Jane X Kelly

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi Discovery of dual function acridones as a new antimalarial chemotype
    Jane X Kelly
    Portland Veterans Affairs Medical Centre, Portland, Oregon 97239, USA
    Nature 459:270-3. 2009
  2. ncbi Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum
    Jane X Kelly
    Medical Research Service, R and D 33, Portland Veterans Affairs Medical Center, Portland, OR 97239, USA
    Antimicrob Agents Chemother 51:4133-40. 2007
  3. ncbi Antimalarial quinolones: synthesis, potency, and mechanistic studies
    Rolf W Winter
    Biomedical Laboratory R and D Service, Mail Code RD 33, Experimental Chemotherapy Laboratory, VA Medical Center, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, USA
    Exp Parasitol 118:487-97. 2008
  4. ncbi Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds
    Steven J Burgess
    Department of Chemistry, Portland State University, PO Box 751, Portland, Oregon 97207 0751, USA
    J Med Chem 53:6477-89. 2010
  5. ncbi Optimization of endochin-like quinolones for antimalarial activity
    Rolf Winter
    Experimental Chemotherapy Laboratory, Mail Code RD 33, VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Exp Parasitol 127:545-51. 2011
  6. ncbi Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone
    Rozalia A Dodean
    Department of Chemistry, Portland State University, Portland, OR 97207, USA
    Bioorg Med Chem 16:1174-83. 2008
  7. ncbi Selective killing of the human malaria parasite Plasmodium falciparum by a benzylthiazolium dye
    Jane X Kelly
    Medical Research Service, RD 33, Department of Veterans Affairs Medical Center, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, and Department of Chemistry, Portland State University, Portland, OR 97207 0751, USA
    Exp Parasitol 116:103-10. 2007
  8. ncbi Evaluation and lead optimization of anti-malarial acridones
    Rolf W Winter
    Medical Research Service, RD-33, VA Medical Center, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239, USA
    Exp Parasitol 114:47-56. 2006

Collaborators

Detail Information

Publications8

  1. ncbi Discovery of dual function acridones as a new antimalarial chemotype
    Jane X Kelly
    Portland Veterans Affairs Medical Centre, Portland, Oregon 97239, USA
    Nature 459:270-3. 2009
    ..In summary, this innovative acridone design merges intrinsic potency and resistance-counteracting functions in one molecule, and represents a new strategy to expand, enhance and sustain effective antimalarial drug combinations...
  2. ncbi Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum
    Jane X Kelly
    Medical Research Service, R and D 33, Portland Veterans Affairs Medical Center, Portland, OR 97239, USA
    Antimicrob Agents Chemother 51:4133-40. 2007
    ..The combined results indicate that 10-N-substituted acridones present novel pharmacophores for the development of chemosensitizers against P. falciparum...
  3. ncbi Antimalarial quinolones: synthesis, potency, and mechanistic studies
    Rolf W Winter
    Biomedical Laboratory R and D Service, Mail Code RD 33, Experimental Chemotherapy Laboratory, VA Medical Center, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, USA
    Exp Parasitol 118:487-97. 2008
    ..Further studies of halogenated alkyl- and alkoxy-quinolones may lead to the development of safe and effective therapeutics for use in treatment or prevention of malaria and other parasitic diseases...
  4. ncbi Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds
    Steven J Burgess
    Department of Chemistry, Portland State University, PO Box 751, Portland, Oregon 97207 0751, USA
    J Med Chem 53:6477-89. 2010
    ..We also present evidence of the mode of action, indicating that the RCQ molecules inhibit hemozoin formation in the parasite's digestive vacuole in a manner similar to that of chloroquine...
  5. ncbi Optimization of endochin-like quinolones for antimalarial activity
    Rolf Winter
    Experimental Chemotherapy Laboratory, Mail Code RD 33, VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Exp Parasitol 127:545-51. 2011
    ..These findings provide compelling evidence that development of ELQ therapeutics is feasible...
  6. ncbi Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone
    Rozalia A Dodean
    Department of Chemistry, Portland State University, Portland, OR 97207, USA
    Bioorg Med Chem 16:1174-83. 2008
    ..For the first time, NMR studies for the heme-drug interactions are carried out at pH 5.0, physiological for the acidic food vacuole of the malaria parasite...
  7. ncbi Selective killing of the human malaria parasite Plasmodium falciparum by a benzylthiazolium dye
    Jane X Kelly
    Medical Research Service, RD 33, Department of Veterans Affairs Medical Center, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, and Department of Chemistry, Portland State University, Portland, OR 97207 0751, USA
    Exp Parasitol 116:103-10. 2007
    ....
  8. ncbi Evaluation and lead optimization of anti-malarial acridones
    Rolf W Winter
    Medical Research Service, RD-33, VA Medical Center, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239, USA
    Exp Parasitol 114:47-56. 2006
    ..Haloalkoxyacridones represent an extraordinarily potent novel class of chemical compounds with the potential for development as therapeutic agents to treat or prevent malaria in humans...