Research Topics
Species | E M JohnSummaryAffiliation: Northern California Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
Medical radiation exposure and breast cancer risk: findings from the Breast Cancer Family RegistryEsther M John
Northern California Cancer Center, Fremont, CA 94538, USA
Int J Cancer 121:386-94. 2007..Given the widespread and increasing use of medical diagnostic radiation, continued surveillance of breast cancer risk is warranted, particularly in women at specific genetic risk, such as those carrying mutations in BRCA1 or BRCA2...- Exploring the link between MORF4L1 and risk of breast cancerGriselda Martrat
Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
Breast Cancer Res 13:R40. 2011..To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens... - Recent changes in breast cancer incidence and risk factor prevalence in San Francisco Bay area and California women: 1988 to 2004Theresa H M Keegan
Northern California Cancer Center, 2201 Walnut Ave, Suite 300, Fremont, CA 94538, USA
Breast Cancer Res 9:R62. 2007..In light of these reports, we examined recent changes in breast cancer incidence and risk factor prevalence among non-Hispanic white women in the SFBA and other regions of California... - The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancerEsther M John
Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
Breast Cancer Res 6:R375-89. 2004.... - Sun exposure and prostate cancer risk: evidence for a protective effect of early-life exposureEsther M John
Northern California Cancer Center, Fremont, CA 94538, USA
Cancer Epidemiol Biomarkers Prev 16:1283-6. 2007..47; 95% confidence interval, 0.23-0.99). These findings suggest that, in addition to sun exposure in adulthood, sun exposure in early life protects against prostate cancer... - Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic populationEsther M John
Northern California Cancer Center, Fremont, CA 94538, USA
Am J Epidemiol 166:1409-19. 2007..Localized breast cancer was not associated with sun exposure or VDR genotype. This study supports the hypothesis that sunlight exposure reduces risk of advanced breast cancer among women with light skin pigmentation... - Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groupsEsther M John
Northern California Cancer Center, Fremont, CA 94538 2334, USA
JAMA 298:2869-76. 2007..Information on the prevalence of pathogenic BRCA1 mutation carriers in racial/ethnic minority populations is limited... - Migration history, acculturation, and breast cancer risk in Hispanic womenEsther M John
Northern California Cancer Center, Suite 300, 2201 Walnut Avenue, Fremont, CA 94538, USA
Cancer Epidemiol Biomarkers Prev 14:2905-13. 2005..We examined the influence of migration history and acculturation on breast cancer risk in Hispanic women ages 35 to 79 years... - Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancerEsther M John
Northern California Cancer Center, Fremont, California 94538, USA
Cancer Res 65:5470-9. 2005..46 to 0.67. Our findings support the hypothesis that sun exposure and VDR polymorphisms together play important roles in the etiology of prostate cancer... - Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination SurveyE M John
Northern California Cancer Center, Union City 94587, USA
Cancer Epidemiol Biomarkers Prev 8:399-406. 1999..These data support the hypothesis that sunlight and dietary vitamin D reduce the risk of breast cancer... - Lifetime physical activity and breast cancer risk in a multiethnic population: the San Francisco Bay area breast cancer studyEsther M John
Northern California Cancer Center, Union City, California 94587, USA
Cancer Epidemiol Biomarkers Prev 12:1143-52. 2003..Because few of the currently known risk factors for breast cancer are modifiable, these results underline the public health importance of promoting physically active lifestyles... - Sources of phytoestrogen exposure among non-Asian women in California, USAP L Horn-Ross
Northern California Cancer Center, Union City 94587, USA
Cancer Causes Control 11:299-302. 2000..This paper describes the first application of this database and the primary sources of phytoestrogen consumption in non-Asian women... - Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States)P L Horn-Ross
Northern California Cancer Center, Union City 94587, USA
Cancer Causes Control 11:289-98. 2000..The purpose of this research was to develop such a database for use with food-frequency questionnaires in large epidemiologic studies... - Second primary breast cancer occurrence according to hormone receptor statusAllison W Kurian
Northern California Cancer Center, 2201 Walnut Ave, Fremont, CA 94538 2334, USA
J Natl Cancer Inst 101:1058-65. 2009..Little is known about differences in risk for second primary breast cancers related to the estrogen and progesterone receptor (hormone receptor [HR]) status of the first tumor... - Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer StudyP L Horn-Ross
Northern California Cancer Center, Union City, CA 94587, USA
Am J Epidemiol 154:434-41. 2001..Phytoestrogens appear to have little effect on breast cancer risk at the levels commonly consumed by non-Asian US women: an average intake equivalent to less than one serving of tofu per week... - Breast cancer incidence patterns among California Hispanic women: differences by nativity and residence in an enclaveTheresa H M Keegan
Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
Cancer Epidemiol Biomarkers Prev 19:1208-18. 2010.... - Family history of breast cancer and all-cause mortality after breast cancer diagnosis in the Breast Cancer Family RegistryEllen T Chang
Northern California Cancer Center, Fremont, 94538, USA
Breast Cancer Res Treat 117:167-76. 2009..Therefore, clinical management should not depend on family history of breast cancer... - Phytoestrogen intake and endometrial cancer riskPamela L Horn-Ross
Northern California Cancer Center, Union City, CA 94587, USA
J Natl Cancer Inst 95:1158-64. 2003..We evaluated the associations between dietary intake of seven specific compounds representing three classes of phytoestrogens (isoflavones, coumestans, and lignans) and the risk of endometrial cancer... - Past recreational physical activity, body size, and all-cause mortality following breast cancer diagnosis: results from the Breast Cancer Family RegistryTheresa H M Keegan
Northern California Cancer Center, 2201 Walnut Ave, Suite 300, Fremont, CA 94536, USA
Breast Cancer Res Treat 123:531-42. 2010..90-2.15; HR for obese = 1.77, 95% CI: 1.11-2.82). BMI associations did not appear to differ by race/ethnicity. Our findings suggest that physical activity and BMI exert independent effects on overall mortality after breast cancer... - Lifetime physical activity and risk of endometrial cancerEsther M John
Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
Cancer Epidemiol Biomarkers Prev 19:1276-83. 2010..The role of moderate physical activity and life patterns of activity in reducing endometrial cancer risk remains uncertain... - Residential sunlight exposure is associated with a decreased risk of prostate cancerEsther M John
Northern California Cancer Center, Union City, CA 94587, USA
J Steroid Biochem Mol Biol 89:549-52. 2004..These data support the hypothesis that sunlight exposure reduces the risk of prostate cancer and have important implications for prostate cancer prevention... - Availability and accuracy of medical record information on language usage of cancer patients from a multi-ethnic populationLaura A McClure
Northern California Cancer Center, 2201 Walnut Avenue, Fremont, CA 94538, USA
J Immigr Minor Health 12:480-8. 2010..However, for the data to be useful for research and reducing language barriers in medical care, the information must be collected in a consistent and accurate manner... - Genetic ancestry and risk factors for breast cancer among Latinas in the San Francisco Bay AreaElad Ziv
Division of General Internal Medicine, University of California San Francisco, Box 1732, San Francisco, CA 94143, USA
Cancer Epidemiol Biomarkers Prev 15:1878-85. 2006..We reasoned that if genetic ancestry is associated with known breast cancer risk factors, then the results of genetic association studies would be confounded... - Dietary fat, cooking fat, and breast cancer risk in a multiethnic populationJun Wang
Department of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
Nutr Cancer 60:492-504. 2008..Our results suggest that a low-fat diet may play a role in breast cancer prevention. We speculate that monounsaturated trans fats may have driven the discrepant associations between types of fat and breast cancer... - Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American womenWei Wang
USC Norris Comprehensive Cancer Center, University of Southern California, Room 6419, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 14:2990-4. 2005..Our data, however, are unable to provide evidence that PSA is the pathway through which the protective effect of androgens operates... - An inverse association between ovarian cysts and breast cancer in the breast cancer family registryJulia A Knight
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Int J Cancer 118:197-202. 2006..Further study of ovarian cysts may increase our understanding of hormonal and other mechanisms of breast cancer etiology... - BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50Robert W Haile
Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice... - Obesity before age 30 years and risk of advanced prostate cancerWhitney R Robinson
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Am J Epidemiol 161:1107-14. 2005.... - Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutationsRoger L Milne
Centre for Genetic Epidemiology, The University of Melbourne, Level 2, 723 Swanston Street, Carlton, Victoria 3053, Australia
Cancer Epidemiol Biomarkers Prev 14:350-6. 2005..Recent oral contraceptive use has been associated with a small increase in breast cancer risk and a substantial decrease in ovarian cancer risk. The effects on risks for women with germ line mutations in BRCA1 or BRCA2 are unclear... - Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic WhitesAlice S Whittemore
Department of Health Research and Policy, Stanford University School of Medicine, Redwood Building, Room T204, Stanford, CA 94503 5405, USA
Cancer Epidemiol Biomarkers Prev 13:2078-83. 2004..S. Whites (506,206 non-Ashkenazim and 44,307 Ashkenazim) carry germ line BRCA1 mutations. These estimates may be useful in guiding resource allocation for genetic testing and genetic counseling and in planning preventive interventions... - Segregation analysis of prostate cancer in 1,719 white, African-American and Asian-American families in the United States and CanadaGail Gong
Stanford University School of Medicine, Department of Health Research and Policy, CA 94305-5405, USA
Cancer Causes Control 13:471-82. 2002.... - Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American womenVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Cancer Genet Cytogenet 181:16-9. 2008..18, 95% CI = 0.76-1.82, P = 0.46). Our results do not support the hypothesis that the mtDNA G10398A polymorphism is, as has previously been reported, a marker of breast cancer risk in African Americans... - The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriersAmanda B Spurdle
The Queensland Institute of Medical Research, Brisbane, Australia
Cancer Epidemiol Biomarkers Prev 15:76-9. 2006..Given the large sample size, with more than adequate power to detect previously reported effects, we conclude that the AIB1 glutamine repeat does not substantially modify risk of breast cancer in BRCA1 and BRCA2 mutation carriers... - The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family RegistryJonine L Bernstein
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 3rd Floor, 307 East 63rd Street, New York, New York 10021, USA
Cancer Epidemiol Biomarkers Prev 15:348-52. 2006..63; 95% CI, 1.25-10.52). These data supporting the biological relevance of CHEK2 in breast carcinogenesis suggest that further studies examining the joint roles of CHEK2*1100delC carrier status and radiation exposure may be warranted... - BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarraysAnita L Bane
Department of Pathology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada
Am J Surg Pathol 31:121-8. 2007.... - Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family RegistryMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 724, New York, NY 10032, USA
Breast Cancer Res Treat 106:281-8. 2007..However, only 19% and 42% of sisters were discordant by ADH1B and ADH1C, respectively, and even fewer were discordant by both genotype and alcohol intake, making it difficult to detect differences if they existed... - Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American menMatthew L Freedman
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:14068-73. 2006..Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it... - Multiple regions within 8q24 independently affect risk for prostate cancerChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Nat Genet 39:638-44. 2007..None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein... - A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African AmericansChristopher A Haiman
Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Cancer Res 67:3565-8. 2007..03) and stronger in those with advanced disease (411 cases and 877 controls; OR, 2.60; 95% CI, 1.56-4.34; P = 0.0002). These data suggest that African Americans harbor an allele at the POR locus that may increase breast cancer risk... - UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of womenAndrew L Hong
Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
Drug Metab Dispos 35:1254-61. 2007..These data have implications for the design of epidemiologic studies of cancer susceptibility and pharmacogenetic studies for adverse drug reactions in populations of African ancestry... - Breast and ovarian cancer in relatives of cancer patients, with and without BRCA mutationsJennifer S Lee
Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, Stanford, California 94305 5405, USA
Cancer Epidemiol Biomarkers Prev 15:359-63. 2006..Little is known about how their risks vary with the patient's cancer site, carrier status for predisposing genetic mutations, or age at cancer diagnosis... - Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descentChad P Garner
Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA, 92697 7550, USA
Hum Genet 123:247-55. 2008..0038 and P = 0.01 in African-Americans and Nigerians, respectively. This study is the first to report associations between genetic variants in IGFBP2 and IGFBP5 and breast cancer risk... - No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 yearsValerie McGuire
Department of Health Research and Policy, Stanford University School of Medicine, Health Research and Stanford, CA 94305-5405, USA
Cancer Epidemiol Biomarkers Prev 15:1565-7. 2006
Research Grants
- Body size and breast cancer risk in a multiethnic populationEsther John; Fiscal Year: 2007..This study will make an important contribution towards a better understanding of breast cancer etiology, and the role of body size in particular, in understudied populations such as African-Americans and Hispanics. ..