Research Topics
Species | JOSHUA LAMBERTSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
A colored avocado seed extract as a potential natural colorantDeepti Dabas
Dept of Food Science, The Pennsylvania State Univ, Univ Park, PA 16802, USA
J Food Sci 76:C1335-41. 2011..Avocado seeds, which represent an under-utilized waste stream, form a stable orange color when crushed in the presence of air. Our data indicate that avocado seed represents a potential source of new natural colorants for use in foods...- Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallateJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Carcinogenesis 29:2019-24. 2008..These results further show the need for careful cancer prevention studies in animal models and for caution when interpreting data from in vitro studies... - Anticancer and anti-inflammatory effects of cysteine metabolites of the green tea polyphenol, (-)-epigallocatechin-3-gallateJoshua D Lambert
Department of Food Science, The Pennsylvania State University, 332 Food Science Building, University Park, Pennsylvania 16802, USA
J Agric Food Chem 58:10016-9. 2010..These results remain to be confirmed in vivo... - The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer preventionJoshua D Lambert
Department of Food Science, The Pennsylvania State University, University Park, PA 16802, USA
Arch Biochem Biophys 501:65-72. 2010..This review is meant point out understudied areas and stimulate research on the topic with the hope that insights into the mechanisms of cancer preventive activity of tea polyphenols will result... - Inhibition of lung cancer growth in mice by dietary mixed tocopherolsJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
Mol Nutr Food Res 53:1030-5. 2009..Further studies are needed to determine the underlying mechanisms for this anticancer activity, and to determine if such activity occurs in other models of cancer... - Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in miceJoshua D Lambert
Department of Food Science, The Pennsylvania State University, 332 Food Science Building, University Park, PA 16802, USA
Food Chem Toxicol 48:409-16. 2010.... - Antioxidative and anti-carcinogenic activities of tea polyphenolsChung S Yang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Arch Toxicol 83:11-21. 2009..Finally, we discuss the effects of tea consumption on cancer risk in humans. It is our aim to raise some of the unanswered questions regarding cancer prevention by tea and to stimulate further research in this area... - Mechanisms of cancer prevention by tea constituentsJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Nutr 133:3262S-3267S. 2003..Such discussion, it is hoped, will clarify some misunderstandings of cancer prevention by tea and stimulate new research efforts... - N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adductJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Free Radic Biol Med 44:1069-74. 2008..The present results show that under cell culture conditions, EGCG and NAC interact to form a previously unreported adduct, EGCG-2'-NAC, which may contribute to enhancement of EGCG-mediated cell killing... - Biotransformation of green tea polyphenols and the biological activities of those metabolitesJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Mol Pharm 4:819-25. 2007..We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability, biotransformation, and the biological activities of tea catechin metabolites... - Inhibition of carcinogenesis by tea constituentsJihyeung Ju
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Semin Cancer Biol 17:395-402. 2007..Human intervention trials are warranted to determine the possible prevention of cancer of specific sites by preparation of tea constituents... - Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extractMao-Jung Lee
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
Cancer Epidemiol Biomarkers Prev 13:132-7. 2004..These results indicate that tea leaves can be used as a convenient, slow-release source of catechins and theaflavins and provide information for the possible use of tea in the prevention of oral cancer and dental caries... - Cancer chemopreventive activity and bioavailability of tea and tea polyphenolsJoshua D Lambert
Department of Chemical Biology, Laboratory for Cancer Research, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Mutat Res 523:201-8. 2003..We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability and cancer chemoprevention... - Bioavailability issues in studying the health effects of plant polyphenolic compoundsChung S Yang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Mol Nutr Food Res 52:S139-51. 2008..Further research on both the biological activity and bioavailability of dietary polyphenols is needed to properly assess their usefulness for the prevention and treatment of disease... - Cancer prevention by tea and tea polyphenolsChung S Yang
Department of Chemical Biology, Ernest Mario School of Phar macy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
Asia Pac J Clin Nutr 17:245-8. 2008..Human intervention trials and large prospective studies are needed to further assess the cancer preventive activities of tea constituents... - Inhibition of intestinal tumorigenesis in Apc(min/+) mice by green tea polyphenols (polyphenon E) and individual catechinsXingpei Hao
Department of Chemical Biology, Ernest Mario School of Pharmacy Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Nutr Cancer 59:62-9. 2007..The results suggest that these molecular events contribute to the cancer prevention activity of EGCG and PPE. Furthermore, diet appears to be a better route of administration for PPE than drinking fluid... - Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallateJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Drug Metab Dispos 34:2111-6. 2006..4- and 6.0-fold, respectively). These data suggest that acetylation represents a means of increasing the biological potency in vitro, increasing the bioavailability of EGCG in vivo, and may improve cancer-preventive activity... - Redox properties of tea polyphenols and related biological activitiesShengmin Sang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Antioxid Redox Signal 7:1704-14. 2005.... - Tea and cancer prevention: molecular mechanisms and human relevanceChung S Yang
Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, and Center for Cancer Prevention Research, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Toxicol Appl Pharmacol 224:265-73. 2007..Some interesting examples in this area are discussed... - Effects of tea polyphenols on signal transduction pathways related to cancer chemopreventionZhe Hou
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
Mutat Res 555:3-19. 2004..It is likely that multiple signal transduction pathways are involved in the inhibition of carcinogenesis by tea constituents. The relative importance of these pathways needs to be determined in vivo... - Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivativesJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA
Bioorg Med Chem Lett 15:873-6. 2005..The possible antiinflammatory activity of 1 and its trimethoxy derivative was also evaluated. Neither compound inhibited the release of arachidonic acid, although 1 inhibited NO production by 50% at 20 microM... - Possible controversy over dietary polyphenols: benefits vs risksJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Chem Res Toxicol 20:583-5. 2007 - Molecular targets for the cancer preventive activity of tea polyphenolsChung S Yang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Mol Carcinog 45:431-5. 2006..Validating the related cancer preventive mechanisms found in in vitro studies in animal models and human samples would be exciting... - Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesityKimberly A Grove
Department of Food Science, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 140:446-53. 2010..We hope that this review will expose areas for further study and encourage research on this important public health issue... - Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigationsJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA
Am J Clin Nutr 81:284S-291S. 2005.... - Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to miceJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Nutr 133:4172-7. 2003..This is the first report of the pharmacokinetic parameters of EGCG in mice. Such information provides a basis for understanding the bioavailability of EGCG in mice and should aid in understanding the cancer preventive activity of EGCG... - Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oilMousumi Bose
Susan L Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
J Agric Food Chem 55:7695-700. 2007..The results indicate that a combination of low doses of EGCG and fish oil can inhibit tumor multiplicity in Apc (Min/+) mice... - Metabolism of dietary polyphenols and possible interactions with drugsJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Curr Drug Metab 8:499-507. 2007..The potential consequences of these effects on drug metabolism will also be discussed... - Possible mechanisms of the cancer-preventive activities of green teaChung S Yang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Mol Nutr Food Res 50:170-5. 2006..We also need to distinguish between primary and subsequent events. Possible artifacts should be recognized. The cancer-preventive mechanisms need to be validated in animal models or human samples... - The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed miceMousumi Bose
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Nutr 138:1677-83. 2008..Short-term EGCG treatment appeared to reverse preexisting high-fat-induced metabolic pathologies in obese mice. These effects may be mediated by decreased lipid absorption, decreased inflammation, and other mechanisms... - Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activitiesShengmin Sang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
Bioorg Med Chem 12:459-67. 2004..7 cells. Their cytotoxic activities against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated... - Cancer chemoprevention by targeting proteasomal degradation: commentary re KA Dragnev et al, Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. Clin Cancer Res, 2004;10:2570-7Chung S Yang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
Clin Cancer Res 10:2220-1. 2004 - Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studiesDapeng Chen
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Biochem Pharmacol 69:1523-31. 2005..These results provide mechanistic insight into the inhibition of COMT by commonly consumed tea catechins... - Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissuesJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854-8020, USA
Drug Metab Dispos 34:8-11. 2006..The present study provides information with respect to what concentrations of EGCG are achievable in mice and may guide dose selection for future cancer chemoprevention studies with EGCG... - Transdermal delivery of (-)-epigallocatechin-3-gallate, a green tea polyphenol, in miceJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Pharm Pharmacol 58:599-604. 2006..These data indicate that transdermal EGCG is useful for delivering prolonged levels of EGCG to plasma and tissues, and may provide an alternative to tea consumption as a dosage form of EGCG... - Synthesis and structure identification of thiol conjugates of (-)-epigallocatechin gallate and their urinary levels in miceShengmin Sang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey 08854-8020, USA
Chem Res Toxicol 18:1762-9. 2005..These results suggest that detectable amounts of thiol conjugates of EGCG are formed only after rather high doses of EGCG are given to the mice... - Salivary hydrogen peroxide produced by holding or chewing green tea in the oral cavityJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
Free Radic Res 41:850-3. 2007..2 microM). Salivary H(2)O(2) and catechin concentrations were similar to those that are biologically active in vitro. Catechin-generated H(2)O(2) may, therefore, have a role in disease prevention by green tea... - Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in miceJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA
J Nutr 134:1948-52. 2004..The present study demonstrates the modulation of the EGCG bioavailablity by a second dietary component and illustrates a mechanism for interactions between dietary chemicals... - (-)-Epigallocatechin-3-gallate increases the expression of genes related to fat oxidation in the skeletal muscle of high fat-fed miceSudathip Sae-Tan
Department of Food Science, The Pennsylvania State University, 332 Food Science Building, University Park, PA 16802, USA
Food Funct 2:111-6. 2011..In summary, it appears that EGCG modulates body weight gain in high fat-fed mice both by increasing the expression of genes related fat oxidation in the skeletal muscle and by modulating fat absorption from the diet... - Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolitesJungil Hong
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Biochem Biophys Res Commun 310:222-7. 2003..The results indicate that EGCG and its methyl metabolites are substrates for MRP1 and MRP2, but not for Pgp. MRP type efflux pumps may limit the bioavailability of EGCG... - A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated miceJihyeung Ju
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
Cancer Prev Res (Phila) 2:143-52. 2009.... - Benzotropolone inhibitors of estradiol methylation: kinetics and in silico modeling studiesJoshua D Lambert
Department of Chemical Biology Rutgers, Ernest Mario School of Pharmacy, The State University of New Jersey, 164 Frelinghuysen Rd, Piscataway, NJ 08854, USA
Bioorg Med Chem 13:2501-7. 2005..Further studies are needed to determine the impact in vivo of COMT inhibition by these compounds... - Wheat bran oil and its fractions inhibit human colon cancer cell growth and intestinal tumorigenesis in Apc(min/+) miceShengmin Sang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854-8020, USA
J Agric Food Chem 54:9792-7. 2006..The current results demonstrate, for the first time, the intestinal cancer preventive activity of WB oil. The active ingredients, however, remain to be identified... - Cytotoxic lignans from Larrea tridentataJoshua D Lambert
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Phytochemistry 66:811-5. 2005..The relative potency of linear butane type lignans against human breast cancer appears to correlate positively with the number of O-methyl groups present on the molecule...
Research Grants
- Fatty Liver Preventive Effects and High Dose Hepatotoxicity of Tea PolyphenolsJOSHUA LAMBERT; Fiscal Year: 2009..e. preexisting fatty liver disease) in which individuals may be sensitized to the hepatotoxic effects of EGCG. ..
- Fatty Liver Preventive Effects and High Dose Hepatotoxicity of Tea PolyphenolsJoshua D Lambert; Fiscal Year: 2010..e. preexisting fatty liver disease) in which individuals may be sensitized to the hepatotoxic effects of EGCG. ..