Thomas Mustoe

..We conclude that Ad-hTERT is an effective and novel approach to treating the ischemic wounds of elderly patients...

..These innovative ideas and therapies could be of substantial interest for clinicians and researchers, while further offering significant benefit to patients with chronic wounds...

..Furthermore, the lack of alteration of Smad-dependent intermediates by Smad3 overexpression suggests the activation of Smad-independent pathways in ischemia...

..A brief review of postoperative pain management, and the management of postoperative nausea and vomiting, is also included...

..The current study was designed to compare the transcriptomes of oral mucosal and skin wounds in order to identify critical differences in the healing response at these two sites using an unbiased approach...

..Therefore, most investigators rely on supraplatysmal dissection and medial plication of the platysma to achieve satisfactory cervical contours, especially in patients with difficult necks...

..The mechanism of action of silicone therapy has not been completely determined but is likely to involve occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts...

..Additionally, treatment comprising a combination of these approaches has demonstrated success...

..In the spectrum of factors contributing to dermal scar, the epidermis and its downstream effectors offer promising new targets for the development of antiscar therapies...

..However, it is highly desirable that many standard practices and new emerging therapies undergo large-scale studies with long-term follow-up before being recommended conclusively as alternative therapies for scar management...

..The authors aimed to quantify overall patient satisfaction with three breast reconstruction techniques and identify factors that have influenced satisfaction...

..Ultrastructural analysis suggests that occluded wounds may be in an advanced state of wound repair. Occlusion may mediate its effects through establishing homeostasis of the epidermal barrier layer...

..By remaining attentive to patient concerns and optimizing perioperative care, we can improve the subjective experience for our patients...

..Increasing experience and small modifications in local anesthesia and surgical technique have strengthened the authors' conviction that conscious sedation is the preferred method of anesthesia for most patients undergoing abdominoplasty...

..The findings suggest the progress of cutaneous defect repair can be enhanced by ex vivo cell delivery in fibrin sealant...

..CONCLUSION: Our results suggest that epithelial wound healing is improved by transdermal sustained-delivery treatment with 100% oxygen...

..The authors' hypothesis was that a more superficial plane of abdominal flap elevation during abdominoplasty would decrease the postoperative need for drains...

..These findings raise the possibility that reduced up-regulation of these cytoprotective genes may be causally linked to cutaneous I-R injury...

..Its limited participation in early healing implies that it may be a useful and specific target for modulating hypertrophic scarring following injury...

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..Furthermore, our data suggest that the degree and the duration of occlusion are most important for reducing scar tissue formation...

..deficient in biofilm formation. This represents the first direct evidence for the effect of bacterial biofilms on cutaneous wound healing...

..In summary, the results of this study indicate that occlusive therapy was able to decrease dermal fibrosis by hydrating the epidermis and altering the pro- and antifibrotic signals produced following injury...

..Oxygen can be ruled out as a mechanism of action of silicone occlusive treatment. Hydration of the keratinocytes seems to be the key stimulus...

..The results demonstrate the distinctive phenotype presented by the clinically relevant combination of age and ischemia in an in vivo model of cutaneous wound healing...

..These results suggest that inhibition of prolyl 4-hydroxylase may be a suitable agent for topical treatment for the prevention of hypertrophic scar tissue...

..This article analyzes current knowledge on growth factors as therapeutic agents and speculates on their future potential, with an analysis of successes and failures to date...

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..We propose a standardized approach to wound healing assays that will elucidate critical cellular and molecular mechanisms and potential therapies...

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..The article concludes with a discussion of why hypoxia and hyperoxia intercurrently play an important role in wound healing. Hypoxia-inducible factor 1 is crucial in that interplay...

..01). Our results point not only to the potential use of PCP inhibitors to mitigate hypertrophic scarring but also to the temporal importance of drug delivery for antiscarring therapy...

..With a relative paucity of complications, this conceptually ideal modification is technically simple and aesthetically comparable to our transverse rectus abdominis muscle flap results...

..Optimisation of this novel application in retroviral gene therapy could lead to effective anti-scarring strategies...

..Together, these results point to the fundamental role that Egr-1 plays in the regulation of transforming growth factor-ss-dependent physiological and pathological matrix remodeling...

..Smad3 is a positive effector of transforming growth factor-beta superfamily signal transduction. Such approaches are the latest evolution of work championed by Hunt and colleagues over the past 4 decades...

..Application of this model to the vast number of transgenic mice available will further our understanding of the mechanism of pressure sore development...

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..001). HSP70-transfection of aged HDF with plasmid reduced LDH-release by 29%. CONCLUSIONS: Heat pre-conditioning fails to protect aged HDF to oxidative or hypoxic stress due in part to impaired HSP70 induction compared to young...

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..Our findings also demonstrate a novel role for fibulin-5 and suggest that altering extracellular matrix protein production through gene therapy may provide a novel means to promote wound healing...

..The caudal ischemic rabbit ear model showed significantly higher levels of hypoxia. Use of a validated model that produces sufficient tissue levels of hypoxia is recommended for meaningful study of ischemic wound healing...

..This study sought to evaluate the effect of ultraviolet light exposure on scar hypertrophy in an established rabbit model of cutaneous scarring...

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..A battery of standard and impaired wound healing models, when used in a systematic and combinatorial fashion, should yield significant contributions to wound healing research...

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