DANIEL C BATLLE

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy
    Daniel Batlle
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Kidney Int 81:520-8. 2012
  2. ncbi Baseline characteristics of patients with chronic kidney disease stage 3 and stage 4 in Spain: the MERENA observational cohort study
    Alberto Martinez-Castelao
    Nephrology Unit, Hospital Universitario Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    BMC Nephrol 12:53. 2011
  3. ncbi Distal renal tubular acidosis and the potassium enigma
    Daniel Batlle
    Division of Nephrology Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Semin Nephrol 26:471-8. 2006
  4. ncbi Clinical and cellular markers of diabetic nephropathy
    Daniel Batlle
    Division of Nephrology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611-3008, USA
    Kidney Int 63:2319-30. 2003
  5. ncbi New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy
    Daniel Batlle
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Nephrol Hypertens 17:250-7. 2008
  6. ncbi Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension
    Jan Wysocki
    Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hypertension 55:90-8. 2010
  7. ncbi Pharmacologic modulation of ACE2 expression
    Maria Jose Soler
    Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior, Chicago, IL 60611, USA
    Curr Hypertens Rep 10:410-4. 2008
  8. ncbi Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease
    Jan Wysocki
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Chicago, IL 60611, USA
    Curr Hypertens Rep 10:70-7. 2008
  9. ncbi Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan
    Maria Jose Soler
    Department of Medicine, Division of Nephrology and Hypertension, The Feinberg School of Medicine, Northwestern Univ, 320 E Superior, Chicago, IL 60611, USA
    Am J Physiol Renal Physiol 296:F398-405. 2009
  10. ncbi Na+/H+ exchange activity and NHE-3 expression in renal tubules from the spontaneously hypertensive rat
    Michael S LaPointe
    Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Medical School, Searle 10 475, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Kidney Int 62:157-65. 2002

Research Grants

  1. CELL GROWTH, NA/H EXCHANGE, AND CYCLINS IN IDDM PATIEN
    Daniel Batlle; Fiscal Year: 2002
  2. Nocturnal Hypertension and Prevention of Microalbuminuria in Type I Diabetics
    Daniel Batlle; Fiscal Year: 2007
  3. Strategies for ACE2 Amplification to Treat Diabetic Kidney Disease
    Daniel Batlle; Fiscal Year: 2010

Collaborators

Detail Information

Publications32

  1. ncbi Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy
    Daniel Batlle
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Kidney Int 81:520-8. 2012
    ....
  2. ncbi Baseline characteristics of patients with chronic kidney disease stage 3 and stage 4 in Spain: the MERENA observational cohort study
    Alberto Martinez-Castelao
    Nephrology Unit, Hospital Universitario Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    BMC Nephrol 12:53. 2011
    ....
  3. ncbi Distal renal tubular acidosis and the potassium enigma
    Daniel Batlle
    Division of Nephrology Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Semin Nephrol 26:471-8. 2006
    ..This shows that a unique defect involving the H+/K+-adenosine triphosphatase leading to renal potassium wastage cannot explain the hypokalemia seen in virtually all types of classic distal RTA...
  4. ncbi Clinical and cellular markers of diabetic nephropathy
    Daniel Batlle
    Division of Nephrology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611-3008, USA
    Kidney Int 63:2319-30. 2003
  5. ncbi New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy
    Daniel Batlle
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Nephrol Hypertens 17:250-7. 2008
    ....
  6. ncbi Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension
    Jan Wysocki
    Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hypertension 55:90-8. 2010
    ..Increasing ACE2 activity may provide a new therapeutic target in states of Ang II overactivity by enhancing its degradation, an approach that differs from the current focus on blocking Ang II formation and action...
  7. ncbi Pharmacologic modulation of ACE2 expression
    Maria Jose Soler
    Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior, Chicago, IL 60611, USA
    Curr Hypertens Rep 10:410-4. 2008
    ..In this review, we briefly summarize recent studies dealing with pharmacologic interventions that modulate ACE2 expression. ACE2 amplification may have a potential therapeutic role for kidney disease and hypertension...
  8. ncbi Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease
    Jan Wysocki
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Chicago, IL 60611, USA
    Curr Hypertens Rep 10:70-7. 2008
    ..Studies using models of ACE2 ablation and the pharmacologic administration of an ACE2 inhibitor suggest that decreased ACE2 activity alone or in combination with increased ACE activity may play a role in both diseases...
  9. ncbi Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan
    Maria Jose Soler
    Department of Medicine, Division of Nephrology and Hypertension, The Feinberg School of Medicine, Northwestern Univ, 320 E Superior, Chicago, IL 60611, USA
    Am J Physiol Renal Physiol 296:F398-405. 2009
    ..Amplification of ACE2 in the renal vasculature may contribute to the therapeutic action of telmisartan by increasing angiotensin II degradation...
  10. ncbi Na+/H+ exchange activity and NHE-3 expression in renal tubules from the spontaneously hypertensive rat
    Michael S LaPointe
    Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Medical School, Searle 10 475, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Kidney Int 62:157-65. 2002
    ..Studies have reported that apical NHE-3 translocates to internal pools, thereby facilitating natriuresis when blood pressure increases abruptly...
  11. ncbi Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism
    Stuart M Sprague
    Division of Nephrology Hypertension and Department of Medicine, Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
    Kidney Int 63:1483-90. 2003
    ..A comparative study was undertaken in order to determine whether paricalcitol provides a therapeutic advantage to calcitriol...
  12. ncbi Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?
    Minghao Ye
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Ill 60611, USA
    Hypertension 43:1120-5. 2004
    ..We propose that the pattern of low ACE protein coupled with increased ACE 2 protein expression may be renoprotective in early stages of diabetes...
  13. ncbi Acid-base and potassium disorders in liver disease
    Shubhada N Ahya
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Semin Nephrol 26:466-70. 2006
    ..Potassium disorders are often the result of the therapies used to treat advanced liver disease...
  14. ncbi Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease
    Xiaofang Wang
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nephrol Dial Transplant 24:526-34. 2009
    ..By both mechanisms, CaR activation could lower intracellular cAMP and inhibit renal cyst growth...
  15. ncbi The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells
    Emilia Lecuona
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Biol Cell 14:3888-97. 2003
    ..Accordingly, ISO regulates Na,K-ATPase exocytosis in AEC via the activation of beta2-adrenergic receptor, Gs, PKA, Gi, RhoA, and ROCK...
  16. ncbi Nocturnal hypertension: will control of nighttime blood pressure prevent progression of diabetic renal disease?
    K M Moorthi
    Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, 320 East Superior, Searle 10-475, Chicago, IL 60611, USA
    Curr Hypertens Rep 6:393-9. 2004
    ..There is a compelling need for studies showing that treating nocturnal hypertension in diabetes can prevent renal disease progression...
  17. ncbi Predicting the development of diabetic nephropathy and its progression
    Josette William
    Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Adv Chronic Kidney Dis 12:202-11. 2005
    ....
  18. ncbi ACE and ACE2 activity in diabetic mice
    Jan Wysocki
    Division of Nephrology Hypertension, The Feinberg School of Medicine, Northwestern University, Searle 10 475, 320 E Superior, Chicago, IL 60611, USA
    Diabetes 55:2132-9. 2006
    ....
  19. ncbi Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes
    Minghao Ye
    Department of Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA
    J Am Soc Nephrol 17:3067-75. 2006
    ....
  20. ncbi Prevalence, treatment, and control of hypertension in chronic hemodialysis patients in the United States
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and RLR VA Medical Center, Indianapolis 46202, USA
    Am J Med 115:291-7. 2003
    ..Hypertension is common in chronic hemodialysis patients, yet there are limited data on the epidemiology of hypertension in these patients in the United States...
  21. ncbi Circadian changes in blood pressure and their relationships to the development of microalbuminuria in type 1 diabetic patients
    Donn Hogan
    Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, 320 E. Superior Street, 10-475 Searle Building, Chicago, IL 60611, USA
    Curr Diab Rep 2:539-44. 2002
    ..An increase in systolic blood pressure during sleep precedes the development of microalbuminuria and may play a causative role in its development...
  22. ncbi Acute renal failure and severe hypertension from a page kidney post-transplant biopsy
    Maria Aurora Posadas
    Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA
    ScientificWorldJournal 10:1539-42. 2010
    ..Early recognition and rapid intervention are needed in order to correct hypertension and reverse acute renal failure in Page kidney occurring in renal transplant recipients...
  23. ncbi Images in clinical medicine. Bilateral kidney calcifications
    Andres Serrano
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 359:e1. 2008
  24. ncbi Angiotensin II increases H+-ATPase B1 subunit expression in medullary collecting ducts
    Patricia Valles
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, IL 60611, USA
    Hypertension 45:818-23. 2005
    ....
  25. ncbi Comorbidity and cardiovascular risk factors in patients with chronic kidney disease
    James Paparello
    Department of Medicine, The Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA
    Semin Nephrol 22:494-506. 2002
    ..When possible, recommendations for treatment are provided based on the information reviewed...
  26. ncbi Apelin and ACE2 in cardiovascular disease
    Anastasia Z Kalea
    Northwestern University, Feinberg School of Medicine, Division of Nephrology Hypertension, 303 East Chicago Avenue, Tarry Building 4 750, Chicago, IL 60611 3008, USA
    Curr Opin Investig Drugs 11:273-82. 2010
    ....
  27. ncbi The role of comprehensive renal clinic in chronic kidney disease stabilization and management: The Northwestern experience
    Cybele Ghossein
    Division of Nephrology/Hypertension, Feinberg School of Medicine, Northwestern University, Northwestern Memorial Hospital, Chicago, IL 60611, USA
    Semin Nephrol 22:526-32. 2002
    ..Our data suggests that stabilization of GFR is a goal that can be accomplished with comprehensive renal care provided in an organized clinic setting...
  28. ncbi Low mortality and key aspects of delivery of care for end-stage renal disease in Italy
    Alexander Lauder
    Northwestern University Feinberg School of Medicine, Chicago, USA
    ScientificWorldJournal 9:349-59. 2009
    ..These findings portray key aspects of the contemporary delivery of care for Italian dialysis patients and provide a platform for international comparison of healthcare systems for ESRD...
  29. ncbi Stabilization of glomerular filtration rate in advanced chronic kidney disease: a two-year follow-up of a cohort of chronic kidney disease patients stages 4 and 5
    Andres Serrano
    Division of Nephrology Hypertension, Northwestern University, The Feinberg School of Medicine and Northwestern Memorial Hospital, Chicago, IL 60611, USA
    Adv Chronic Kidney Dis 14:105-12. 2007
    ..Although the precise reason for the stabilization of GFR cannot be elucidated from this study, our data are "proof of concept" that CKD outcomes can be improved in a CKD clinic setting...
  30. ncbi High CO2 levels impair alveolar epithelial function independently of pH
    Arturo Briva
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 2:e1238. 2007
    ..Our study examines the effects of increased pCO2 on the epithelial Na,K-ATPase a major contributor to alveolar fluid reabsorption which is a marker of alveolar epithelial function...
  31. ncbi Intestinal ileus as a possible cause of hypobicarbonatemia
    Andres Serrano
    Division of Nephrology and Hypertension, Northwestern University Feiberg School of Medicine, Chicago, IL, USA
    ScientificWorldJournal 7:75-9. 2007
    ..The cause of the falling plasma bicarbonate was ascribed to intestinal bicarbonate sequestration owing to the enhancement of chloride-bicarbonate exchange in a dilated paralyzed colon...
  32. ncbi Epigenetic and genetic analysis of p16 in dermal fibroblasts from type 1 diabetic patients with nephropathy
    Lixia Zeng
    Department of Medicine, Division of Nephrology Hypertension, The Feinberg School of Medicine of Northwestern University, Chicago, Illinois 60611, USA
    Kidney Int 63:2094-102. 2003
    ..In this study, we examined the correlation between p16 protein expression in cultured dermal fibroblasts from type 1 diabetic patients and the presence of DN...

Research Grants8

  1. CELL GROWTH, NA/H EXCHANGE, AND CYCLINS IN IDDM PATIEN
    Daniel Batlle; Fiscal Year: 2002
    ....
  2. Nocturnal Hypertension and Prevention of Microalbuminuria in Type I Diabetics
    Daniel Batlle; Fiscal Year: 2007
    ..Moreover, these studies will reveal the impact of long-term ACE inhibition on nocturnal hypertension and endothelial dysfunction in normotensive type 1 diabetics. ..
  3. Strategies for ACE2 Amplification to Treat Diabetic Kidney Disease
    Daniel Batlle; Fiscal Year: 2010
    ....