Paul J Kammermeier

Summary

Affiliation: Northeastern Ohio Universities College of Medicine
Country: USA

Publications

  1. ncbi Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins
    Paul J Kammermeier
    Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    BMC Neurosci 7:1. 2006
  2. ncbi Specificity of metabotropic glutamate receptor 2 coupling to G proteins
    Paul J Kammermeier
    Laboratory of Molecular Physiology, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland, USA
    Mol Pharmacol 63:183-91. 2003
  3. ncbi Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits
    Paul J Kammermeier
    Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P O Box 95, Rootstown, OH 44272, USA
    J Pharmacol Exp Ther 312:502-8. 2005
  4. ncbi G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells
    Liantian Tian
    Department of Biomedical Sciences, Kent State University, Rootstown, Ohio, USA
    Vis Neurosci 23:909-16. 2006
  5. ncbi Desensitization of group I metabotropic glutamate receptors in rat sympathetic neurons
    Paul J Kammermeier
    Laboratory of Molecular Physiology, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Neurophysiol 87:1669-76. 2002
  6. ncbi Metabotropic glutamate receptor expression in the rat superior cervical ganglion
    Paul J Kammermeier
    Laboratory of Molecular Physiology, Guthrie Research Institute, Sayre, PA 18840, USA
    Neurosci Lett 330:260-4. 2002
  7. ncbi M current mystery messenger revealed?
    Stephen R Ikeda
    Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 35:411-2. 2002
  8. ncbi Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:6055-60. 2007
  9. ncbi The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Eur J Pharmacol 589:49-52. 2008
  10. ncbi Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:8560-7. 2008

Collaborators

Detail Information

Publications10

  1. ncbi Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins
    Paul J Kammermeier
    Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    BMC Neurosci 7:1. 2006
    ..Further, an exhaustive study of the effects of each long Homer isoform on mGluR distribution has not been published...
  2. ncbi Specificity of metabotropic glutamate receptor 2 coupling to G proteins
    Paul J Kammermeier
    Laboratory of Molecular Physiology, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland, USA
    Mol Pharmacol 63:183-91. 2003
    ..Strong bands were detected for all members of the G(i/o) family (Galphao, Galphai1, Galphai2, Galphai3, Galphaz) as well as for Galpha11 and Galphas. A weak signal was detected for Galphaq and no Galpha15 mRNA was detected...
  3. ncbi Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits
    Paul J Kammermeier
    Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P O Box 95, Rootstown, OH 44272, USA
    J Pharmacol Exp Ther 312:502-8. 2005
    ..These data suggest that mutant/wild-type heterodimeric receptors are inactive at ligand concentrations favoring glutamate association with receptor dimers at only one subunit...
  4. ncbi G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells
    Liantian Tian
    Department of Biomedical Sciences, Kent State University, Rootstown, Ohio, USA
    Vis Neurosci 23:909-16. 2006
    ..Together, these data indicate that signaling through mGluR6 in mammalian ON bipolar cells is highly focused, apparently acting through a single G alpha protein subtype...
  5. ncbi Desensitization of group I metabotropic glutamate receptors in rat sympathetic neurons
    Paul J Kammermeier
    Laboratory of Molecular Physiology, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Neurophysiol 87:1669-76. 2002
    ..These data indicate a role for nonconventional protein kinase C isoforms as a mediator of mGluR5 desensitization and that the phosphorylation of mGluR5a that competes with calmodulin binding does not mediate desensitization...
  6. ncbi Metabotropic glutamate receptor expression in the rat superior cervical ganglion
    Paul J Kammermeier
    Laboratory of Molecular Physiology, Guthrie Research Institute, Sayre, PA 18840, USA
    Neurosci Lett 330:260-4. 2002
    ....
  7. ncbi M current mystery messenger revealed?
    Stephen R Ikeda
    Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 35:411-2. 2002
    ..These data suggest that breakdown of phosphotidylinositol 4,5-bisphosphate (PIP(2)) is a crucial determinant of M channel modulation...
  8. ncbi Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:6055-60. 2007
    ..Thus, alteration of mGluR signaling by changes in Homer protein expression may represent a viable mechanism for fine-tuning synaptic strength in neurons...
  9. ncbi The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Eur J Pharmacol 589:49-52. 2008
    ..Conversely, PHCCC directly activates the mGlu(6) receptor and does not enhance activity of glutamate. Therefore, PHCCC is a direct mGlu(6) receptor agonist, but lacks allosteric modulatory properties...
  10. ncbi Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:8560-7. 2008
    ..In both cases, RNA silencing of Homer 1a but not control RNA interference treatment prevented the PACAP effect, suggesting that it resulted specifically from native Homer 1a expression...