Research Topics
Genomes and Genes | Shiva ShahraraSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Publications
IL-17 contributes to angiogenesis in rheumatoid arthritisSarah R Pickens
Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Immunol 184:3233-41. 2010..These observations identify a novel function for IL-17 as an angiogenic mediator in RA, supporting IL-17 as a therapeutic target in RA...- Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritisJeffrey H Ruth
Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Drive, Ann Arbor, MI 48109, USA
Arthritis Res Ther 12:R118. 2010..The function of interleukin-18 (IL-18) was investigated in pertinent animal models of rodent rheumatoid arthritis (RA) to determine its proinflammatory and monocyte recruitment properties... - TH-17 cells in rheumatoid arthritisShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University 240 E Huron, Chicago, IL 60611, USA
Arthritis Res Ther 10:R93. 2008.... - IL-17 induces monocyte migration in rheumatoid arthritisShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University Chicago, IL 60611, USA
J Immunol 182:3884-91. 2009..These observations suggest that IL-17 may be important in recruiting monocytes into the joints of patients with RA, supporting IL-17 as a therapeutic target in RA... - RANTES modulates TLR4-induced cytokine secretion in human peripheral blood monocytesShiva Shahrara
Department of Medicine, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Immunol 177:5077-87. 2006..These observations suggest that the therapeutic neutralization of RANTES, in addition to decreasing the trafficking of leukocytes, may have a proinflammatory effect at the site of established chronic inflammation... - IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 inductionShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Immunol 184:4479-87. 2010.... - Amelioration of rat adjuvant-induced arthritis by Met-RANTESShiva Shahrara
Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Arthritis Rheum 52:1907-19. 2005..The aim of this study was to investigate whether Met-RANTES could ameliorate adjuvant-induced arthritis (AIA) in the rat... - Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritisShiva Shahrara
Department of Medicine, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Immunol 180:3447-56. 2008..Our results indicate that inhibition of MCP-1 with P8A-MCP-1 after the onset of clinically detectable disease ameliorates AIA and decreases macrophage accumulation, cytokine expression, and p38 MAPK activation within the joint... - Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritisJeffrey H Ruth
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
Lab Invest 83:579-88. 2003..These results further indicate that expression of CCR6, the receptor for MIP-3alpha, can be correlated with RA development... - Anti-CXCL5 therapy ameliorates IL-17-induced arthritis by decreasing joint vascularizationSarah R Pickens
Division of Rheumatology, Department of Medicine, University of Illinois at Chicago, MSB 835S Wolcott Ave, E807 E809, Chicago, IL 60612, USA
Angiogenesis 14:443-55. 2011..These results suggest that blockade of CXCL5 can modulate IL-17-induced inflammation in part by reducing joint blood vessel formation through a non-overlapping IL-17 mechanism... - Characterization of CCL19 and CCL21 in rheumatoid arthritisSarah R Pickens
Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Arthritis Rheum 63:914-22. 2011..To characterize the expression of CCL19 and CCL21 in rheumatoid arthritis (RA) synovial tissue (ST) and to examine their regulation and pathogenetic role in macrophages and RA ST fibroblasts... - Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritisShiva Shahrara
Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Arthritis Rheum 48:3568-83. 2003..Furthermore, we investigated the signaling pathways associated with CC receptors as well as the cell type distribution of the receptors... - Local expression of interleukin-27 ameliorates collagen-induced arthritisSarah R Pickens
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Arthritis Rheum 63:2289-98. 2011..To determine the mechanism of action of interleukin-27 (IL-27) against rheumatoid arthritis (RA)... - Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissueShiva Shahrara
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
Arthritis Res 4:201-8. 2002..In conclusion, the dominance of Ang-1 mRNA and protein expression over Ang-2 is in agreement with an active neovascularization in RA synovial tissue... - Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissuesShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Arthritis Res Ther 9:R112. 2007..Activation of the FAK family signaling cascade on RA and OA lining cells may be responsible for cell adhesion and migration into the diseased STs. Therapies targeting this novel signaling pathway may be beneficial in RA... - Prostate secretions from men with chronic pelvic pain syndrome inhibit proinflammatory mediatorsPraveen Thumbikat
Department of Urology and Division of Rheumatology, Northwestern University, Chicago, Illinois 60611, USA
J Urol 184:1536-42. 2010..We examined the functional effects of chemokines in expressed prostatic secretions of patients with chronic pelvic pain syndrome... - Characterization of CCL19 and CCL21 in rheumatoid arthritisSarah R Pickens
Feinberg School of Medicine, Northwestern University, Chicago, Illinois
Arthritis Rheum 63:914-22. 2011..To characterize the expression of CCL19 and CCL21 in rheumatoid arthritis (RA) synovial tissue (ST) and to examine their regulation and pathogenetic role in macrophages and RA ST fibroblasts... - Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritisSarah R Pickens
University of Illinois at Chicago, Department of Medicine, Chicago, IL 60612, USA
Arthritis Rheum 63:2884-93. 2011.... - Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healingMinghua Wu
Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 E Huron St, Chicago, IL 60611, USA
Am J Pathol 175:1041-55. 2009..Together, these results point to the fundamental role that Egr-1 plays in the regulation of transforming growth factor-ss-dependent physiological and pathological matrix remodeling... - Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndromeNaresh V Desireddi
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Urol 179:1857-61; discussion 1861-2. 2008..In addition, chemokine levels were correlated with clinical pain as determined by the National Institutes of Health chronic prostatitis symptom index... - CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathwayJeffrey H Ruth
University of Michigan Medical School, Ann Arbor 48109-0680, USA
Arthritis Rheum 54:765-78. 2006..CONCLUSION: Taken together, these results point to a unique role for CXCL16 as a premier MNC recruiter in RA and suggest additional therapeutic possibilities, targeting CXCL16, its receptor, or its signaling pathways... - In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritisChristian S Haas
University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Arthritis Rheum 56:2535-48. 2007..The purpose of this study was to use a gene therapy approach to investigate the role of IL-13 in angiogenesis in vivo, using a rat adjuvant-induced arthritis model of RA... - Expression of mucin 3 and mucin 5AC in arthritic synovial tissueMichael V Volin
Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, USA
Arthritis Rheum 58:46-52. 2008..MUC gene expression has been found to be altered in many cancers and inflammatory states. This study was undertaken to examine its expression in synovial tissue (ST) and role in arthritis...
Research Grants
- Chemokine receptor antagonists in inflammatory diseaseShiva Shahrara; Fiscal Year: 2007..Achieving these goals may give us valuable information in regard to molecular inflammatory mechanisms involved in atherosclerosis and RA. ..