Julia L Cook

Summary

Affiliation: Ochsner Clinic Foundation
Country: USA

Publications

  1. ncbi Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model
    Julia L Cook
    Laboratory of Molecular Genetics, Department of Research, New Orleans, LA 70121, USA
    Am J Physiol Regul Integr Comp Physiol 302:R482-93. 2012
  2. ncbi The trafficking protein GABARAP binds to and enhances plasma membrane expression and function of the angiotensin II type 1 receptor
    Julia L Cook
    Division of Research, Ochsner Clinic Foundation, Ochsner Health System, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
    Circ Res 102:1539-47. 2008
  3. ncbi Cleavage of the angiotensin II type 1 receptor and nuclear accumulation of the cytoplasmic carboxy-terminal fragment
    Julia L Cook
    Ochsner Clinic Foundation, Ochsner Health System, 1516 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Cell Physiol 292:C1313-22. 2007
  4. ncbi Expression of a naturally occurring angiotensin AT(1) receptor cleavage fragment elicits caspase-activation and apoptosis
    Julia L Cook
    Laboratory of Molecular Genetics, Department of Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Cell Physiol 301:C1175-85. 2011
  5. ncbi Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation
    Julia L Cook
    Ochsner Clinic Foundation, Division of Research, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 40:696-707. 2006
  6. ncbi Intracellular angiotensin II fusion protein alters AT1 receptor fusion protein distribution and activates CREB
    Julia L Cook
    Division of Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 36:75-90. 2004
  7. ncbi Temporal changes in gene expression following cryogenic rat brain injury
    J L Cook
    Ochsner Medical Foundation, Division of Research, New Orleans, LA, USA
    Brain Res Mol Brain Res 55:9-19. 1998
  8. ncbi Intracellular angiotensin II increases the long isoform of PDGF mRNA in rat hepatoma cells
    Julia L Cook
    Division of Research, Ochsner Clinic Foundation, 1516 Jefferson Hwy, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 34:1525-37. 2002
  9. ncbi In vitro evidence for an intracellular site of angiotensin action
    J L Cook
    Division of Research, Ochsner Clinic Foundation, New Orleans, LA, USA
    Circ Res 89:1138-46. 2001
  10. ncbi Simultaneous analysis of multiple gene expression patterns as a function of development, injury or senescence
    J L Cook
    Ochsner Medical Foundation, Division of Research, New Orleans, LA, USA
    Brain Res Brain Res Protoc 3:1-6. 1998

Research Grants

  1. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009

Collaborators

Detail Information

Publications28

  1. ncbi Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model
    Julia L Cook
    Laboratory of Molecular Genetics, Department of Research, New Orleans, LA 70121, USA
    Am J Physiol Regul Integr Comp Physiol 302:R482-93. 2012
    ..Appreciation of the diverse, pleiotropic intracellular effects of components of the renin-angiotensin system should lead to alternative disease treatment targets and new therapies...
  2. ncbi The trafficking protein GABARAP binds to and enhances plasma membrane expression and function of the angiotensin II type 1 receptor
    Julia L Cook
    Division of Research, Ochsner Clinic Foundation, Ochsner Health System, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
    Circ Res 102:1539-47. 2008
    ..Immunoblot analyses confirmed the quantitative image data. We conclude that GABARAP binds to and promotes trafficking of the AT(1)R to the plasma membrane...
  3. ncbi Cleavage of the angiotensin II type 1 receptor and nuclear accumulation of the cytoplasmic carboxy-terminal fragment
    Julia L Cook
    Ochsner Clinic Foundation, Ochsner Health System, 1516 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Cell Physiol 292:C1313-22. 2007
    ..Overexpressed native AT(1)R (nonfusion) is also cleaved; the intracellular 6-kDa cytoplasmic domain product accumulates to a significantly higher level with ANG II treatment...
  4. ncbi Expression of a naturally occurring angiotensin AT(1) receptor cleavage fragment elicits caspase-activation and apoptosis
    Julia L Cook
    Laboratory of Molecular Genetics, Department of Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Cell Physiol 301:C1175-85. 2011
    ..CF-induced apoptosis, therefore, appears to be a general phenomenon as it is observed in multiple cell types including smooth muscle cells and cardiomyoblasts...
  5. ncbi Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation
    Julia L Cook
    Ochsner Clinic Foundation, Division of Research, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 40:696-707. 2006
    ..Extracellular AII also stimulates a unique pathway, apparently reflecting interaction with plasma membrane-associated AT(1)R...
  6. ncbi Intracellular angiotensin II fusion protein alters AT1 receptor fusion protein distribution and activates CREB
    Julia L Cook
    Division of Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 36:75-90. 2004
    ..Exogenous AII similarly significantly increases CREB activation in AT1R/EYFP-stably transfected CHO-K1 and COS-7 cells...
  7. ncbi Temporal changes in gene expression following cryogenic rat brain injury
    J L Cook
    Ochsner Medical Foundation, Division of Research, New Orleans, LA, USA
    Brain Res Mol Brain Res 55:9-19. 1998
    ..In the present model, many genes demonstrate elevated RNA levels in the cortex prior to hippocampus, following injury. RNAs transcribed from late genes tend to be elevated concurrently in cortex and hippocampus...
  8. ncbi Intracellular angiotensin II increases the long isoform of PDGF mRNA in rat hepatoma cells
    Julia L Cook
    Division of Research, Ochsner Clinic Foundation, 1516 Jefferson Hwy, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 34:1525-37. 2002
    ....
  9. ncbi In vitro evidence for an intracellular site of angiotensin action
    J L Cook
    Division of Research, Ochsner Clinic Foundation, New Orleans, LA, USA
    Circ Res 89:1138-46. 2001
    ....
  10. ncbi Simultaneous analysis of multiple gene expression patterns as a function of development, injury or senescence
    J L Cook
    Ochsner Medical Foundation, Division of Research, New Orleans, LA, USA
    Brain Res Brain Res Protoc 3:1-6. 1998
    ..All demonstrate increased expression following injury. Renin and c-fos exhibit detectable changes as early as 1 h post-injury...
  11. ncbi C-terminal processing of GABARAP is not required for trafficking of the angiotensin II type 1A receptor
    Jawed Alam
    Laboratory of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Regul Pept 159:78-86. 2010
    ....
  12. ncbi Noncanonical intracrine action
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA, USA
    J Am Soc Hypertens 5:435-48. 2011
    ..Moreover, an appreciation of noncanonical intracrine functionality informs our understanding of the major effector protein of the renin-angiotensin system, angiotensin II, as well as other hormones operative in cardiovascular biology...
  13. ncbi Mechanisms of disease: Intracrine physiology in the cardiovascular system
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 4:549-57. 2007
    ....
  14. ncbi The physiological basis of intracrine stem cell regulation
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 295:H447-53. 2008
    ..The reprogramming of cells to restore the pleuripotent phenotype and the possible role of stem/progenitor cells in neoplasia are also discussed...
  15. ncbi Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 297:H893-901. 2009
    ..These notions have potentially important therapeutic implications, including implications for the therapy of cardiovascular disease...
  16. ncbi Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, Louisiana State University Medical Center, New Orleans, Louisiana 70121, USA
    J Biol Chem 274:26071-8. 1999
    ..Taken together, these results implicate Nrf2 in the induction of the HO-1 gene but suggest that the Nrf2 partner in this function is a factor other than p18 or Jun proteins...
  17. ncbi Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway
    J Alam
    Department of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Curr Pharm Des 9:2499-511. 2003
    ..In principle, the multiplicity of StRE binding proteins also provides for a range of pharmaceutical targets for controlled production of the potentially therapeutic HO-1 protein...
  18. ncbi The basis of an intracrine pharmacology
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Clin Pharmacol 48:344-50. 2008
    ..The intracrine pharmacology of the renin-angiotensin system, angiogenesis, and stem cell development is discussed...
  19. ncbi The mitochondrial component of intracrine action
    Richard N Re
    Ochsner Clinic Foundation, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 299:H577-83. 2010
    ..The implications of this mitochondrial intracrine biology are discussed...
  20. ncbi How many transcription factors does it take to turn on the heme oxygenase-1 gene?
    Jawed Alam
    Department of Molecular Genetics, Ochsner Medical Center, New Orleans, LA 70121, USA
    Am J Respir Cell Mol Biol 36:166-74. 2007
    ..In this article we provide a review and analysis of the data supporting this proposition...
  21. ncbi Cell-penetrating peptides corresponding to the angiotensin II Type 1 receptor reduce receptor accumulation and cell surface expression and signaling
    Jason R Vitko
    Department of Molecular Genetics, Ochsner Clinic Foundation New Orleans, Los Angeles, USA
    Am J Hypertens 25:24-8. 2012
    ..This competitive binding study was designed as a first step toward evaluating the GABARAP:AT(1)R binding interface as a target for reducing AT(1)R trafficking to the plasma membrane...
  22. ncbi Inhibition of Erythroleukemia Cell Growth by Triplex-forming RNAs
    Richard N Re
    Department of Research, Ochsner Clinic Foundation, New Orleans, LA
    Ochsner J 7:58-60. 2007
    ..Conclusion: Triple helix-forming RNAs directed to a p53 consensus sequence homology reduce leukemia cell proliferation, suggesting a novel method of treatment...
  23. ncbi Potential therapeutic implications of intracrine angiogenesis
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, United States
    Med Hypotheses 69:414-21. 2007
    ..Here the participation and regulation of intracrines in angiogenesis is explored, as are the actions of various anti-angiogenic factors...
  24. ncbi The intracrine hypothesis: an update
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Regul Pept 133:1-9. 2006
    ..Here the intracrine hypothesis is briefly described and then recent experimental findings which bear on predictions made earlier on the basis of the theory are discussed. These findings provide new support for the intracrine hypothesis...
  25. ncbi An intracrine view of angiogenesis
    Richard N Re
    Research Division, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Bioessays 28:943-53. 2006
    ..Collectively, these explorations lead to testable hypotheses regarding the regulation of normal and pathological angiogenesis, and point to similarities between tumor-induced angiogenesis and tissue differentiation...
  26. ncbi The inhibition of tumor growth by triplex-forming oligonucleotides
    Richard N Re
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Cancer Lett 209:51-3. 2004
    ..05). A triplex forming oligonucleotide directed at a p53 consensus binding site reduces tumor growth suggesting a novel method of tumor inhibition...
  27. ncbi Suppression of cellular proliferation using p53 DNA recognition site-related oligonucleotides
    R N Re
    Alton Ochsner Medical Foundation, Division of Research, New Orleans, Louisiana, USA
    Am J Med Sci 311:65-72. 1996
    ..On the basis of these studies, p53 analogues may be used therapeutically to selectively modify proliferation of transformed cells...
  28. ncbi Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure
    K M Redding
    Department of Molecular Genetics, Ochsner Clinic Foundation, 1514 Jefferson Highway, Biomedical Research Bldg, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 298:H1807-18. 2010
    ..This transgenic model may be useful to further explore the intracellular renin-angiotensin system and its implication in abnormal kidney function and hypertension...

Research Grants6

  1. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..abstract_text> ..