Alan Buchman

..Its role in the treatment of active Crohn's disease (CD) was assessed in a pilot, randomized, placebo-controlled, double-blinded, dose-ranging study...

..Previous studies have shown that plasma and urinary free choline concentrations decrease significantly during a marathon, and that these decreases may be associated with decreased performance...

..Eight parenteral nutrition (PN)-dependent subjects (3 men, 5 women), aged 49.9+/-10.2 years, with a residual small bowel length of 71.8+/-152.0 cm that ended in a jejunostomy, were studied...

..The pathophysiology of total parenteral nutrition-associated liver disease is discussed as well as potential management options...

..This study was undertaken to determine whether choline deficiency is a risk factor for development of catheter thrombosis...

..Elevated intestinal P-gp could have resulted in decreased tacrolimus absorption, thereby leading to decreased blood concentration and decreased efficacy in this patient. The cause and prevalence of this phenomenon are unknown...

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..The source of many catheter-related infections is contamination of the catheter hub. Herein an antimicrobial catheter cap, the AB Cap is described...

..If these interventions fail, intestinal transplantation should be performed expeditiously before development of ESLD mandates simultaneous inclusion of a liver graft as well...

..A preliminary pilot study suggested choline-supplemented TPN may be useful in reversal of these hepatic abnormalities...

..These side effects are discussed in detail. The side effects from corticosteroids emulate from exogenous hypercortisolism, which is similar to the clinical syndrome of Cushing's disease...

..not routinely added that should be part of a parenteral nutrition (PN) formula? Were other micronutrients present but in inappropriate amounts? How are various micronutrient requirements altered in the critically or chronically ill?..

..Provision of intravenous choline ameliorates hepatic steatosis associated with parenteral nutrition infusion...

..MELD and CRP are promising clinical markers of disease progression in IF patients on PN...

..For those patients who experience both intestinal failure and life-threatening complications from total parenteral nutrition, bowel transplantation may be indicated...

..This review addresses the etiologies of malnutrition, methods used to assess nutritional status, and appropriate treatment strategies...

..But United Network for Organ Sharing outcomes reports have not routinely distinguished between the intestine candidate subgroups that are listed only for an intestine and those that are also listed for a liver...

..This is a review of the osteoporotic therapies that have recently become available and a discussion of emerging options. An overview on current practice guidelines is provided...

..We hypothesized that serum B12 concentration would become elevated in intestinal failure-associated liver disease and would reflect in disease severity...

..The aim of this review was to describe currently known enterocyte-targeted growth factors, their mechanisms of action, and their potential therapeutic utility...

..We report three cases of MCD involving the perianal and vulvar skin that initially presented with vulvar pain...

..Our objective was to describe our experience with its use in a cohort of patients which, to our knowledge, represents the largest North American cohort described to date...

..Biosynthesis of FCho may be insufficient during PN therapy. The aim of the study was to examine the status of FCho and related metabolites in infants on prolonged (> or =4 weeks) PN...

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..Selected topics including celiac disease, disaccharidase deficiencies, short bowel syndrome, and Crohn disease are discussed...

..These approaches may lead clinicians to derive a personalized nutritional prescription based on individual genetic variations and may result in a significant impact on IBD treatment...

..Intestinal transplantation remains an option for those who have developed life-threatening complications from PN and cannot be managed using more conservative techniques...

..Careful monitoring of patients is warranted in these circumstances and combined transplantation of the liver and small bowel may be the only possibility for long-term survival for such patients with progressive liver disease...

..Although the significance of this is unclear, a shorter bowel length may potentially predispose people to the development of Crohn's disease via an alteration of intestinal motility and intestinal flora...

..This case report suggests that small bowel radiographic studies may not be as sensitive for the detection of clinically significant luminal lesions as once thought...

..In this report, we discuss the alterations in somatostatin receptors that occur with Crohn's disease and describe a case of an OctreoScan-positive inflammatory mass mimicking a carcinoid tumor...

..Given that patients with clinically suspected CD recurrence may not have active disease, unnecessary and potentially harmful empiric therapy is not warranted without imaging...

..The nutritional aspect of short-bowel syndrome is complex, with the ultimate goal of weaning the patients from parenteral nutrition. Intestinal transplant is a treatment option for select patients...

..The purpose of this study is to compare the diagnostic yield of the Given M2A videocapsule endoscope to conventional push enteroscopy...

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..Further evaluation led to a diagnosis of Sjogren's syndrome. Sjogren's syndrome should be considered in patients with underlying Crohn's disease who develop a constellation of constitutional, joint, and sicca symptoms...

..Furthermore, most employers were perceived by their employees with IBD as having fair attitudes toward the compensation provided for their employees with IBD...