B Frei

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. ncbi On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction
    B Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Proc Soc Exp Biol Med 222:196-204. 1999
  2. ncbi Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E)
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Circ Res 87:349-54. 2000
  3. ncbi Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid
    J H Suh
    Linus Pauling Institute, Department of Biochemistry, Oregon State University, Corvallis, Oregon 97331, USA
    FASEB J 15:700-6. 2001
  4. ncbi Myeloperoxidase binds to low-density lipoprotein: potential implications for atherosclerosis
    A C Carr
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    FEBS Lett 487:176-80. 2000
  5. ncbi Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
    W J Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    FASEB J 15:2423-32. 2001
  6. ncbi Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein
    A C Carr
    Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331, USA
    Biochem J 346:491-9. 2000
  7. ncbi Comparison of low-density lipoprotein modification by myeloperoxidase-derived hypochlorous and hypobromous acids
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Free Radic Biol Med 31:62-72. 2001
  8. ncbi Relative reactivities of N-chloramines and hypochlorous acid with human plasma constituents
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 30:526-36. 2001
  9. ncbi The nitric oxide congener nitrite inhibits myeloperoxidase/H2O2/ Cl- -mediated modification of low density lipoprotein
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 276:1822-8. 2001
  10. ncbi Red wine antioxidants bind to human lipoproteins and protect them from metal ion-dependent and -independent oxidation
    V Ivanov
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331
    J Agric Food Chem 49:4442-9. 2001

Collaborators

Detail Information

Publications12

  1. ncbi On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction
    B Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Proc Soc Exp Biol Med 222:196-204. 1999
    ....
  2. ncbi Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E)
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Circ Res 87:349-54. 2000
    ..Therefore, an optimum vitamin C intake or body status may help protect against atherosclerosis and its clinical sequelae, whereas vitamin E may only be effective in combination with vitamin C...
  3. ncbi Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid
    J H Suh
    Linus Pauling Institute, Department of Biochemistry, Oregon State University, Corvallis, Oregon 97331, USA
    FASEB J 15:700-6. 2001
    ..Our data indicate that the aging rat heart is under increased mitochondrial-induced oxidative stress, which is significantly attenuated by lipoic acid supplementation...
  4. ncbi Myeloperoxidase binds to low-density lipoprotein: potential implications for atherosclerosis
    A C Carr
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    FEBS Lett 487:176-80. 2000
    ..Binding of MPO to LDL could potentially enhance site-directed oxidation of the lipoprotein and limit scavenging of reactive oxygen species by antioxidants...
  5. ncbi Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
    W J Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    FASEB J 15:2423-32. 2001
    ....
  6. ncbi Vitamin C protects against and reverses specific hypochlorous acid- and chloramine-dependent modifications of low-density lipoprotein
    A C Carr
    Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331, USA
    Biochem J 346:491-9. 2000
    ..As HOCl-mediated LDL modifications have been strongly implicated in the pathogenesis of atherosclerosis, our data indicate that vitamin C could contribute to the anti-atherogenic defence against HOCl...
  7. ncbi Comparison of low-density lipoprotein modification by myeloperoxidase-derived hypochlorous and hypobromous acids
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Free Radic Biol Med 31:62-72. 2001
    ..Our data show that even though HOBr has different reactivities than HOCl with apoB, it is able to alter the charge of LDL, converting it into a potentially atherogenic particle...
  8. ncbi Relative reactivities of N-chloramines and hypochlorous acid with human plasma constituents
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 30:526-36. 2001
    ..Together, our data indicate that in biological fluids N-chloramines react more readily with protein thiols than with methionine residues or ascorbate, and thus may cause biologically relevant, selective loss of thiol groups...
  9. ncbi The nitric oxide congener nitrite inhibits myeloperoxidase/H2O2/ Cl- -mediated modification of low density lipoprotein
    A C Carr
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 276:1822-8. 2001
    ..These data offer a novel mechanism for a potential antiatherogenic effect of the nitric oxide congener nitrite...
  10. ncbi Red wine antioxidants bind to human lipoproteins and protect them from metal ion-dependent and -independent oxidation
    V Ivanov
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331
    J Agric Food Chem 49:4442-9. 2001
    ..Our data indicate that red wine components bind to LDL and HDL and protect these lipoproteins from metal ion-dependent and -independent protein and lipid oxidation...
  11. ncbi Ldl modified by hypochlorous acid is a potent inhibitor of lecithin-cholesterol acyltransferase activity
    M R McCall
    Linus Pauling Institute, Oregon State University, Corvallis 97331-6512, USA
    Arterioscler Thromb Vasc Biol 21:1040-5. 2001
    ..Our data indicate that N-chloramines from HOCl-modified LDL mediate the loss of plasma LCAT activity and provide a novel mechanism by which myeloperoxidase-generated HOCl may promote atherogenesis...
  12. ncbi Lipoic acid significantly restores, in rats, the age-related decline in vasomotion
    A R Smith
    Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Br J Pharmacol 153:1615-22. 2008
    ..We hypothesized that ceramide accumulation was from an age-related loss of endothelial glutathione (GSH) and subsequent activation of neutral sphingomyelinase (nSMase), an enzyme whose activity increases when GSH is limited...