Gregory S Yochum

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4
    Gregory S Yochum
    Vollum Institute, Division of Biostatistics, Department of Public Health and Preventative Medicine, OHSU Cancer Institute, Oregon Health and Science University, Portland 97239, USA
    J Biol Chem 282:871-8. 2007
  2. ncbi Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells
    Gregory S Yochum
    Department of Public Health and Preventative Medicine, and Oregon Health and Science University Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 104:3324-9. 2007
  3. ncbi A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression
    Gregory S Yochum
    Vollum Institute and Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Mol Cell Biol 28:7368-79. 2008
  4. ncbi Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions
    Soren Impey
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Cell 119:1041-54. 2004
  5. ncbi Localization of TFIIB binding regions using serial analysis of chromatin occupancy
    Gregory S Yochum
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    BMC Mol Biol 8:102. 2007
  6. ncbi Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq
    Daniel Bottomly
    Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, OR, USA
    Nucleic Acids Res 38:5735-45. 2010
  7. ncbi A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers
    Gregory S Yochum
    Vollum Institute and Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 107:145-50. 2010
  8. ncbi Cell-type-specific binding of the transcription factor CREB to the cAMP-response element
    Hyunjoo Cha-Molstad
    Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 101:13572-7. 2004
  9. ncbi A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions
    Stefanie J Otto
    Howard Hughes Medical Institute, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
    J Neurosci 27:6729-39. 2007
  10. ncbi Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split
    Gregory S Yochum
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Mol Cell Biol 22:7868-76. 2002

Collaborators

Detail Information

Publications10

  1. ncbi An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4
    Gregory S Yochum
    Vollum Institute, Division of Biostatistics, Department of Public Health and Preventative Medicine, OHSU Cancer Institute, Oregon Health and Science University, Portland 97239, USA
    J Biol Chem 282:871-8. 2007
    ..We propose that Wnt/beta-catenin signaling may contribute to colorectal carcinogenesis by reducing the level of the E2F4 cell cycle repressor via an antisense mechanism...
  2. ncbi Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells
    Gregory S Yochum
    Department of Public Health and Preventative Medicine, and Oregon Health and Science University Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 104:3324-9. 2007
    ..Furthermore, 15 components of the canonical Wnt pathway were identified as beta-catenin target genes, suggesting that feed-forward and feedback mechanisms exist to modulate the Wnt signal in colon cancer cells...
  3. ncbi A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression
    Gregory S Yochum
    Vollum Institute and Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Mol Cell Biol 28:7368-79. 2008
    ..Our findings indicate that a downstream enhancer element provides the principal regulation of c-Myc expression...
  4. ncbi Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions
    Soren Impey
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Cell 119:1041-54. 2004
    ..A large fraction of the SACO loci delineated bidirectional promoters and novel antisense transcripts. This study represents the most comprehensive definition of transcription factor binding sites in a metazoan species...
  5. ncbi Localization of TFIIB binding regions using serial analysis of chromatin occupancy
    Gregory S Yochum
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    BMC Mol Biol 8:102. 2007
    ..Serial analysis of chromatin occupancy (SACO) is an unbiased methodology used to empirically identify transcription factor binding regions. In this report, we use TFIIB and SACO to localize TFIIB binding regions across the rat genome...
  6. ncbi Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq
    Daniel Bottomly
    Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, OR, USA
    Nucleic Acids Res 38:5735-45. 2010
    ..Our work provides evidence that Wnt/?-catenin and mitogen signaling pathways intersect directly to regulate a defined set of target genes...
  7. ncbi A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers
    Gregory S Yochum
    Vollum Institute and Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 107:145-50. 2010
    ..Thus, we propose that a distinct chromatin architecture coordinated by beta-catenin/TCF-bound WREs accompanies transcriptional activation of MYC gene expression...
  8. ncbi Cell-type-specific binding of the transcription factor CREB to the cAMP-response element
    Hyunjoo Cha-Molstad
    Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 101:13572-7. 2004
    ..We conclude that the family of CREB target genes differs from one cell type to another and that the ability of CREB to bind to a particular CRE represents an important component of gene regulation...
  9. ncbi A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions
    Stefanie J Otto
    Howard Hughes Medical Institute, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
    J Neurosci 27:6729-39. 2007
    ..Unexpectedly, genes considered exclusively non-neuronal also contained an RE1 motif and were expressed in neurons. This supports the model that REST binding is a critical determinant of neuronal phenotype...
  10. ncbi Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split
    Gregory S Yochum
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Mol Cell Biol 22:7868-76. 2002
    ..In addition, Pf1 and MRG15 bind different domains on mSin3A. Together, these data suggest that the unique functions of MRG15 are elicited through the action of an MRG15/Pf1/mSin3A complex...