P Kurre

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi Diagnosis and treatment of children with aplastic anemia
    Peter Kurre
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Pediatr Blood Cancer 45:770-80. 2005
  2. ncbi Rapid 1-hour transduction of whole bone marrow leads to long-term repopulation of murine recipients with lentivirus-modified hematopoietic stem cells
    P Kurre
    Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Gene Ther 13:369-73. 2006
  3. ncbi Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo
    Yung Wei Pan
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    J Virol 81:639-49. 2007
  4. ncbi Ex vivo selection for oncoretrovirally transduced green fluorescent protein-expressing CD34-enriched cells increases short-term engraftment of transduced cells in baboons
    Hans Peter Kiem
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Gene Ther 13:891-9. 2002
  5. ncbi Kinetics of fluorescence expression in nonhuman primates transplanted with GFP retrovirus-modified CD34 cells
    Peter Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington 98109, USA
    Mol Ther 6:83-90. 2002
  6. ncbi In vivo administration of interferon gamma does not cause marrow aplasia in mice with a targeted disruption of FANCC
    Peter Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Exp Hematol 30:1257-62. 2002
  7. ncbi Scaffold attachment region-containing retrovirus vectors improve long-term proviral expression after transplantation of GFP-modified CD34+ baboon repopulating cells
    Peter Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Blood 102:3117-9. 2003
  8. ncbi Efficient marking of murine long-term repopulating stem cells targeting unseparated marrow cells at low lentiviral vector particle concentration
    Peter Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Ther 9:914-22. 2004
  9. ncbi Multiarm high-throughput integration site detection: limitations of LAM-PCR technology and optimization for clonal analysis
    Michael A Harkey
    Department of Transplantation Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Stem Cells Dev 16:381-92. 2007
  10. ncbi Fanconi anemia type C-deficient hematopoietic cells are resistant to TRAIL (TNF-related apoptosis-inducing ligand)-induced cleavage of pro-caspase-8
    Uwe Platzbecker
    University Hospital Carl Gustav Carus, Dresden, Germany
    Exp Hematol 32:815-21. 2004

Research Grants

  1. HSC transduction in situ by cellular delivery of integrating viral vectors
    Peter Kurre; Fiscal Year: 2010
  2. Genetic targeting of proviral integration in stem cells
    Peter Kurre; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. ncbi Diagnosis and treatment of children with aplastic anemia
    Peter Kurre
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Pediatr Blood Cancer 45:770-80. 2005
    ..The challenge in making treatment recommendations for children with SAA, therefore, is to balance the apparent chronicity and morbidity following IST, with the potential up-front toxicity and complications of HSCT...
  2. ncbi Rapid 1-hour transduction of whole bone marrow leads to long-term repopulation of murine recipients with lentivirus-modified hematopoietic stem cells
    P Kurre
    Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Gene Ther 13:369-73. 2006
    ..Our results demonstrate the unique ability of HIV-derived vectors to transduce hematopoietic stem cells in the absence of enrichment, under minimal cytokine stimulation, and following brief exposures...
  3. ncbi Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo
    Yung Wei Pan
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    J Virol 81:639-49. 2007
    ..We demonstrate genetic marking by inadvertent transfer of vector particles and prolonged expression of transgene product in recipient tissues. Our findings have implications for biosafety, vector design, and cell biology research...
  4. ncbi Ex vivo selection for oncoretrovirally transduced green fluorescent protein-expressing CD34-enriched cells increases short-term engraftment of transduced cells in baboons
    Hans Peter Kiem
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Gene Ther 13:891-9. 2002
    ....
  5. ncbi Kinetics of fluorescence expression in nonhuman primates transplanted with GFP retrovirus-modified CD34 cells
    Peter Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington 98109, USA
    Mol Ther 6:83-90. 2002
    ..In comparison to mouse studies, however, we did not detect substantial differences between MND and MoMuLV backbones...
  6. ncbi In vivo administration of interferon gamma does not cause marrow aplasia in mice with a targeted disruption of FANCC
    Peter Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Exp Hematol 30:1257-62. 2002
    ..Additional selective pressure may be necessary to achieve targeted ablation of uncorrected, FA-phenotype, marrow cells...
  7. ncbi Scaffold attachment region-containing retrovirus vectors improve long-term proviral expression after transplantation of GFP-modified CD34+ baboon repopulating cells
    Peter Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Blood 102:3117-9. 2003
    ....
  8. ncbi Efficient marking of murine long-term repopulating stem cells targeting unseparated marrow cells at low lentiviral vector particle concentration
    Peter Kurre
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Ther 9:914-22. 2004
    ..Thus, gene transfer efficiencies may be limited when single-copy integration is desired and additional strategies such as in vivo selection may be required to improve the frequency of gene-modified cells...
  9. ncbi Multiarm high-throughput integration site detection: limitations of LAM-PCR technology and optimization for clonal analysis
    Michael A Harkey
    Department of Transplantation Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Stem Cells Dev 16:381-92. 2007
    ....
  10. ncbi Fanconi anemia type C-deficient hematopoietic cells are resistant to TRAIL (TNF-related apoptosis-inducing ligand)-induced cleavage of pro-caspase-8
    Uwe Platzbecker
    University Hospital Carl Gustav Carus, Dresden, Germany
    Exp Hematol 32:815-21. 2004
    ..These data provide further insight into the complexity of FA-C-regulated apoptotic signaling...
  11. ncbi CXCR4 induction in hematopoietic progenitor cells from Fanca(-/-), -c(-/-), and -d2(-/-) mice
    Amy M Skinner
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Exp Hematol 36:273-82. 2008
    ..However, inherent repopulation deficits and stem cell attrition during conventional transduction culture prevent therapeutic chimerism...

Research Grants5

  1. HSC transduction in situ by cellular delivery of integrating viral vectors
    Peter Kurre; Fiscal Year: 2010
    ....
  2. Genetic targeting of proviral integration in stem cells
    Peter Kurre; Fiscal Year: 2007
    ..The comprehensive training environment at Oregon Health & Science University (OHSU) and the substantial institutional commitment to my career will allow me to accomplish the goals of this proposal. ..