Michael Caplan

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi The role of human milk in necrotizing enterocolitis
    Michael S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare Research Institute, Northwestern University Medical School, IL 60201, USA
    Adv Exp Med Biol 503:83-90. 2002
  2. ncbi New concepts in necrotizing enterocolitis
    M S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, Illinois 60201, USA
    Curr Opin Pediatr 13:111-5. 2001
  3. ncbi Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model
    M S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, Illinois 60201, USA
    Pediatr Res 49:647-52. 2001
  4. ncbi The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis
    M S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, Illinois 60201, USA
    Lipids 36:1053-7. 2001
  5. ncbi The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis
    Michael S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare and The Evanston Northwestern Healthcare Research Institute, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201, USA
    Semin Pediatr Surg 14:145-51. 2005
  6. ncbi Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis
    Jing Lu
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Evanston, IL 60201, USA
    Pediatr Res 68:225-30. 2010
  7. ncbi Inter-alpha inhibitor protein level in neonates predicts necrotizing enterocolitis
    Hala Chaaban
    Department of Pediatrics, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    J Pediatr 157:757-61. 2010
  8. ncbi Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells
    Jing Lu
    Department of Pediatrics, Northwestern University, Feinberg School of Medicine, 2650 Ridge Ave, Evanston, IL 60201, USA
    Am J Physiol Gastrointest Liver Physiol 286:G340-50. 2004
  9. ncbi The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis
    Brandy L Frost
    Department of Pediatrics, Evanston Northwestern Healthcare Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
    Semin Perinatol 32:100-6. 2008
  10. ncbi Neonatal necrotizing enterocolitis. Introduction
    Michael S Caplan
    Semin Perinatol 32:69. 2008

Research Grants

  1. The Role of PAF and TLR in NEC
    Michael Caplan; Fiscal Year: 2007
  2. THE ROLE OF PAF IN NEONATAL-NECROTIZING ENTEROCOLITIS
    Michael Caplan; Fiscal Year: 2003
  3. The Role of PAF and TLR in NEC
    Michael S Caplan; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi The role of human milk in necrotizing enterocolitis
    Michael S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare Research Institute, Northwestern University Medical School, IL 60201, USA
    Adv Exp Med Biol 503:83-90. 2002
  2. ncbi New concepts in necrotizing enterocolitis
    M S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, Illinois 60201, USA
    Curr Opin Pediatr 13:111-5. 2001
    ....
  3. ncbi Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model
    M S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, Illinois 60201, USA
    Pediatr Res 49:647-52. 2001
    ..Addition of nucleotides with PUFA abrogated the beneficial effects of PUFA on intestinal inflammation. We conclude that PUFA reduces the incidence of NEC and intestinal inflammation in a neonatal rat model...
  4. ncbi The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis
    M S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, Illinois 60201, USA
    Lipids 36:1053-7. 2001
    ..Our findings suggest that PUFA reduce the incidence of NEC by modulating PAF metabolism and endotoxin translocation...
  5. ncbi The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis
    Michael S Caplan
    Department of Pediatrics, Evanston Northwestern Healthcare and The Evanston Northwestern Healthcare Research Institute, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201, USA
    Semin Pediatr Surg 14:145-51. 2005
    ..Understanding the regulation of these molecular interactions may provide new approaches for prevention or treatment of this dreaded condition...
  6. ncbi Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis
    Jing Lu
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Evanston, IL 60201, USA
    Pediatr Res 68:225-30. 2010
    ..In conclusion, the data support a protective role for endogenous PAF-AH in the development of NEC, and because preterm neonates have endogenous PAF-AH deficiency, this may place them at increased risk for disease...
  7. ncbi Inter-alpha inhibitor protein level in neonates predicts necrotizing enterocolitis
    Hala Chaaban
    Department of Pediatrics, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    J Pediatr 157:757-61. 2010
    ..To compare inter-alpha inhibitor protein (IaIp) levels in neonates with proven necrotizing enterocolitis (NEC) and neonates with other, nonspecific abdominal disorders...
  8. ncbi Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells
    Jing Lu
    Department of Pediatrics, Northwestern University, Feinberg School of Medicine, 2650 Ridge Ave, Evanston, IL 60201, USA
    Am J Physiol Gastrointest Liver Physiol 286:G340-50. 2004
    ..A better understanding of the role of PAF and Bcl-2 family of apoptosis regulators in epithelial cell death might aid design of better therapeutic or preventive strategies for IBDs...
  9. ncbi The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis
    Brandy L Frost
    Department of Pediatrics, Evanston Northwestern Healthcare Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
    Semin Perinatol 32:100-6. 2008
    ..In this review, we examine the key points in the signaling pathways involved in NEC, and potential strategies for prevention and treatment of this dreaded disease...
  10. ncbi Neonatal necrotizing enterocolitis. Introduction
    Michael S Caplan
    Semin Perinatol 32:69. 2008
  11. ncbi Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model
    Jing Lu
    Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Pediatr Res 61:427-32. 2007
    ..These results suggest that PUFA modulates gene expression of key factors involved in experimental NEC pathogenesis. These effects might in part explain the protective effect of PUFA on neonatal NEC...
  12. ncbi Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis
    Isabelle G De Plaen
    Department of Pediatrics, Children s Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA
    Pediatr Res 61:716-21. 2007
    ..Our findings therefore lead us to conclude that selective NF-kappaB inhibition represents a promising therapeutic strategy for NEC...
  13. ncbi Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts
    Wei Hsueh
    Department of Pathology, Children s Memorial Hospital, Northwestern University Medical School, 2300 Children s Plaza, Chicago, IL 60614, USA
    Pediatr Dev Pathol 6:6-23. 2003
    ..The former maintains intestinal perfusion and the integrity of the mucosal barrier, and the latter keep virulent bacteria in check. The development of tissue injury depends on the balance between injurious and protective mechanisms...
  14. ncbi Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis
    Tamas Jilling
    Department of Pediatrics, Evanston Northwestern Healthcare Research Institute, and Northwestern University, Feinberg School of Medicine, Evanston, IL 60201, USA
    Pediatr Res 55:622-9. 2004
    ..These findings indicate that in neonatal rats FFCAS induces epithelial apoptosis that serves as an underlying cause for subsequent gross tissue necrosis...
  15. ncbi Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis
    Michael D Amer
    Department of Pediatrics, Evanston Hospital and Northwestern University Medical School, Evanston, IL 60201, USA
    Biol Neonate 85:159-66. 2004
    ....
  16. ncbi The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis
    Tamas Jilling
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    J Immunol 177:3273-82. 2006
    ..In summary, bacteria and TLR4 play significant roles in experimental NEC, likely via an interaction of intraluminal bacteria and aberrantly overexpressed TLR4 in enterocytes...
  17. ncbi Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat
    Larry G Thaete
    Department of Obstetrics and Gynecology, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    J Soc Gynecol Investig 10:145-50. 2003
    ..To determine the impact of exogenous platelet-activating factor (PAF) on pregnancy outcome in the rat...
  18. ncbi Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells
    Jing Lu
    Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1181-90. 2008
    ....
  19. ncbi Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers
    Erika C Claud
    Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital East Building, Charlestown 02129, USA
    Pediatr Res 52:155-62. 2002
    ..Thus, mucosal acting PAF directly and specifically stimulates ion transport via activation of an apical Cl(-) channel in intestinal epithelial cell monolayers independent of prostaglandin biosynthesis...
  20. ncbi Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase
    Xiao-Wu Qu
    Department of Pathology, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Crit Care Med 33:1050-6. 2005
    ..CONCLUSIONS: We conclude that nNOS selectively regulates intestinal perfusion. Tetrahydrobiopterin prevents PAF-induced intestinal injury, probably by stabilizing nNOS and maintaining intestinal perfusion...

Research Grants12

  1. The Role of PAF and TLR in NEC
    Michael Caplan; Fiscal Year: 2007
    ..The proposed studies will elucidate the interactions between PAF and TLR signaling, and clarify whether these pathways play an underlying role in the initiation of neonatal NEC. ..
  2. THE ROLE OF PAF IN NEONATAL-NECROTIZING ENTEROCOLITIS
    Michael Caplan; Fiscal Year: 2003
    ..Results from these experiments should clarify key mechanisms linking the risk factors of NEC with the pathologic outcome, and may provide new strategies for the prevention of NEC in premature newborns. ..
  3. The Role of PAF and TLR in NEC
    Michael S Caplan; Fiscal Year: 2010
    ..The proposed studies will elucidate the interactions between PAF and TLR signaling, and clarify whether these pathways play an underlying role in the initiation of neonatal NEC. ..