Research Topics
Species | APKAR APKARIANSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Publications
Inflammatory and neuropathic pain animals exhibit distinct responses to innocuous thermal and motoric challengesRami Jabakhanji
Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL, 60611, USA
Mol Pain 2:1. 2006..This suggests that the angle-track and thermal-track may be useful in assessing automatically the global impact of different types of pain on behavior...- A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritisMarwan N Baliki
Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL 60611, USA
Mol Pain 4:47. 2008..Moreover, lidocaine patch treatment modulates distinct brain circuitry in each condition, yet in OA we observe divergent results with fMRI and with questionnaire based instruments... - Single subject pharmacological-MRI (phMRI) study: modulation of brain activity of psoriatic arthritis pain by cyclooxygenase-2 inhibitorM Baliki
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Mol Pain 1:32. 2005..This approach may have diagnostic and prognostic utility... - Spared nerve injury rats exhibit thermal hyperalgesia on an automated operant dynamic thermal escape taskMarwan Baliki
Department of Physiology, Northwestern University Medical School, Chicago, IL, 60611, USA
Mol Pain 1:18. 2005..It is argued that the dynamic thermal operant task reveals the relevance of the neuropathic injury associated pain-like behavior in relation to the whole organism... - Identifying directed links in large scale functional networks: application to brain fMRIGuillermo A Cecchi
Computational Biology Center, T, J, Watson IBM Research Center, Yorktwon Heights, New York, USA
BMC Cell Biol 8:S5. 2007..The method provides a snapshot of the ongoing dynamics of the brain without sacrificing resolution, as the analysis is tractable even for very large numbers of voxels... - Expression of IL-1beta in supraspinal brain regions in rats with neuropathic painA Vania Apkarian
Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago, IL 60611, USA
Neurosci Lett 407:176-81. 2006..The results indicate that neuro-immune activation in neuropathic pain conditions includes supraspinal brain regions, suggesting cytokine modulation of supraspinal circuitry of pain in neuropathic conditions... - Pain perception in relation to emotional learningA Vania Apkarian
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60610, USA
Curr Opin Neurobiol 18:464-8. 2008..This review is a discussion of the rationale and evidence for the interaction between these modalities, emphasizing underlying mechanisms... - Human brain mechanisms of pain perception and regulation in health and diseaseA Vania Apkarian
Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
Eur J Pain 9:463-84. 2005..These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic pain conditions... - Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic painA V Apkarian
Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, IL 60611, USA
Neurosci Lett 311:193-7. 2001..These findings provide evidence for abnormal brain responses to pain in patients with chronic SMP, which engages prefrontal/limbic networks more extensively than in acute pain-states... - Chronic back pain is associated with decreased prefrontal and thalamic gray matter densityA Vania Apkarian
Department of Physiology and Institute of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Neurosci 24:10410-5. 2004..Our results imply that CBP is accompanied by brain atrophy and suggest that the pathophysiology of chronic pain includes thalamocortical processes... - Towards a theory of chronic painA Vania Apkarian
Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
Prog Neurobiol 87:81-97. 2009.... - Chronic pain patients are impaired on an emotional decision-making taskA Vania Apkarian
Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, IL 60611, USA
Pain 108:129-36. 2004..Our evidence indicates that chronic pain is associated with a specific cognitive deficit, which may impact everyday behavior especially in risky, emotionally laden, situations... - The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regionsPaul Y Geha
Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Neuron 60:570-81. 2008..These abnormalities encompass emotional, autonomic, and pain perception regions, implying that they likely play a critical role in the global clinical picture of CRPS... - Neurological effects of chronic painMarwan N Baliki
Northwestern University, Chicago, IL 60611, USA
J Pain Palliat Care Pharmacother 21:59-61. 2007..Studies of neurobiological changes that occur in patients with chronic pain are described. These include grey matter loss, effects on emotional processing and learning... - Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic painAlexia E Metz
Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 106:2423-8. 2009.... - Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic painMarwan N Baliki
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Neuron 66:149-60. 2010..Therefore, in contrast to somatosensory pathways, which reflect sensory properties of acute noxious stimuli, NAc activity in humans encodes its predicted value and anticipates its analgesic potential on chronic pain. VIDEO ABSTRACT:.. - Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back painMarwan N Baliki
Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Neurosci 26:12165-73. 2006.... - Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitorMaria V Centeno
Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
Pain 145:176-83. 2009..The results suggest that such an approach may provide a novel venue for treating clinical pain conditions... - Cortical pathophysiology of chronic painA Vania Apkarian
Department of Physiology and Neuroscience Institute, Department of Surgery, and Department of Anesthesia, Northwestern University Medical School, Tarry Bldg. 5-703, Chicago, IL 60611, USA
Novartis Found Symp 261:239-45; discussion 245-61. 2004..An overview of the mechanisms that may be pertinent to the observed results is included... - D-cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitryMagali Millecamps
Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
Pain 132:108-23. 2007..These findings indicate that limbic NMDA-mediated circuitry is involved in long-term reduction in neuropathic pain behavior... - Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamicsMarwan N Baliki
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Neurosci 28:1398-403. 2008..These findings demonstrate that chronic pain has a widespread impact on overall brain function, and suggest that disruptions of the DMN may underlie the cognitive and behavioral impairments accompanying chronic pain... - Dynamics of pain: fractal dimension of temporal variability of spontaneous pain differentiates between pain StatesJennifer M Foss
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Neurophysiol 95:730-6. 2006..These results show that measures of variability of spontaneous pain differentiate between chronic pain conditions, and thus may have mechanistic and clinical utility... - Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in ratsLi Ru Zhao
Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Ill, USA
Stroke 38:2804-11. 2007..We have previously observed that SCF and G-CSF have neuroprotective and functional effects on acute brain ischemia. In the present study, the beneficial effects of SCF and G-CSF on chronic brain ischemia were determined... - The characteristics of cyclical and non-cyclical mastalgia: a prospective study using a modified McGill Pain QuestionnaireSeema A Khan
Department of Surgery, Northwestern University, Chicago, IL 60611, USA
Breast Cancer Res Treat 75:147-57. 2002..96). Studies of breast pain should include both groups to better understand and characterize these differences, particularly with regard to a possible connection with breast cancer risk... - Spontaneous pain and brain activity in neuropathic pain: functional MRI and pharmacologic functional MRI studiesMarwan N Baliki
Northwestern University Feinberg School of Medicine, Department of Physiology, Chicago, IL 60611, USA
Curr Pain Headache Rep 11:171-7. 2007.... - Brain imaging findings in neuropathic painPaul Y Geha
Northwestern University Feinberg School of Medicine, Department of Physiology, 303 East Chicago Avenue, Chicago, IL 60611, USA
Curr Pain Headache Rep 9:184-8. 2005..Overall, the reasons for the limited contribution of these techniques to the science of chronic pain are presented in this article... - Mastalgia and breast cancer: a protective association?Seema A Khan
Department of Surgery, Northwestern Medical School, Chicago, IL 60611, USA
Cancer Detect Prev 26:192-6. 2002..Further investigation of this possible protective association is warranted...
Research Grants
- CORTICAL PATHOPHYSIOLOGY OF PAINAPKAR VANIA APKARIAN; Fiscal Year: 2010..We also plan to build models for predicting chronic pain based on brain parameters measured in the subacute stage. ..
- Chronic Pain and Emotional Learning and MemoryAPKAR VANIA APKARIAN; Fiscal Year: 2010..Moreover, we seek to identify the role of endogenous cytokines, as markers for plasticity and learning, in the chronic pain. . ..
- Chronic Pain and Emotional Learning and MemoryAPKAR APKARIAN; Fiscal Year: 2009..Moreover, we seek to identify the role of endogenous cytokines, as markers for plasticity and learning, in the chronic pain. . ..
- Characterizing temporal dynamics of spontaneous painAPKAR APKARIAN; Fiscal Year: 2007....
- CORTICAL PATHOPHYSIOLOGY OF PAINAPKAR APKARIAN; Fiscal Year: 2006..In Aim 4 we study the reversibility of cognitive deficits, chemical concentration decreases and gray matter density decreases in OAP and PHN patients before and after pain therapy. ..
- Cortical Dynamics for Pain Perception in Behaving RatsAPKAR APKARIAN; Fiscal Year: 2005..abstract_text> ..
- CORTICAL PATHOPHYSIOLOGY OF PAINAPKAR APKARIAN; Fiscal Year: 2002..Overall the studies are designed to examine chronic pain by functional imaging, brain biochemistry, and cognitive abilities. The results, if successful, have the potential of being used in the clinic as diagnostic or prognostic tools. ..
- CORTICAL PATHOPHYSIOLOGY OF PAINAPKAR VANIA APKARIAN; Fiscal Year: 2010..We also plan to build models for predicting chronic pain based on brain parameters measured in the subacute stage. ..