SCOTT DAVID MCCULLOCHSummaryAffiliation: North Carolina State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesScott D McCulloch
Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, NC 27695, USA
Cell Res 18:148-61. 2008....- Effects of accessory proteins on the bypass of a cis-syn thymine-thymine dimer by Saccharomyces cerevisiae DNA polymerase etaScott D McCulloch
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Biochemistry 46:8888-96. 2007..Thus, although accessory proteins clearly participate in pol eta functions in vivo, they do not appear to help suppress UV mutagenesis by improving pol eta bypass fidelity per se... - Multiple solutions to inefficient lesion bypass by T7 DNA polymeraseScott D McCulloch
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
DNA Repair (Amst) 5:1373-83. 2006.... - Measuring the fidelity of translesion DNA synthesisScott D McCulloch
Laboratory for Molecular Genetics, NIEHS-NIH, North Carolina, USA
Methods Enzymol 408:341-55. 2006..The assay can be used with other lesions in various sequence contexts and with other polymerases with or without accessory proteins... - Enzymatic switching for efficient and accurate translesion DNA replicationScott D McCulloch
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
Nucleic Acids Res 32:4665-75. 2004.... - Efficiency, fidelity and enzymatic switching during translesion DNA synthesisScott D McCulloch
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA
Cell Cycle 3:580-3. 2004..Several observations from that study were unanticipated. Here we discuss the structural and biological implications of those results in light of earlier studies of translesion synthesis... - Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelityScott D McCulloch
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA
Nature 428:97-100. 2004..Thus, in normal people and particularly in individuals with NER-defective xeroderma pigmentosum who accumulate dimers, errors made by Pol eta during dimer bypass could contribute to mutagenesis and skin cancer... - The efficiency and specificity of apurinic/apyrimidinic site bypass by human DNA polymerase eta and Sulfolobus solfataricus Dpo4Robert J Kokoska
Laboratories of Molecular Genetics and Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 278:50537-45. 2003.... - Nick-dependent and -independent processing of large DNA loops in human cellsScott D McCulloch
Graduate Center for Toxicology, Lucille P. Markey Cancer Center, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
J Biol Chem 278:50803-9. 2003..In addition, our data also suggest that an aphidicolin-sensitive DNA polymerase is involved in the excision step of the nick-directed loop repair pathway... - Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase etaEitan Glick
The Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195 357705, USA
J Biol Chem 278:19341-6. 2003.... - Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasiaMin Wang
Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cancer Res 64:1924-31. 2004..Thus, our data support the Pol iota gene as a modifier of lung tumorigenesis by altering DNA polymerase activity... - Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient miceQingcong Lin
Harvard Medical School Partners Healthcare Center for Genetics and Genomics, Boston, MA 02115, USA
Cancer Res 66:87-94. 2006..5% of pol eta heterozygous mice also developed skin cancer during 5 months after a 5-month exposure to UV light, suggesting that humans who are heterozygous for mutations in pol eta may also have an increased risk of skin cancer... - Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalphaFlavia Barone
Unit of Experimental Carcinogenesis, Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
DNA Repair (Amst) 6:355-66. 2007..MutSalpha also recognized 2-OH-A located in a repeat sequence that mimics a frameshift intermediate... - Mutator alleles of yeast DNA polymerase zetaAyako N Sakamoto
Research Group for Gene Resources, Department of Ion Beam Applied Biology, Japan Atomic Energy Agency, Watanuki machi 1233, Takasaki, Gunma 370 1292, Japan
DNA Repair (Amst) 6:1829-38. 2007..Reduced fidelity with retention of robust polymerase activity suggests that the homologous rev3-L979F allele may be useful for analyzing pol zeta functions in mammals, where REV3 deletion is lethal... - Bi-directional processing of DNA loops by mismatch repair-dependent and -independent pathways in human cellsScott D McCulloch
Graduate Center for Toxicology, University of Kentucky Medical Center, Lexington 40536, USA
J Biol Chem 278:3891-6. 2003..e. excision is conducted by exonucleases from the pre-existing strand break to the heterology), the processing of the heterology in substrates with a 3' strand break is consistent with the involvement of endonucleases...
Research Grants
- The role of human DNA polymerase eta in the mutagenic response to oxidative stresSCOTT MCCULLOCH; Fiscal Year: 2009..This will help us better understand specifically how exposure to such chemicals affects human health, and possibly to predict the affects of other agents that also cause oxidative stress. ..
- The role of human DNA polymerase eta in the mutagenic response to oxidative stresSCOTT DAVID MCCULLOCH; Fiscal Year: 2010..This will help us better understand specifically how exposure to such chemicals affects human health, and possibly to predict the affects of other agents that also cause oxidative stress. ..