Elissa J Chesler

Summary

Affiliation: Oak Ridge National Laboratory
Country: USA

Publications

  1. ncbi The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
    Elissa J Chesler
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Bldg 1059 MS 6420, P O Box 2008, Oak Ridge, TN 37831 6420, USA
    Mamm Genome 19:382-9. 2008
  2. ncbi Genetic analysis in the Collaborative Cross breeding population
    Vivek M Philip
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Genome Res 21:1223-38. 2011
  3. ncbi Extracting gene networks for low-dose radiation using graph theoretical algorithms
    Brynn H Voy
    Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
    PLoS Comput Biol 2:e89. 2006
  4. ncbi Inferring gene transcriptional modulatory relations: a genetical genomics approach
    Hongqiang Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 14:1119-25. 2005
  5. ncbi Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 3:e1977. 2008
  6. ncbi An informatics approach to systems neurogenetics
    Glenn D Rosen
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 401:287-303. 2007
  7. ncbi Genome-level analysis of genetic regulation of liver gene expression networks
    Daniel Gatti
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Hepatology 46:548-57. 2007
  8. ncbi Genetic networks controlling retinal injury
    Felix R Vazquez-Chona
    Department of Ophthalmology, The Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Vis 11:958-70. 2005
  9. ncbi Complex genetics of interactions of alcohol and CNS function and behavior
    Douglas B Matthews
    Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
    Alcohol Clin Exp Res 29:1706-19. 2005
  10. ncbi Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene
    Jeffrey S Mogil
    Department of Psychology and Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 1B1
    Proc Natl Acad Sci U S A 102:12938-43. 2005

Research Grants

  1. Ontological Discovery for Ethanol Research
    Elissa Chesler; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. ncbi The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
    Elissa J Chesler
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Bldg 1059 MS 6420, P O Box 2008, Oak Ridge, TN 37831 6420, USA
    Mamm Genome 19:382-9. 2008
    ..Herein we present a progress report of the Collaborative Cross breeding program at ORNL and a description of the kinds of investigations that this resource will support...
  2. ncbi Genetic analysis in the Collaborative Cross breeding population
    Vivek M Philip
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Genome Res 21:1223-38. 2011
    ..Despite these inescapable pressures, high diversity and precision for genetic mapping remain. These results demonstrate the potential of the CC population once completed and highlight implications for development of related populations...
  3. ncbi Extracting gene networks for low-dose radiation using graph theoretical algorithms
    Brynn H Voy
    Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
    PLoS Comput Biol 2:e89. 2006
    ..We present several examples of multiple gene interactions that are altered by radiation exposure and thus represent potential molecular pathways that mediate the radiation response...
  4. ncbi Inferring gene transcriptional modulatory relations: a genetical genomics approach
    Hongqiang Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 14:1119-25. 2005
    ..SNPs that distinguish between the two progenitor strains were used to further winnow the list of candidate modulators. Bayesian network was then used to identify the genetic modulatory relations that best explain the microarray data...
  5. ncbi Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 3:e1977. 2008
    ..The critical problem with naïve mapping approaches in AIL populations is that the individual is not an exchangeable unit...
  6. ncbi An informatics approach to systems neurogenetics
    Glenn D Rosen
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 401:287-303. 2007
    ..Taken together, these tools enable the user to begin to assess complex interactions of gene networks, and facilitate analysis of traits using a systems approach...
  7. ncbi Genome-level analysis of genetic regulation of liver gene expression networks
    Daniel Gatti
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Hepatology 46:548-57. 2007
    ..genenetwork.org) that allows custom data mining, identification of coregulated transcripts and correlated phenotypes, cross-tissue, and cross-species comparisons, as well as testing of a broad array of hypotheses...
  8. ncbi Genetic networks controlling retinal injury
    Felix R Vazquez-Chona
    Department of Ophthalmology, The Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Vis 11:958-70. 2005
    ..The present study defines genomic loci underlying coordinate changes in gene expression following retinal injury...
  9. ncbi Complex genetics of interactions of alcohol and CNS function and behavior
    Douglas B Matthews
    Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
    Alcohol Clin Exp Res 29:1706-19. 2005
    ..J. Hitzemann, and (5) The use of gene arrays in conjunction with transgenic and selected animals to understand anxiety in alcoholism, by. B. Tabakoff...
  10. ncbi Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene
    Jeffrey S Mogil
    Department of Psychology and Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 1B1
    Proc Natl Acad Sci U S A 102:12938-43. 2005
    ..Linkage mapping supports the contention that the genetic variant determining variable heat pain sensitivity across mouse strains affects the expression of the Calca gene that codes for CGRPalpha...
  11. ncbi Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    Elissa J Chesler
    University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    Nat Genet 37:233-42. 2005
    ..We built these tools into an open web resource called WebQTL that can be used to test a broad array of hypotheses...
  12. ncbi Brain gene expression: genomics and genetics
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Int Rev Neurobiol 60:59-95. 2004
  13. ncbi WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    Nat Neurosci 7:485-6. 2004
  14. ncbi Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, USA
    Neuroinformatics 1:343-57. 2003
    ..By repeatedly studying the same panel of mice, early data can be re-examined in light of technological advances unforeseen at the time of their initial collection...
  15. ncbi Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive
    Elissa J Chesler
    Department of Psychology, University of Illinois at Urbana-Champaign, 61820, USA
    Neurosci Biobehav Rev 26:907-23. 2002
    ....

Research Grants2

  1. Ontological Discovery for Ethanol Research
    Elissa Chesler; Fiscal Year: 2007
    ..This development work will occur in the context of a team of expert colleagues who will be capable of testing software, sharing data, performing biological interpretation and validating results of our analyses. ..