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal developmentChristopher J Bowman
Drug Safety Research and Development, Pfizer, Inc, Groton, Connecticut 06340, USA
Birth Defects Res B Dev Reprod Toxicol 89:339-49. 2010..Thus, all molecules (i.e., both small and large) that disrupt the IGF axis could be expected to have some degree of fetal consequences... - The pesticide methoxychlor given orally during the perinatal/juvenile period, reduced the spermatogenic potential of males as adults by reducing their Sertoli cell numberLarry Johnson
Department of Veterinary Anatomy and Public Health, Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843 4458, USA
Reprod Nutr Dev 42:573-80. 2002..01) correlated to reduced number of Sertoli cells per testis. Hence, perinatal and juvenile oral exposure to MXC can reduce spermatogenic potential of males as adults by reducing their number of Sertoli cells... - In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, MéxicoMatthew P Longnecker
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Am J Epidemiol 165:1015-22. 2007..If DDE has important antiandrogenic action in humans, it may be manifest only at higher levels of exposure or via effects on other outcomes... - Developmental toxicology evaluations--issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studiesGregory S Ladics
The DuPont Company, Haskell Laboratory, Newark, Delaware 19714, USA
Toxicol Sci 88:24-9. 2005..The group agreed to consider the HESI ACSA Life Stages Task Force recommendations as a next step to address some of the issues and challenges raised during this session... - NTP-CERHR expert panel report on the reproductive and developmental toxicity of acrylamideJeanne Manson
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Birth Defects Res B Dev Reprod Toxicol 74:17-113. 2005 - Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproduction, and toxicologyPaul S Cooke
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA
Toxicol Appl Pharmacol 194:309-35. 2004..Ray Witorsch summarizes the many effects of glucocorticoids on the reproductive system. Finally, Paul Sylvester reviews the mechanism of action of prolactin, and reminds us that this ancient hormone has many functions beyond lactation... - Recommended approaches for the evaluation of testicular and epididymal toxicityLynda L Lanning
BioReliance Corporation, Rockville, Maryland 20850, USA
Toxicol Pathol 30:507-20. 2002 - The hidden effect of estrogenic/antiandrogenic methoxychlor on spermatogenesisChristophe Staub
Department of Veterinary Anatomy and Public Health, Texas A and M University, College Station, TX 77843-4458, USA
Toxicol Appl Pharmacol 180:129-35. 2002..Given that endocrine disruptors like MXC can induce compensation during spermatogenesis, it may reduce the ability of the testis to compensate during subsequent exposures... - Development and maturation of the male reproductive systemM Sue Marty
Toxicology Research Laboratory, Dow Chemical Company, Midland, Michigan 48674, USA
Birth Defects Res B Dev Reprod Toxicol 68:125-36. 2003