Research Topics
Species | Gayle A OrnerSummaryAffiliation: Oregon State University Country: USA Publications
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Publications
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of ratsGayle A Orner
Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
J Carcinog 5:6. 2006..The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats...- Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindacGayle A Orner
Linus Pauling Institute and Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 24:263-7. 2003.... - Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)Gayle A Orner
Department of Environmental and Molecular Toxicology, 571 Weniger Hall, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA
Mutat Res 506:121-7. 2002..Collectively, the data support a chemopreventive role for tea and sulindac against intermediate and late stages of colon cancer, via effects on the beta-catenin/Tcf signaling pathway... - Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow troutSusan C Tilton
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA
Environ Health Perspect 116:1047-55. 2008..Previous studies with rainbow trout indicate they are also insensitive to peroxisome proliferation by the PP dehydroepiandrosterone (DHEA), but are still susceptible to enhanced hepatocarcinogenesis after chronic exposure... - Tumor-suppressing effects of antioxidants from teaGayle A Orner
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr 134:3177S-3178S. 2004 - Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the ratMichael T Simonich
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 28:1294-302. 2007..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon... - Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeineDavid J Castro
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 29:1581-6. 2008..This is the first demonstration that maternal ingestion of green tea, during pregnancy and nursing, provides protection against transplacental carcinogenesis... - Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker studyGeorge S Bailey
Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center, Linus Pauling Institute, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
Chem Res Toxicol 22:1264-76. 2009..They provide the first experimental estimation in any model of the degree of conservatism that may exist for the EPA default linear assumption for a genotoxic carcinogen... - Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signalingCarmen A Blum
Department of Environmental and Molecular Toxicology, Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331-6512, USA
Mutat Res 523:217-23. 2003.... - Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow troutSusan C Tilton
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 28:1589-98. 2007..They confirm the importance of estrogenic signaling in the mechanism of promotion by dietary indoles in trout liver and indicate a possible dual effect that enhances tumor incidence and decreases potential for metastasis... - Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus miceMelinda C Myzak
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
FASEB J 20:506-8. 2006.... - Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrationsWan-Mohaiza Dashwood
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA
Biochem Biophys Res Commun 296:584-8. 2002..These data are consistent with the findings from in vivo studies, showing the suppression of intestinal polyps by tea, via an apparent down-regulation of beta-catenin and Wnt target genes... - The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promotersDavid E William
Marine Freshwater Biomedical Sciences Center, Oregon State University, Corvallis, Oregon, USA
Toxicol Pathol 31:58-61. 2003..If these results can be confirmed with other carcinogens (genotoxic and perhaps nongenotoxic) and other targets, this could have a significant impact on the utilization of animal tumor data in human risk assessment... - Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant cryptsOrianna Carter
Ohio University Southern, 1804 Liberty Avenue, Ironton, OH 45638, USA
Nutr Cancer 58:60-5. 2007..5 +/- 0.4 (P > 0.05, not significant). The data imply that white tea, caffeine, and EGCG may be most effective post-initiation, via the inhibition of cell proliferation in the colon and through the suppression of early lesions...