Research Topics
| T G DelougherySummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Detail Information
Publications
Anticoagulant therapy in special circumstancesT G Deloughery
Hematology OP 28, Oregon Health Sciences University, Portland, 97201 3098, USA
Curr Cardiol Rep 2:74-9. 2000....
Venous thrombotic emergenciesThomas G Deloughery
Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health and Science University, L586, Portland, OR 97201 3098, USA
Emerg Med Clin North Am 27:445-58. 2009..Rarer entities, such as cerebral vein thrombosis and Budd-Chiari syndrome, are also reviewed...
Estrogen and thrombosis: controversies and common senseThomas G Deloughery
Knight Cancer Center, Hematology Laboratory Medicine, Departments of Medicine, Pathology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97229 3098, USA
Rev Endocr Metab Disord 12:77-84. 2011..For women with bleeding disorders these prothrombotic changes can help decrease bleeding complications. There is now also abundant data on future management of patients with estrogen related thrombosis...
Practical aspects of the oral new anticoagulantsThomas G Deloughery
Division of Hematology Medical Oncology, Department of Medicine, Oregon Health Sciences University, Portland, 97201 3098, USA
Am J Hematol 86:586-90. 2011..Also to be discussed are practical aspects of use of these new agents such monitoring, reversal, and use before procedures...
Critical care clotting catastrophiesThomas G Deloughery
Oregon Health and Science University, Hematology L586, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
Crit Care Clin 21:531-62. 2005..These include heparin induced thrombocytopenia, thrombotic thrombocytopenic purpura, and disseminated intravascular coagulation...
Management of bleeding emergencies: when to use recombinant activated factor VIIThomas G Deloughery
Division of Hematology Medical Oncology, Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
Expert Opin Pharmacother 7:25-34. 2006..Although most of the reports on rVIIa are anecdotes and case series, there is increasing data for clinical trials to help guide usage...
Update in hematologyThomas G Deloughery
Divisions of Hematology/Medical Oncology, Oregon Health and Science University, Portland, Oregon 97239-3098, USA
Ann Intern Med 147:717-24. 2007
Management of acquired bleeding problems in cancer patientsThomas G Deloughery
Division of Hematology, Department of Medicine, L586, Oregon Health and Science University, Portland, OR 97201 3098, USA
Emerg Med Clin North Am 27:423-44. 2009..Specific issue including coagulation defects, thrombocytopenia, platelet dysfunction, bleeding complications of specific hematological malignancies and due to anticoagulation, are discussed...
Thrombocytopenia and other hot topicsThomas G Deloughery
Oregon Health Sciences University, Portland, 97239 3098, USA
Am J Clin Oncol 32:S13-7. 2009..Given the ongoing clinical questions and new drugs, anticoagulant therapy in patients with cancer promises to have an exciting future...
Venous thrombotic emergenciesThomas G Deloughery
Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health and Science University, L586, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
Hematol Oncol Clin North Am 24:487-500. 2010..Rarer entities, such as cerebral vein thrombosis and Budd-Chiari syndrome, are also reviewed...
Management of acquired bleeding problems in cancer patientsThomas G Deloughery
Divisions of Hematology and Medical Oncology, Department of Medicine, L586, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
Hematol Oncol Clin North Am 24:603-24. 2010..Specific issues including coagulation defects, thrombocytopenia, platelet dysfunction, and bleeding complications of specific hematological malignancies due to anticoagulation, are discussed...
Logistics of massive transfusionsThomas G Deloughery
Division of Hematology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
Hematology Am Soc Hematol Educ Program 2010:470-3. 2010..The proper management of massive transfusions-whether they are in trauma patients or other bleeding patients-requires coordination of the personnel in the surgical suite or the emergency department, the blood bank, and laboratory...
Venous thromboembolism in the ICU and reversal of bleeding on anticoagulantsThomas G Deloughery
Oregon Health and Science University, Hematology L586, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
Crit Care Clin 21:497-512. 2005..The increased use of antithrombotic agents has led to an increased number of patients who experience bleeding complications on anticoagulant therapy. This review also addresses the methods of reversing various anticoagulants...
Coagulation abnormalities and cardiovascular diseaseT G Deloughery
Department of Medicine, Oregon Health Sciences University, Portland 97201 3098, USA
Curr Opin Lipidol 10:443-8. 1999..Pathogenic polymorphisms in the platelet fibrinogen and collagen receptors remains an area of intense research interest. Finally, it has been shown that lipoproteins can act as mediators of coagulation processes...
Moderate hypoxia suppresses exercise-induced procoagulant changesThomas G Deloughery
Division of Hematology Medical Oncology, Department of Medicine, Oregan Health and Science Univerity, Portland, OR 97239 3098, USA
Br J Haematol 125:369-72. 2004..Thus, it appears that hypoxia may exert an antithrombotic effect by both damping exercise-induced procoagulant changes and stimulating fibrinolysis...
Coagulation defects in trauma patients: etiology, recognition, and therapyThomas G Deloughery
Division of Medical Oncology, L586 Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
Crit Care Clin 20:13-24. 2004..Attention also should be paid to any other correctable factors such as hypothermia. Finally, pre-existing disorders can influence the patient's hemostasis greatly and may require specific therapies...
Management of bleeding with uremia and liver diseaseT G Deloughery
Hematology OP 28, Oregon Health Sciences University, Portland 97201 3098, USA
Curr Opin Hematol 6:329-33. 1999..Careful assessment of both the patient's clinical situation and laboratory findings is important for tailoring therapy of the bleeding patient...
Pulmonary hemorrhage in a hemophiliac simulating a lung neoplasmM E O'Dwyer
Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, Oregon 97201, USA
Am J Hematol 64:299-302. 2000..This is the first report of symptomatic pulmonary hemorrhage in a patient with hemophilia B. Hemorrhage into a pre-existing bulla can simulate a primary lung neoplasm...
Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat modelE A Neuwelt
Department of Neurology, Oregon Health Sciences University, Portland, Oregon 97201, USA
Cancer Res 61:7868-74. 2001....
First episode and recurrent venous thromboembolism: who is identifiably at risk?Timothy K Liem
Division of Vascular Surgery, Oregon Health and Science University, OP 11, 3181 SW Sam Jackson Park Road, Portland, OR, USA
Semin Vasc Surg 21:132-8. 2008....
Coagulation management in massive bleedingMatthew J Griffee
Department of Anesthesiology and Perioperative Medicine, USA
Curr Opin Anaesthesiol 23:263-8. 2010..To update readers on recent literature regarding treatment of coagulopathy for patients with life-threatening bleeding, highlighting emerging therapeutic options, controversial topics, and ongoing clinical trials...
Pulmonary and intracerebral plasmacytomas in a patient without multiple myeloma: a case reportBrandon Hayes-Lattin
Division of Hematology and Medical Oncology, Oregon Health and Science University, The OHSU Cancer Institute, Portland, Oregon 97202, USA
Am J Hematol 73:131-4. 2003..Extramedullary plasmacytoma of the lung or brain parenchyma is rare. We report herein a case of extramedullary plasmacytoma involving both the lung and parenchymal brain. We review the literature, comparing and contrasting the current case...
Safety of inferior vena cava filter retrieval in anticoagulated patientsHanno Hoppe
Dotter Interventional Institute, Oregon Health and Science University, L 605, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 3098, USA
Chest 132:31-6. 2007....
High dose calcitriol may reduce thrombosis in cancer patientsTomasz M Beer
Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR 97239, USA
Br J Haematol 135:392-4. 2006..In vitro and vitamin D receptor (VDR) knockout mouse studies predict that nanomolar concentrations of calcitriol may act as an antithrombotic agent. We report the first clinical observation that supports this hypothesis in humans...
Acute bilateral pulmonary emboli occurring while on adjuvant aromatase inhibitor therapy with anastrozole: Case report and review of the literatureJennifer L Lycette
Division of Hematology and Medical Oncology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Mailcode L586, Portland, OR 97239, USA
Breast Cancer Res Treat 99:249-55. 2006....
A phase I study of 5-fluorouracil, leucovorin, and celecoxib in patients with incurable colorectal cancerCharles D Blanke
Oregon Health and Science University Cancer Institute, Portland, OR, USA
Prostaglandins Other Lipid Mediat 75:169-72. 2005..5-FU and leucovorin did not affect COX-2 inhibition by celecoxib. Preliminary data suggest it is safe to combine celecoxib with standard chemotherapeutic agents, in treatment of patients with colorectal cancer...
Symptomatic perioperative venous thromboembolism is a frequent complication in patients with a history of deep vein thrombosisTimothy K Liem
Division of Vascular Surgery and the Division of Hematology Oncology, Oregon Health and Science University, Portland, Ore 97239, USA
J Vasc Surg 52:651-7. 2010..This study determined the incidence and risk factors for symptomatic perioperative VTE in patients with a prior diagnosis of DVT...
Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiencyR Chou
Department of Medicine, Portland Veteran s Affairs Medical Center, Oregon Health Sciences University, Portland, Oregon, USA
Am J Hematol 67:197-9. 2001....
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular diseaseT G Deloughery
Department of Medicine, Oregon Health Sciences University, Portland 97201 3098, USA
Circulation 94:3074-8. 1996..We determined the prevalence of this mutation in many subjects with and without vascular disease and related it to homocysteine and folate levels...
The prognostic value of hemoglobin change after initiating androgen-deprivation therapy for newly diagnosed metastatic prostate cancer: A multivariate analysis of Southwest Oncology Group Study 8894Tomasz M Beer
Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, Oregon, USA
Cancer 107:489-96. 2006..Although race alone was not a strong predictor of death or disease progression, the effect of the baseline HGB level on overall and progression-free survival varied significantly by race...
Evolutionary conservation of the AU-rich 3' untranslated region of messenger RNAM A Asson-Batres
Department of Medicine, Oregon Health Sciences University, Portland 97201
Proc Natl Acad Sci U S A 91:1318-22. 1994....
Phase II study of transdermal estradiol in androgen-independent prostate carcinomaLisa B Bland
Division of Urology, Oregon Health and Science University and Portland Veterans Affairs Medical Center, Portland, Oregon, 97239, USA
Cancer 103:717-23. 2005..CONCLUSIONS: In patients with APIC, TDE was well tolerated and produced a modest response rate, but was not associated with thromboembolic complications or clinically important changes in several coagulation factors...
Effects of Ginkgo biloba on exhaled nasal nitric oxide during normobaric hypoxia in humansCasey Jowers
Oregon Health and Sciences University, Portland, OR, USA
High Alt Med Biol 5:445-9. 2004..Our results suggest that Ginkgo biloba may act to reduce AMS through an effect on NO metabolism...
