Research Topics
Genomes and Genes
| Hiroaki KiyokawaSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Senescence and cell cycle controlHiroaki Kiyokawa
Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Results Probl Cell Differ 42:257-70. 2006..This review is focused on recent advances in understanding the roles of the tumor-suppressive pathways in senescence...- Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesisEvan C Osmundson
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 E, Chicago Avenue, Chicago, IL 60611, USA
Cell Div 4:14. 2009..Finally, deregulated Smurf2 activity may contribute to carcinogenesis by perturbed mitotic control... - In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targetsHiroaki Kiyokawa
Department of Molecular Pharmacology and Biological Chemistry, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
Anticancer Agents Med Chem 8:832-6. 2008..These biological properties of CDC25 phosphatases provide significant insight into the pathobiology of cancer and scientific foundation for anti-CDC25 therapeutic intervention... - Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in miceDipankar Ray
Department of Molecular Pharmacology and Biological Chemistry, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
Cancer Res 67:6605-11. 2007..These results suggest that Cdc25A plays a rate-limiting role in transformation and tumor initiation mediated by ras activation... - Cdk4 is indispensable for postnatal proliferation of the anterior pituitarySiwanon Jirawatnotai
Department of Biochemistry, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
J Biol Chem 279:51100-6. 2004..Taken together, Cdk4 is dispensable for prenatal development of the pituitary or proliferation of other non-endocrine tissues but indispensable specifically for postnatal proliferation of somato/lactotrophs... - The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesisKatherine Krupczak-Hollis
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
Dev Biol 276:74-88. 2004.... - CDC25A phosphatase: a rate-limiting oncogene that determines genomic stabilityDipankar Ray
Department of Molecular Pharmacology and Biological Chemistry, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
Cancer Res 68:1251-3. 2008..These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy... - Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent mannerJennifer E Skeen
Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
Cancer Cell 10:269-80. 2006..Surprisingly, upon mTORC1 hyperactivation, the reduction in Akt activity does not impair cell proliferation and susceptibility to oncogenic transformation; thus, Akt may mediate these processes exclusively via mTORC1... - CDC25A levels determine the balance of proliferation and checkpoint responseDipankar Ray
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinios, USA
Cell Cycle 6:3039-42. 2007..Here we provide our views on the role of CDC25A in cancer development and genomic stability, discussing insights from our recent studies on Cdc25A knockout mice and MMTV-CDC25A transgenic mice... - Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent mannerDipankar Ray
Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, IL 60607, USA
Mol Cell Biol 25:3338-47. 2005..These data suggest that Smad3 plays a key role in the regulation of Cdc25A ubiquitination by SCFbeta-TrCP and that Cdc25A stabilization observed in various cancers could be associated with defects in the TGF-beta-Smad3 pathway... - Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesisDipankar Ray
Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611, USA
Neoplasia 13:439-44. 2011..Thus, we propose that CDC25A-CDK2 pathway is critical for the oncogenic action of ErbB-2 in mammary epithelial cells, in a manner similar to Cyclin D1/CDK4 pathway... - Constitutive and UV-induced fibronectin degradation is a ubiquitination-dependent process controlled by beta-TrCPDipankar Ray
Department of Molecular Pharmacology and Biological Chemistry, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
J Biol Chem 281:23060-5. 2006..Taken together, constitutive FN degradation, as well as UV-induced degradation, is ubiquitination dependent and controlled by beta-TrCP... - Different requirements for the cytostatic and apoptotic effects of type I interferons. Induction of apoptosis requires ARF but not p53 in osteosarcoma cell linesRaudel Sandoval
Department of Pharmacology, University of Illinois, Chicago, 60612, USA
J Biol Chem 279:32275-80. 2004.... - p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic processWinna Taylor
University of Illinois at Chicago, Department of Surgery, Division of Surgical Oncology, 840 S Wood St, Chicago, IL 60612, USA
BMC Cancer 10:541. 2010..To test this hypothesis, we examined the efficacy of 9-cis retinoic acid (9cRA) to suppress prostate cell proliferation (PECP) and carcinogenesis in p27(Kip1) deficient mice... - Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instabilityDipankar Ray
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
Cancer Res 67:984-91. 2007..These data indicate that deregulated control of cellular CDC25A levels leads to in vivo genomic instability, which cooperates with the neu-ras oncogenic pathway in mammary tumorigenesis... - The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 cooperate to restrict proliferative life span in differentiating ovarian cellsSiwanon Jirawatnotai
Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
J Biol Chem 278:17021-7. 2003..Thus, the cooperation of p27(Kip1) and p21(Cip1) is critical for withdrawal of granulosa cells from the cell cycle, in concert with luteal differentiation and possibly culture-induced senescence... - Rapamycin inhibits growth factor-induced cell cycle regulation in pancreatic beta cellsAmy Aronovitz
Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Investig Med 56:985-96. 2008..As rapamycin is used to treat islet transplant recipients, these results suggest that rapamycin could have deleterious effects on islet proliferation and function over time... - The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpointEvan C Osmundson
Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Cell Biol 183:267-77. 2008..Mad2 is mislocalized in Smurf2-depleted cells, suggesting that Smurf2 regulates the localization and stability of Mad2. These data indicate that Smurf2 is a novel mitotic regulator... - The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activationFinola E Moore
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Cell Div 5:22. 2010..These observations suggest that the stable complex of Smurf2 and NEDD9 is required for timely entry into mitosis via Aurora A activation... - Tumor-prone phenotype of the DDB2-deficient miceTaewon Yoon
Department of Biochemistry and Molecular Genetics M C 669, University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL 60607, USA
Oncogene 24:469-78. 2005..The observations suggest that, in addition to DNA repair, the other interactions of DDB2 are significant in its tumor suppression function... - The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regenerationXinhe Wang
Department of Molecular Genetics, University of Illinois College of Medicine, 900 South Ashland Avenue, Chicago, IL 60607, USA
Proc Natl Acad Sci U S A 99:16881-6. 2002..Our present study shows that the mammalian Foxm1b transcription factor regulates expression of cell cycle proteins essential for hepatocyte entry into DNA replication and mitosis... - Engagement of protein kinase C-theta in interferon signaling in T-cellsKishore K Srivastava
Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA
J Biol Chem 279:29911-20. 2004..Altogether, these findings demonstrate that PKC-theta is an interferon-inducible kinase and strongly suggest that it plays an important role in the generation of interferon-responses in T-cells... - Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescenceXianghong Zou
Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
Genes Dev 16:2923-34. 2002..Therefore, Cdk4 is essential for immortalization, and suppression of Cdk4 could be a prospective strategy to recruit cells with inactive Arf/p53 pathway to senescence... - Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissuesPaula L Miliani de Marval
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
Mol Cell Biol 24:7538-47. 2004..These results show that CDK4 mediates the proliferative and oncogenic activities of Myc in vivo through a mechanism that involves the sequestration of specific CDK inhibitors... - A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genesRaudel Sandoval
Department of Pharmacology, University of Illinois at Chicago, IL 60612, USA
Exp Cell Res 312:2465-75. 2006..Interestingly, mutation of BARA/LIN-9 restores the expression of E2F target genes in CDK4 null MEFs, indicating that the wild-type protein plays a role in the expression of genes required for the G1/S transition...
Research Grants
- Role of Cdc25A in breast cancerHiroaki Kiyokawa; Fiscal Year: 2009..We expect that these studies will provide us with significant insight into the role of Cdc25A stabilization in breast cancer development and a molecular handle to develop effective therapies to target the oncogene. ..
- Cell Cycle Genes and Female Reproductive FunctionHiroaki Kiyokawa; Fiscal Year: 2007..No available cell line would generate such information. It is our expectation that this program contributes to a scientific foundation for therapeutic targets against infertility and other ovarian diseases. ..
- Role of G1-Cdks in immortalization and oncogenesisHiroaki Kiyokawa; Fiscal Year: 2006..abstract_text> ..
- CELL CYCLE GENES IN OVARIAN FUNCTION AND ONCOGENESISHiroaki Kiyokawa; Fiscal Year: 2002..abstract_text> ..