Research Topics
| Peter F WhitingtonSummaryAffiliation: Northwestern University Country: USA Publications
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Publications
Expression of osteopontin correlates with portal biliary proliferation and fibrosis in biliary atresiaPeter F Whitington
Department of Pediatrics, Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
Pediatr Res 57:837-44. 2005..These findings suggest a role for OPN in the pathogenesis of biliary atresia...- Neonatal hemochromatosis: is it an alloimmune disease?Peter F Whitington
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
J Pediatr Gastroenterol Nutr 40:544-9. 2005 - High-dose immunoglobulin during pregnancy for recurrent neonatal haemochromatosisPeter F Whitington
Department of Pediatrics, Feinberg School of Medicine of Northwestern University, 2300 Children s Plaza Box 57, Children s Memorial Hospital, Chicago, IL 60614, USA
Lancet 364:1690-8. 2004.... - Gestational alloimmune liver disease in cases of fetal deathPeter F Whitington
Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
J Pediatr 159:612-6. 2011..To determine whether alloimmune liver disease can be identified as a cause of fetal death... - Neonatal hemochromatosis: fetal liver disease leading to liver failure in the fetus and newbornPeter F Whitington
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Children s Memorial Hospital, The Siragusa Transplantation Center, Chicago, IL 60614, USA
Pediatr Transplant 9:640-5. 2005..Almost nothing is known about fetal onset liver failure, and there is no literature addressing the subject. This review will address fetal liver disease that leads to liver failure in the fetus or newborn... - Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient dietSean W P Koppe
Department of Medicine, Division of Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Hepatol 41:592-8. 2004..CONCLUSIONS: PTX decreases serum ALT levels and hepatic inflammation in the MCD model of steatohepatitis, likely via increasing glutathione levels or reducing TNF-alpha expression... - Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontinAtul Sahai
Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
Am J Physiol Gastrointest Liver Physiol 287:G1035-43. 2004..In conclusion, our results demonstrate the development of an obese/diabetic experimental model for NASH in db/db mice and suggest an important role for Ob-Ra and OPN in the pathogenesis of NASH... - Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico-left portal vein bypassTimothy B Lautz
Department of Surgery, Children s Memorial Hospital, Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA
J Pediatr Surg 44:2067-70. 2009..We hypothesized that growth parameters improve after reversal of portal hypertension and restoration of mesenteric venous blood flow to the liver by the mesenterico-left portal vein bypass (MLPVB)... - Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient mediumAtul Sahai
Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children's Memorial Research Center, Chicago, IL 60614, USA
Am J Physiol Gastrointest Liver Physiol 291:G55-62. 2006..PI3-kinase plays a central role in signaling the MCD medium-induced steatosis and increased OPN expression, whereas OPN appears to play a role in signaling hepatocyte ALT release but not steatosis... - Bile composition in Alagille Syndrome and PFIC patients having Partial External Biliary DiversionKaran M Emerick
Children s Memorial Hospital, Chicago, IL, USA
BMC Gastroenterol 8:47. 2008..PEBD can reduce disease progression, and examining the alterations in biliary lipid composition may be a prognostic factor for outcome... - Novel mechanism of fetal hepatocyte injury in congenital alloimmune hepatitis involves the terminal complement cascadeXiaomin Pan
Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Hepatology 51:2061-8. 2010..MAC-mediated alloimmune injury in congenital alloimmune hepatitis is a novel mechanism of liver injury that results from an interplay of maternal adaptive immunity and fetal innate immunity... - Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathwayRohit Kohli
Department of Pediatrics, Children s Memorial Hospital, Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
J Biol Chem 282:21327-36. 2007..Our findings suggest a common path for response to altered nutrition involving mitochondrial ROS-dependent PI 3-kinase pathway regulation, leading to steatosis... - Graft histology characteristics in long-term survivors of pediatric liver transplantationUdeme D Ekong
Department of Pediatrics, Children s Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
Liver Transpl 14:1582-7. 2008..The cause of this fibrosis is uncertain, and normal alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase levels do not exclude the presence of significant fibrosis... - Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine modelAtul Sahai
Department of Pediatrics, Children s Memorial Institute for Education and Research, Northwestern University, 2300 Children s Plaza, Box 212, Chicago, IL 60614, USA
Am J Physiol Gastrointest Liver Physiol 287:G264-73. 2004..In conclusion, our results demonstrate an upregulation of OPN expression early in the development of steatohepatitis and suggest an important role for OPN in signaling the onset of liver injury and fibrosis in experimental NASH... - Regional variation and use of exception letters for cadaveric liver allocation in children with chronic liver diseasePaolo R Salvalaggio
Department of Surgery, The Siragusa Transplantation Center, Children's Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago 60614, IL, USA
Am J Transplant 5:1868-74. 2005..Regional variation suggests that PELD has not resulted in standardization of listing practices in pediatric liver transplantation... - Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive abilityCara L Mack
Pediatrics, Northwestern University Feinberg School of Medicine, Children's Memorial Hospital, Chicago, Illinois, USA
Pediatrics 117:e405-12. 2006..MLPVB should be considered in treating primary EHPVT, because it corrects portal blood flow and could optimize learning potential... - Correction of extrahepatic portal vein thrombosis by the mesenteric to left portal vein bypassRiccardo Superina
Department of Surgery, Children s Memorial Hospital, Feinberg School of Medicine of North Western University, Chicago, IL 60614, USA
Ann Surg 243:515-21. 2006..The treatment of idiopathic EHPVT has been primarily palliative, whereas MLPVB restores hepatic portal flow in patients with EHPVT... - Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient dietShikha S Sundaram
Division of Gastroenterology and Hepatology and Nutrition, Departments of Pediatrics, Department of Internal Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
Am J Physiol Gastrointest Liver Physiol 288:G1321-7. 2005..They also have enhanced TNF-alpha, IL-6, and cytochrome P-450 2E1 expression. We conclude that TTR-Abcb11 mice develop a more rapid hepatitis with less steatosis... - Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver diseaseMiriam B Vos
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
J Pediatr Gastroenterol Nutr 47:481-5. 2008..Cytokeratin 18 (CK18) is an intracellular protein released into the blood by both necrosis and apoptosis of hepatocytes. Levels of CK18 have not been reported previously in children with NAFLD... - Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulinElizabeth B Rand
Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
J Pediatr 155:566-71. 2009.... - Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitisRui Liu
Department of Pediatrics, Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
Liver Int 29:337-43. 2009..Aim: We sought to understand the mechanisms by which serum ALT is elevated in a mouse model of experimental fatty liver disease where hepatocyte death is minimal... - Relationship of proximal renal tubular dysgenesis and fetal liver injury in neonatal hemochromatosisSilvana F Bonilla
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Pediatr Res 67:188-93. 2010..Hepatic synthetic failure resulting in insufficient production of AGT to support renal tubular development is the likely mechanism of kidney disease in NH... - Recombinant factor VIIa improves coagulopathy caused by liver failureJeffrey B Brown
Department of Gastroenterology, Hepatology, and Nutrition, Children's Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
J Pediatr Gastroenterol Nutr 37:268-72. 2003..Therapy subjectively reduces clinical bleeding and can improve fluid balance, without complications... - Survival after liver transplantation for hepatoblastoma: a 2-center experienceMarybeth Browne
Department of Surgery, Children s Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
J Pediatr Surg 43:1973-81. 2008..Complete resection with adjuvant chemotherapy is the accepted treatment for hepatoblastoma. The aim of this study is to evaluate our results of liver transplantation (LT) for tumors still unresectable after adequate chemotherapy... - Presence of multiple bile ducts in the liver graft increases the incidence of biliary complications in pediatric liver transplantationPaolo R O Salvalaggio
Department of Surgery, Children's Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
Liver Transpl 11:161-6. 2005..In conclusion, the presence of more than one bile duct in the graft is an independent risk factor for the development of biliary complications after pediatric liver transplantation... - Simultaneous surgical and interventional radiological approach to treat complicated biliary strictures after pediatric liver transplantationPaolo R O Salvalaggio
Department of Surgery, Children's Memorial Hospital, Northwestern University Feinberg School of Medicine, 700 W. Fullerton Street, Chicago, IL 60614, USA
Pediatr Transplant 8:513-6. 2004..We conclude that an aggressive combined surgical and radiologic approach can avoid retransplantation in patients with complicated post-transplant biliary strictures... - Regression of severe fibrotic liver disease in 2 children with neonatal hemochromatosisUdeme D Ekong
Departments of Pediatrics, Children's Memorial Hospital, Northwestern University, Chicago, IL 60614, USA
J Pediatr Gastroenterol Nutr 46:329-33. 2008 - Neonatal liver diseaseKaran McBride Emerick
Division of Gastroenterology, Hepatology, and Nutrition, Children s Memorial Hospital, Northwestern University School of Medicine, Chicago, IL, USA
Pediatr Ann 35:280-6. 2006.... - Partial external biliary diversion for intractable pruritus and xanthomas in Alagille syndromeKaran M Emerick
Department of Pediatrics, Children s Memorial Hospital, Northwestern University Medical School, Chicago, IL 60614, USA
Hepatology 35:1501-6. 2002..PEBD should be considered as a therapeutic option for these patients before referral for liver transplantation because of morbid complications... - Neonatal hemochromatosis: a congenital alloimmune hepatitisPeter F Whitington
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Children s Memorial Hospital, Chicago, Illinois, USA
Semin Liver Dis 27:243-50. 2007..Given the pathology of the liver and the mechanism of liver injury, NH could best be classified as congenital alloimmune hepatitis... - Fetal and infantile hemochromatosisPeter F Whitington
Department of Pediatrics, Northwestern University Feinberg Medical School, Children's Memorial Hospital, Chicago, IL, USA
Hepatology 43:654-60. 2006 - Disparate clinical presentation of neonatal hemochromatosis in twinsUdeme D Ekong
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Children's Memorial Hospital, Chicago, Illinois, USA
Pediatrics 116:e880-4. 2005..They also suggest that affected infants may be missed when using routine clinical testing, which would lead to the apparent rate of recurrence, understating the actual recurrence rate... - A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000Benjamin L Shneider
Department of Pediatrics, Mount Sinai Medical Center, New York, NY 10029, Department of Biostatistics, University of Michigan, Ann Arbor, MI, and Department of Pediatrics, Children s Hospital of Philadelphia, PA, USA
J Pediatr 148:467-474. 2006..To determine the prognostic factors and optimal approaches to the diagnosis and management of biliary atresia, the leading indication for liver transplantation in children... - Improved neurocognitive function after radiologic closure of congenital portosystemic shuntsYasemen Eroglu
Department of Pediatrics, The Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
J Pediatr Gastroenterol Nutr 39:410-7. 2004 - Outcome of pregnancies at risk for neonatal hemochromatosis is improved by treatment with high-dose intravenous immunoglobulinPeter F Whitington
Children s Memorial Hospital, Mail Box 57, 2300 Children s Plaza, Chicago, IL 60614, USA
Pediatrics 121:e1615-21. 2008..A secondary objective was to use a prospectively collected data set to examine questions of vital interest about neonatal hemochromatosis... - Pancreatic adenocarcinoma in type 2 progressive familial intrahepatic cholestasisLee M Bass
Northwestern University Feinberg School of Medicine, Department of Pediatrics, Chicago, Illinois, USA
BMC Gastroenterol 10:30. 2010..BSEP disease results from mutations in ABCB11, which encodes the bile salt export pump (BSEP). BSEP disease is associated with an increased risk of hepatobiliary cancer... - Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosisCara L Mack
Departments of Pediatrics and Surgery, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA
J Pediatr 142:197-9. 2003..Coagulation factors had returned to normal by one year. The data suggest that portal venous flow is essential for maintaining normal coagulation... - Liver transplantation in neonatesShikha S Sundaram
Siragusa Transplantation Center, Children's Memorial Hospital, The Feinberg School of Medicine of Northwestern University, Chicago, IL 60614, USA
Liver Transpl 9:783-8. 2003..Very little is known about this frontier of transplantation. Our intent is to provide an overview of neonatal OLT using all available data and our experience in the field... - Liver transplantation in childrenPeter F Whitington
The Children's Memorial Hospital and Northwestern University School of Medicine, Chicago, Illinois, USA
J Pediatr Gastroenterol Nutr 35:S44-50. 2002 - Molecular basis of neonatal cholestasisKaran McBride Emerick
Division of Gastroenterology, Hepatology and Nutrition, Children s Memorial Hospital, Northwestern University Medical School, Chicago, Illinois, USA
Pediatr Clin North Am 49:221-35. 2002..The understanding of the functional differences between the immature and mature liver is key to the understanding of neonatal cholestasis... - Outcomes in pediatric autoimmune hepatitisMaria T Greene
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Memorial Hospital, Chicago, IL 60614, USA
Curr Gastroenterol Rep 11:248-51. 2009..In about 10% of patients, treatment fails, requiring alternative therapies and/or liver transplantation as liver disease progresses. Less than 10% of children with autoimmune hepatitis die during 10 years of follow-up... - Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's diseaseYu Oyama
Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
Gastroenterology 128:552-63. 2005..Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantation (HSCT) can induce a remission... - Intracranial vascular abnormalities in patients with Alagille syndromeKaran M Emerick
Division of Gastroenterology, The Children s Memorial Hospital and Northwestern University Medical School, Chicago, Illinois 60614, USA
J Pediatr Gastroenterol Nutr 41:99-107. 2005.... - Relative elevations of serum alanine and aspartate aminotransferase in muscular dystrophyRohit Kohli
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Children's Memorial Medical Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60614, USA
J Pediatr Gastroenterol Nutr 41:121-4. 2005 - Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn ratsMark S Wainwright
Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Stroke 37:524-30. 2006..We used a newborn rat model of hypoxia-ischemia (HI) to test the hypothesis that HI alters acyl-CoA:CoA homeostasis and that this effect can be prevented by treatment with carnitine... - Hepatic adenoma in an adolescent with elevated androgen levelsMaria Triantafyllopoulou
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Memorial Hospital, Northwestern University, Chicago, Illinois 60614, USA
J Pediatr Gastroenterol Nutr 44:640-2. 2007 - Neonatal hemochromatosisA S Knisely
Institute of Liver Studies, King's College Hospital, London, UK
Gastroenterol Clin North Am 32:877-89, vi-vii. 2003..Immunomodulation during pregnancy at risk appears to lessen the severity of disease... - Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammationCara L Mack
Department of Pediatric, The Children s Hospital, University of Colorado Health Science Center, Denver, CO 80218, USA
Pediatr Res 56:79-87. 2004.... - Subacute nonsuppurative cholangitis (cholangitis lenta) in pediatric liver transplant patientsChieh Chung Lin
Department of Pediatrics, School of Medicine, Taichung Veterans General Hospital, Chung Shan Medical University, Taichung, Taiwan
J Pediatr Gastroenterol Nutr 45:228-33. 2007.... - Growth failure and outcomes in infants with biliary atresia: a report from the Biliary Atresia Research ConsortiumPatricia A DeRusso
Johns Hopkins School of Medicine and The Johns Hopkins Children s Center, Baltimore, Maryland, USA
Hepatology 46:1632-8. 2007..The combination of intermediate bilirubin concentrations and poor mean weight z-scores 3 months after HPE was also associated with poor clinical outcome... - Guideline for the evaluation of cholestatic jaundice in infants: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and NutritionVirginia Moyer
J Pediatr Gastroenterol Nutr 39:115-28. 2004..These recommendations are a general guideline and are not intended as a substitute for clinical judgment or as a protocol for the care of all patients with this problem...
Research Grants
- Clinical Center--Biliary Atresia Clinical Research ConsortiumPeter Whitington; Fiscal Year: 2007..and #4 To examine the hypothesis that biliary atresia is a viral-induced, immune mediated disease. ..