Research Topics
Genomes and Genes
Species | Jennifer M LoftisSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Publications
Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1beta and tumor necrosis factor-alphaJennifer M Loftis
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA
Neurosci Lett 430:264-8. 2008..Future studies should investigate how inflammatory mediators play a role in the expression of specific depressive symptoms in patients with chronic infection. Patients with HCV represent an interesting model to examine this relationship...- The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implicationsJennifer M Loftis
Research Service, Department of Veterans Affairs Medical Center, Mental Health P3MHDC, 3710 SW U S Veterans Hospital Road, Portland, OR 97201, USA
Pharmacol Ther 97:55-85. 2003..The review concludes with a section discussing the role of NR2B in human diseases... - Neuroimmune mechanisms of cytokine-induced depression: current theories and novel treatment strategiesJennifer M Loftis
Research and Development Service, Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, USA
Neurobiol Dis 37:519-33. 2010..Future research should aim to characterize these depression-related symptom constellations or syndromes better with the goal of optimizing treatment strategies... - Methamphetamine causes persistent immune dysregulation: a cross-species, translational reportJennifer M Loftis
Research and Development Service, Portland VA Medical Center, 3710 SW U S Veterans Hospital Rd, R and D 16, Portland, OR 97239, USA
Neurotox Res 20:59-68. 2011..This cross-species, translational study suggests that chronic CNS immune dysregulation may in part contribute to the longlasting neuropsychiatric consequences of MA dependence... - The phenomenology and treatment of interferon-induced depressionJennifer M Loftis
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR, USA
J Affect Disord 82:175-90. 2004..Screening and monitoring, ideally using symptom rating scales for depression, and early antidepressant treatment intervention appear necessary to optimize IFN therapy for the majority of patients... - Antiviral completion rates and sustained viral response in hepatitis C patients with and without preexisting major depressive disorderPeter Hauser
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, OR 97202, USA
Psychosomatics 50:500-5. 2009..Despite evidence suggesting that the majority of patients with hepatitis C virus (HCV) have psychiatric and substance use disorders, patients with these comorbidities have historically been excluded from antiviral therapy for HCV... - Interferon alpha therapy for hepatitis C: treatment completion and response rates among patients with substance use disordersMarilyn S Huckans
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, USA
Subst Abuse Treat Prev Policy 2:4. 2007.... - Prophylactic antidepressant treatment in patients with hepatitis C on antiviral therapy: a double-blind, placebo-controlled trialBenjamin J Morasco
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR 97239, USA
Psychosomatics 51:401-8. 2010..Approximately one-third of patients undergoing interferon-? (IFN-?) therapy for treatment of the hepatitis C virus (HCV) develop major depression, which decreases functioning and may lead to the reduction or discontinuation of treatment... - Predictors of pain intensity and pain functioning in patients with the hepatitis C virusBenjamin J Morasco
Northwest Hepatitis C Resource Center and Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR 97239, USA
Gen Hosp Psychiatry 32:413-8. 2010..To examine the relationships among biological and psychological variables with pain intensity and pain functioning in patients with the hepatitis C virus (HCV)... - The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophreniaMarilyn Huckans
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, OR, USA
Antivir Ther 15:111-9. 2010..The aim of this study was to determine whether antiviral therapy is associated with higher rates of psychiatric symptoms in patients with schizophrenia (SCHZ)... - Depression comorbidity and antidepressant use in veterans with chronic hepatitis C: results from a retrospective chart reviewJulie A Nelligan
Northwest Hepatitis C Resource Center, Behavioral Health and Clinical Neurosciences Division, Portland Department of Veterans Affairs VA Medical Center, Oregon Health and Science University, Portland, Oregon 97207, USA
J Clin Psychiatry 69:810-6. 2008..In this study we characterize the prevalence and severity of co-morbid depression, as well as antidepressant and other psychotropic prescribing patterns, in a sample of U.S. veterans with HCV... - A randomized trial of paroxetine to prevent interferon-alpha-induced depression in patients with hepatitis CBenjamin J Morasco
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Oregon, United States
J Affect Disord 103:83-90. 2007..This study examined the efficacy of paroxetine in preventing the development of depression during antiviral therapy... - Psychiatric and substance use disorders comorbidities in veterans with hepatitis C virus and HIV coinfectionBret E Fuller
Mental Health Division, Portland Veterans Affairs Medical Center, Portland, Oregon 97210, USA
Curr Opin Psychiatry 22:401-8. 2009..This review covers timely research relative to comorbid conditions that are common in this population including psychiatric diagnoses, substance use disorders and neurocognitive problems... - The cognitive effects of hepatitis C in the presence and absence of a history of substance use disorderMarilyn Huckans
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, Oregon 97239, USA
J Int Neuropsychol Soc 15:69-82. 2009..Results indicate that chronic HCV is associated with cognitive impairment in the absence of a history of SUD. The most robust deficits appear to be in verbal learning and reasoning/mental flexibility. (JINS, 2009, 15, 69-82.)... - Screening for depression in patients with hepatitis C using the Beck Depression Inventory-II: do somatic symptoms compromise validity?Alexander L Patterson
Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR, USA
Gen Hosp Psychiatry 33:354-62. 2011..The objective of the study was to evaluate the validity of the Beck Depression Inventory-II (BDI-II) when used to measure depression in patients with hepatitis C virus (HCV)... - Alcohol intake in prairie voles is influenced by the drinking level of a peerAllison M J Anacker
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
Alcohol Clin Exp Res 35:1884-90. 2011..Here, we investigated this correlated drinking behavior, hypothesizing that 1 animal alters its alcohol intake to match the drinking of its partner... - Administration of pegylated interferon-alpha-2a or -2b does not induce sickness behavior in Lewis ratsJennifer M Loftis
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, 3710 SW US Veteran s Hospital Road, Portland, OR 97239, USA
Psychoneuroendocrinology 31:1289-94. 2006..Collectively, our data suggest that Lewis rats are likely not a useful model to study IFN-induced depression... - Psychiatric and substance use disorders in individuals with hepatitis C: epidemiology and managementJennifer M Loftis
Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
Drugs 66:155-74. 2006.... - Association of interferon-alpha-induced depression and improved treatment response in patients with hepatitis CJennifer M Loftis
Portland VA Medical Center, Behavioral Health and Clinical Neurosciences Division, OR, USA
Neurosci Lett 365:87-91. 2004..In conclusion, our findings suggest that IFN-alpha-induced MDD may be a predictor of a positive response to IFN-alpha therapy, or an indication of optimal dosing... - Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders... - Prairie voles as a novel model of socially facilitated excessive drinkingAllison M J Anacker
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland Veterans Affairs Medical Center, 97238, USA
Addict Biol 16:92-107. 2011..The high ethanol preference and sensitivity to social manipulation indicate that prairie voles can serve to model social influences on excessive drinking... - Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunitJennifer M Loftis
Research Service, VA Medical Center, Portland, OR 97201, USA
Psychopharmacology (Berl) 164:349-59. 2002..Thus, NR1 phosphorylation could be important for the activation of pathways that are substrates for the effects of cocaine exposure and withdrawal... - Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophanErick H Turner
Mood Disorders Center, Portland VA Medical Center, Portland, OR 97239, USA
Pharmacol Ther 109:325-38. 2006..Safety issues with 5-HTP are also reviewed, with emphasis on eosinophilia myalgia syndrome (EMS) and serotonin syndrome... - Corticotropin releasing factor-1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1? administrationClare J Wilhelm
Research and Development Service, Portland VA Medical Center, 3710 SW U S Veterans Hospital Rd, Portland, OR 97239, USA
Neuropharmacology 62:313-21. 2012..Thus, additional studies will be needed to determine whether CRF(1) antagonism is an effective treatment for cytokine-induced sickness. This article is part of a Special Issue entitled 'Anxiety and Depression'... - Can rodents be used to model interferon-alpha-induced depressive symptoms?Jennifer M Loftis
Prog Neuropsychopharmacol Biol Psychiatry 30:1364-5; author reply 1366. 2006 - Hepatitis C treatment of veterans with psychiatric illnessMuhamad Aly Rifai
Am J Gastroenterol 101:673-4; author reply 674-5. 2006 - Interferon-alpha treatment of patients with Hepatitis C: the role of a comprehensive risk-benefit assessmentMuhamad Aly Rifai
CNS Drugs 19:719-21; author reply 721-2. 2005 - Comments on the paper 'The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C: a pilot study'Jennifer M Loftis
Hum Psychopharmacol 20:211-2; author reply 213. 2005 - Co-occurring Hepatitis C, substance use, and psychiatric illness: treatment issues and developing integrated models of careDiana L Sylvestre
Department of Medicine, University of California, San Francisco, California, USA
J Urban Health 81:719-34. 2004..This conference report summarizes current data, medical management issues, and strategies discussed... - Safety of the treatment of interferon-alpha-induced depressionJennifer M Loftis
Psychosomatics 44:524-6. 2003