Research Topics
Genomes and Genes | Z C LaiSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
Control of cell proliferation and apoptosis by mob as tumor suppressor, matsZhi Chun Lai
Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
Cell 120:675-85. 2005..A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in Drosophila. As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans...- Repression of Drosophila photoreceptor cell fate through cooperative action of two transcriptional repressors Yan and TramtrackZ C Lai
Department of Biology, The Pennsylvania State University, University Park 16802, USA
Genetics 147:1131-7. 1997..Reduction of either yan or ttk activity suppresses eye phenotypes of the kinase suppressor of ras (ksr) gene mutation, which is consistent with the involvement of yan and ttk in the Ras/MAPK pathway... - The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eyeY Wen
Department of Biology and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Genetics 156:195-203. 2000..A dCtBP consensus binding motif in the C terminus appears to contribute to Ttk69 activity, but it cannot be fully responsible for the function of the C terminus... - Tramtrack69 is positively and autonomously required for Drosophila photoreceptor developmentZ C Lai
Department of Biology and Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Genetics 152:299-305. 1999..Thus, Ttk69 appears to play a dual function by serving negative and positive regulatory roles at different stages of photoreceptor development... - Evolutionary conservation of the leucine-rich repeat transmembrane protein Gp150 in Drosophila and BombyxD Dhulkotia
Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA
Dev Genes Evol 210:145-50. 2000..This is further corroborated by the localization of gp150 transcripts in eye imaginal discs in the region spanning the morphogenetic furrow... - Evolution of functional diversification of the paired box (Pax) DNA-binding domainsK A Balczarek
Department of Biology, Pennsylvania State University, University Park 16802, USA
Mol Biol Evol 14:829-42. 1997..Implications of such fixed amino acid differences in potentially generating sequence recognition specificities are discussed in the context of some recent experimental findings... - Evolution of the hedgehog gene familyS Kumar
Department of Biology, Pennsylvania State University 16802, USA
Genetics 142:965-72. 1996.... - Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant backgroundZ C Lai
Howard Hughes Medical Institute, University of California, Berkeley, 94720 3200, USA
Proc Natl Acad Sci U S A 93:5025-30. 1996..In particular, TTK activity appears to be autonomously required to regulate a sina-independent mechanism of R7 determination... - The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifsM E Fortini
Howard Hughes Medical Institute, University of California, Berkeley 94720
Mech Dev 34:113-22. 1991..The novel arrangement of interspersed homeodomain and zinc-finger motifs in the primary sequences of the zfh-1 and zfh-2 gene products may signify an unusual mechanism of transcriptional regulation by these proteins... - The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteinsZ C Lai
Howard Hughes Medical Institute, University of California, Berkeley 94720
Mech Dev 34:123-34. 1991..The expression patterns of zfh-1 and zfh-2 suggest that both genes may be involved in Drosophila neurogenesis and that zfh-1 may have additional functions in mesoderm development... - Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signalingR van Huizen
Departments of Physiology and Neuroscience, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, WBSB 216, Baltimore, MD 21205, USA
EMBO J 17:2285-97. 1998..Such domain organization allows for the multivalent INAD-NORPA interactions which are essential for G protein-coupled phototransduction... - Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor TramtrackS Li
Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
Cell 90:469-78. 1997..These results argue that photoreceptor differentiation is regulated by the RAS pathway through targeted proteolysis of the TTK repressor... - Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive geneJ E Treisman
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Development 121:2835-45. 1995..shortsighted encodes a cytoplasmic leucine zipper protein with homology to a mouse gene, TSC-22, which is transcriptionally induced in response to TGF-beta... - Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissuesZ C Lai
Howard Hughes Medical Institute, University of California, Berkeley 94720
Proc Natl Acad Sci U S A 90:4122-6. 1993..Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning... - Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain proteinZ C Lai
Howard Hughes Medical Institute, University of California, Berkeley 94720
Cell 70:609-20. 1992..Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1... - Isolation, characterization, and expression of the gene encoding the late histone subtype H1-gamma of the sea urchin Strongylocentrotus purpuratusJ A Knowles
Mol Cell Biol 7:478-85. 1987..4 X 10(5) H1-gamma mRNAs by 82 h postfertilization. Surprisingly, the number of late H1 mRNA molecules per embryo is greater than the number of late H2B mRNA molecules beginning at the early gastrula stage of development... - Characterization of the structure and transcriptional patterns of the gene encoding the late histone subtype H1-beta of the sea urchin Strongylocentrotus purpuratusZ C Lai
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
Mol Cell Biol 8:1842-4. 1988..The expression of H1-beta mRNA is coordinated with that of H1-gamma mRNA, and like H1-gamma it is expressed in all adult somatic tissues tested...