Research Topics
| Richard PopeSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Detail Information
Publications
TH-17 cells in rheumatoid arthritisShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University 240 E Huron, Chicago, IL 60611, USA
Arthritis Res Ther 10:R93. 2008....- More than just B-cell inhibitionEric M Ruderman
Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, 240 E, Huron Street, McGaw M300, Chicago, IL 60611, USA
Arthritis Res Ther 13:125. 2011..However, other kinase inhibitors have failed to transition from animal models to human therapy, so it remains to be seen whether a Btk inhibitor will have a role in the RA treatment armamentarium... - The role of interleukin-1 and the inflammasome in gout: implications for therapyRichard M Pope
Northwestern University Feinberg School of Medicine, and the Jesse Brown VA Medical Center, Chicago, Illinois 60611, USA
Arthritis Rheum 56:3183-8. 2007 - Apoptosis as a therapeutic tool in rheumatoid arthritisRichard M Pope
Division of Rheumatology, Northwestern University, The Feinberg School of Medicine, Ward 3 315, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
Nat Rev Immunol 2:527-35. 2002..In this article, I characterize the mechanisms that prevent the apoptosis of chronic inflammatory cells in the RA joint, to identify potential new targets for the treatment of RA... - IL-17 contributes to angiogenesis in rheumatoid arthritisSarah R Pickens
Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Immunol 184:3233-41. 2010..These observations identify a novel function for IL-17 as an angiogenic mediator in RA, supporting IL-17 as a therapeutic target in RA... - Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammationYingyu Ma
Northwestern University Feinberg School of Medicine and Veteran s Administration Medical Center, Chicago, Lakeside Division, Department of Medicine, Division of Rheumatology, 300 E Superior Avenue, Tarry 3 713, Chicago, Illinois 60611, USA
Nat Immunol 5:380-7. 2004..These observations document a unique mechanism whereby Fas-FasL interactions enhance activation through the IL-1R1 or Toll-like receptor 4 pathway, which may contribute to the pathogenesis of chronic arthritis... - RANTES modulates TLR4-induced cytokine secretion in human peripheral blood monocytesShiva Shahrara
Department of Medicine, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Immunol 177:5077-87. 2006..These observations suggest that the therapeutic neutralization of RANTES, in addition to decreasing the trafficking of leukocytes, may have a proinflammatory effect at the site of established chronic inflammation... - Drug Insight: abatacept for the treatment of rheumatoid arthritisEric M Ruderman
Division of Rheumatology, Northwestern University Feinberg School of Medicine, 675 North St Clair Street, Chicago, IL 60611, USA
Nat Clin Pract Rheumatol 2:654-60. 2006..This article discusses the proposed mechanism of action of abatacept and reviews the data from phase II and phase III clinical trials on the safety and efficacy of this drug in RA... - IL-17 induces monocyte migration in rheumatoid arthritisShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University Chicago, IL 60611, USA
J Immunol 182:3884-91. 2009..These observations suggest that IL-17 may be important in recruiting monocytes into the joints of patients with RA, supporting IL-17 as a therapeutic target in RA... - Increased macrophage activation mediated through toll-like receptors in rheumatoid arthritisQiquan Huang
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Arthritis Rheum 56:2192-201. 2007..This study was undertaken to analyze macrophages obtained from the joints of RA patients in order to characterize the expression of Toll-like receptor 2 (TLR-2) and TLR-4 and the responses to TLR ligation... - Amelioration of rat adjuvant-induced arthritis by Met-RANTESShiva Shahrara
Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Arthritis Rheum 52:1907-19. 2005..The aim of this study was to investigate whether Met-RANTES could ameliorate adjuvant-induced arthritis (AIA) in the rat... - IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblastsHarris Perlman
Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Immunol 170:838-45. 2003..These data suggest that alterations in p21 expression may activate AP-1 leading to enhanced proinflammatory cytokine and MMP production and development of autoimmune disease... - Homocysteine, bone mineral density, and fracture risk over 2 years of followup in women with and without systemic lupus erythematosusElisa Y Rhew
Department of Medicine, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Rheumatol 35:230-6. 2008..To examine the relationship of baseline homocysteine levels with bone mineral density (BMD) and incidence of fractures over 2 years in women with and without systemic lupus erythematosus (SLE)... - Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritisShiva Shahrara
Department of Medicine, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Immunol 180:3447-56. 2008..Our results indicate that inhibition of MCP-1 with P8A-MCP-1 after the onset of clinically detectable disease ameliorates AIA and decreases macrophage accumulation, cytokine expression, and p38 MAPK activation within the joint... - Mcl-1 is essential for the survival of synovial fibroblasts in rheumatoid arthritisHongtao Liu
Division of Rheumatology, Northwestern University Feinberg School of Medicine and The Jesse Brown Veterans Affairs Chicago Heathcare System, IL 60611, USA
J Immunol 175:8337-45. 2005..These observations document a critical role for Mcl-1 in protecting against apoptosis in RA and suggest that Mc1-1 is a potential therapeutic target in this disease... - Prostate secretions from men with chronic pelvic pain syndrome inhibit proinflammatory mediatorsPraveen Thumbikat
Department of Urology and Division of Rheumatology, Northwestern University, Chicago, Illinois 60611, USA
J Urol 184:1536-42. 2010..We examined the functional effects of chemokines in expressed prostatic secretions of patients with chronic pelvic pain syndrome... - Rheumatoid arthritis synovial fluid macrophages express decreased tumor necrosis factor-related apoptosis-inducing ligand R2 and increased decoy receptor tumor necrosis factor-related apoptosis-inducing ligand R3Harris Perlman
Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
Arthritis Rheum 48:3096-101. 2003..These observations do not support a potential therapeutic role for TRAIL in RA... - The evolving clinical profile of abatacept (CTLA4-Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritisEric M Ruderman
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Arthritis Res Ther 7:S21-5. 2005..This review describes the molecular and biologic bases for the use of abatacept in rheumatoid arthritis and summarizes the current clinical data on its safety and effectiveness in this disease... - IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 inductionShiva Shahrara
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Immunol 184:4479-87. 2010.... - Innate immunity and rheumatoid arthritisAngelica Gierut
Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 240 East Huron Street, McGaw M300, Chicago, IL 60611, USA
Rheum Dis Clin North Am 36:271-96. 2010..As the understanding continues to expand, enticing targets for new therapeutic interventions continue to be identified. This article focuses on cells of myelomonocytic origin, their receptors, and factors that interact with them... - Apoptosis in rheumatoid arthritis: friend or foeHongtao Liu
Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
Rheum Dis Clin North Am 30:603-25, x. 2004.... - NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosisShaochun Bai
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Arthritis Rheum 50:3844-55. 2004..The resistance of RA synovial fibroblasts to TNFalpha-induced apoptosis is mediated by the NF-kappaB-regulated expression of FLIP. These observations support the role of NF-kappaB and FLIP as attractive therapeutic targets in RA... - Modifications in adenoviral coat fiber proteins and transcriptional regulatory sequences enhance transgene expressionHarris Perlman
Division of Rheumatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
J Rheumatol 29:1593-600. 2002..CONCLUSION: Adenovirus attachment and uptake by cells and promoter strength limit transgene expression from conventional adenoviral vectors in models of rheumatoid arthritis... - Regulation of Mcl-1 expression in rheumatoid arthritis synovial macrophagesHongtao Liu
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Arthritis Rheum 54:3174-81. 2006..This study was undertaken to characterize the expression, regulation, and function of the antiapoptotic Bcl-2 family member Mcl-1 in macrophages isolated from the joints of patients with RA... - TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondriaHongtao Liu
Northwestern University Feinberg School of Medicine and Lakeside Division, Division of Rheumatology, Department of Medicine, Veterans Administration Medical Center, Chicago, IL 60611, USA
J Immunol 172:1907-15. 2004.... - TNFalpha-induced macrophage death via caspase-dependent and independent pathwaysTri M Tran
Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 E Huron Street, Chicago, IL 60611, USA
Apoptosis 14:320-32. 2009..These observations demonstrate that TNFalpha triggers both caspase 8-dependent and -independent cell death pathways in macrophages and identify a novel mechanism by which A20 protects these cells against both pathways... - Activation-induced degradation of FLIP(L) is mediated via the phosphatidylinositol 3-kinase/Akt signaling pathway in macrophagesBo Shi
Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, Illinois 60611, USA
J Biol Chem 284:14513-23. 2009..Thus, these observations document a novel mechanism where by TNFalpha facilitates the reduction of FLIP(L) protein, which is dependent on the phosphatidylinositol 3-kinase/Akt signaling... - Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signalingQi Quan Huang
Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Immunol 182:4965-73. 2009.... - The role of toll-like receptors in rheumatoid arthritisQi Quan Huang
Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Curr Rheumatol Rep 11:357-64. 2009..The data support a potential role for suppression of TLR signaling as a novel therapeutic approach in patients with RA... - Role of H2-calponin in regulating macrophage motility and phagocytosisQi Quan Huang
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Biol Chem 283:25887-99. 2008..The lack of h2-calponin also significantly increased macrophage phagocytotic activity, suggesting a novel mechanism to regulate phagocyte functions... - Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndromeNaresh V Desireddi
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Urol 179:1857-61; discussion 1861-2. 2008..In addition, chemokine levels were correlated with clinical pain as determined by the National Institutes of Health chronic prostatitis symptom index... - Phagocytes: mechanisms of inflammation and tissue destructionHongtao Liu
Division of Rheumatology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Ward 3-315, Chicago, IL 60611, USA
Rheum Dis Clin North Am 30:19-39, v. 2004..Once in the inflammatory joint or the vasculitic lesion, macrophages and neutrophils contribute to the pathology observed. This article examines the mechanisms by which phagocytes contribute to the pathogenesis of these diseases... - The role of macrophages in rheumatoid arthritisYingyu Ma
Division of Rheumatology, Department of Medicine, VA Medical Center, Chicago, Lakeside Division, Northwestern University Feinberg School of Medicine, 240 E. Huron St, Suite 2300, Chicago, IL 60611, USA
Curr Pharm Des 11:569-80. 2005.... - NF-kappaB protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting proteinYingyu Ma
Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine and the Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
J Biol Chem 280:41827-34. 2005..These observations demonstrate that following TLR4 ligation by lipopolysaccharide, NF-kappaB is a critical determinant of macrophage life or death, whereas caspase 8 determines the pathway employed... - Transcriptional diversity during monocyte to macrophage differentiationHongtao Liu
Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL 60611, United States
Immunol Lett 117:70-80. 2008..These observations suggest that examination of the transcriptional profile in monocytes and macrophages in patients may identify relevant therapeutic targets in diseases mediated by macrophages... - Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosisVladislav Temkin
Division of Rheumatology, Northwestern University Feinberg School of Medicine, 240 E Huron, Suite 2300, Chicago, IL 60611, USA
Mol Cell Biol 26:2215-25. 2006..These observations demonstrate a novel mechanism initiated through death receptor ligation and mediated by RIP that results in the suppression of ANT activity and necrosis... - Myeloid cell leukemia-1 as a therapeutic targetArthur M Mandelin
Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Expert Opin Ther Targets 11:363-73. 2007..This review characterizes the role of Mcl-1 in the regulation of apoptosis and the promotion of disease, and defines novel strategies that have been identified to target this molecule... - The role of apoptosis in rheumatoid arthritisHongtao Liu
Northwestern University Feinberg School of Medicine and the VA Medical Center, Chicago, Lakeside Division Department of Medicine, Division of Rheumatology, 303 East Chicago Avenue, Tarry 3-377, Chicago IL 60611, USA
Curr Opin Pharmacol 3:317-22. 2003.... - Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survivalHongtao Liu
Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Ward 3 315, Chicago, IL 60611, USA
Blood 102:344-52. 2003..These observations demonstrate that the STAT3-mediated expression of Mcl-1 is essential for the survival of primary human in vitro differentiated macrophages... - Apigenin, a dietary flavonoid, sensitizes human T cells for activation-induced cell death by inhibiting PKB/Akt and NF-kappaB activation pathwayLuting Xu
Division of Rheumatology, Departments of Medicine and Microbiology Immunology, Northwestern University, Feinberg School of Medicine, 240 East Huron, St McGaw M300, Chicago, IL 60611, United States
Immunol Lett 121:74-83. 2008.... - ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritisJeffrey H Ruth
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
Cytometry A 71:317-26. 2007..Therefore, in the same joint, there may exist positive and negative influences on the inflammatory response, and perhaps, the negative signals dominate as joint inflammation resolves... - Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblastsKathleen Bradley
Saint Louis University, School of Medicine, St Louis, Missouri 63104, USA
Arthritis Rheum 50:78-87. 2004..Therefore, we sought to determine if the tumor suppressor gene product retinoblastoma (Rb), a negative regulator of cell cycle activity, inhibits IL-6, MMP-1, and p38 in RA synovial fibroblasts...
Research Grants
- The role of Mcl-1 in the macrophages and RARichard Pope; Fiscal Year: 2003..These experiments will provide new and important information concerning the novel role of Mcl-1, which may provide insights that will lead to the development of improved therapy for patients with RA. ..
- Role of Stress-Response Protein gp96 in the Persistence of Rheumatoid ArthritisRichard Pope; Fiscal Year: 2009..The work proposed in this study is aimed at identifying novel mechanisms contributing to the pathogenesis of rheumatoid arthritis, which would define new therapeutic targets. ..
- Role of Flip MacrophagesRichard Pope; Fiscal Year: 2007..These studies will provide insights into mechanisms that contribute to the pathogenesis of RA and potentially the development of new therapeutic strategies. ..
- Multidisciplinary Clinical Research Center in RheumatologyRichard Pope; Fiscal Year: 2007..Moreover, it fosters interactions among centers throughout the United States most notably the University of Illinois at Chicago and the University of Pittsburgh. ..
- POSTDOCTORAL RHEUMATOLOGY TRAININGRichard Pope; Fiscal Year: 2007....
- The role of Mcl-1 in the macrophages and RARichard Pope; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page.................................................................................................................................................. 1 Description, ..
- The role of Mcl-1 in the macrophages and RARichard Pope; Fiscal Year: 2006..These experiments will provide new and important information concerning the novel role of Mcl-1, which may provide insights that will lead to the development of improved therapy for patients with RA. ..
- Role of Stress-Response Protein gp96 in the Persistence of Rheumatoid ArthritisRichard M Pope; Fiscal Year: 2010..The work proposed in this study is aimed at identifying novel mechanisms contributing to the pathogenesis of rheumatoid arthritis, which would define new therapeutic targets. ..