Butch KuKanich

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi The disposition and behavioral effects of methadone in Greyhounds
    Butch KuKanich
    PharmCATS and Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66505 5802, USA
    Vet Anaesth Analg 35:242-8. 2008
  2. ncbi Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs
    B Kukanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Vet Pharmacol Ther 27:239-46. 2004
  3. ncbi Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs
    B Kukanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Vet Pharmacol Ther 27:337-41. 2004
  4. ncbi Validation of a high-pressure liquid chromatography and fluorescence polarization immunoassay for the determination of methadone in canine plasma
    Butch KuKanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Ther Drug Monit 27:389-92. 2005
  5. ncbi Use of a von Frey device for evaluation of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs
    Butch KuKanich
    Department of Molecular Biomedical Sciences, Pharmacology and Comparative Pain Research Laboratories, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Vet Res 66:1968-74. 2005
  6. ncbi Pharmacokinetics of oral gabapentin alone or co-administered with meloxicam in ruminant beef calves
    Johann F Coetzee
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506 5601, USA
    Vet J 190:98-102. 2011
  7. ncbi Effects of ketoconazole on the pharmacokinetics and pharmacodynamics of morphine in healthy Greyhounds
    Butch KuKanich
    Department of Anatomy and Physiology, and Pharmacology, Clinical, Analytical and Toxicological Services PharmCATS, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 69:664-9. 2008
  8. ncbi Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves followi
    Sarah L Baldridge
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 72:1305-17. 2011
  9. ncbi Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals
    Butch KuKanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 230:390-5. 2007
  10. ncbi Pharmacokinetics and antinociceptive effects of oral tramadol hydrochloride administration in Greyhounds
    Butch KuKanich
    Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 72:256-62. 2011

Collaborators

Detail Information

Publications20

  1. ncbi The disposition and behavioral effects of methadone in Greyhounds
    Butch KuKanich
    PharmCATS and Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66505 5802, USA
    Vet Anaesth Analg 35:242-8. 2008
    ..To determine the behavioral effects and pharmacokinetics of methadone in healthy Greyhounds...
  2. ncbi Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs
    B Kukanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Vet Pharmacol Ther 27:239-46. 2004
    ..5 mg/kg every 4 h predict tramadol and M1 plasma concentrations consistent with analgesia in humans; however, studies are needed to establish the safety and efficacy of these doses...
  3. ncbi Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs
    B Kukanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Vet Pharmacol Ther 27:337-41. 2004
    ..The short half-life, rapid clearance, and poor bioavailability of dextromethorphan limit its potential use as a chronic orally administered therapeutic...
  4. ncbi Validation of a high-pressure liquid chromatography and fluorescence polarization immunoassay for the determination of methadone in canine plasma
    Butch KuKanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Ther Drug Monit 27:389-92. 2005
    ..94 when plasma from dogs dosed with methadone was evaluated. FPIA provides a rapid, sensitive, and specific measurement of methadone in canine plasma following oral and intravenous administration...
  5. ncbi Use of a von Frey device for evaluation of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs
    Butch KuKanich
    Department of Molecular Biomedical Sciences, Pharmacology and Comparative Pain Research Laboratories, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Vet Res 66:1968-74. 2005
    ..CONCLUSIONS AND CLINICAL RELEVANCE: Morphine administered via IV infusion (0.15 +/- 0.02 mg/kg/h) and multiple doses (0.5 mg/kg, IV, every 2 hours for 3 doses) maintained significant antinociception in dogs...
  6. ncbi Pharmacokinetics of oral gabapentin alone or co-administered with meloxicam in ruminant beef calves
    Johann F Coetzee
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506 5601, USA
    Vet J 190:98-102. 2011
    ..2?g/mL for up to 48h. The pharmacokinetic profile of oral gabapentin and meloxicam supported clinical evaluation of these compounds for management of neuropathic pain in cattle...
  7. ncbi Effects of ketoconazole on the pharmacokinetics and pharmacodynamics of morphine in healthy Greyhounds
    Butch KuKanich
    Department of Anatomy and Physiology, and Pharmacology, Clinical, Analytical and Toxicological Services PharmCATS, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 69:664-9. 2008
    ..To assess pharmacokinetics and pharmacodynamics of morphine and the effects of ketoconazole on the pharmacokinetics and pharmacodynamics of morphine in healthy Greyhounds...
  8. ncbi Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves followi
    Sarah L Baldridge
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 72:1305-17. 2011
    ....
  9. ncbi Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals
    Butch KuKanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 230:390-5. 2007
    ..3 mg/lb) and to compare pharmacokinetic variables after pharmacokinetic analysis by naïve averaged, naïve pooled, and nonlinear mixed-effects modeling...
  10. ncbi Pharmacokinetics and antinociceptive effects of oral tramadol hydrochloride administration in Greyhounds
    Butch KuKanich
    Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 72:256-62. 2011
    ....
  11. ncbi Pharmacokinetics of oral gabapentin in greyhound dogs
    Butch KuKanich
    Kansas State University, College of Veterinary Medicine, Department of Anatomy and Physiology, 228 Coles Hall, Manhattan, KS 66506, USA
    Vet J 187:133-5. 2011
    ..13 compared to the 20mg/kg group. Gabapentin was rapidly absorbed and eliminated in dogs, indicating that frequent dosing is needed to maintain minimum targeted plasma concentrations...
  12. ncbi Clinical interpretation of pharmacokinetic and pharmacodynamic data in zoologic companion animal species
    Butch KuKanich
    College of Veterinary Medicine, Kansas State University, 228 Coles Hall, Manhattan, KS 66506 5802, USA
    Vet Clin North Am Exot Anim Pract 14:1-20. 2011
    ..The usefulness and limitations as well as considerations for interpreting PK, PD, and controlled clinical studies are discussed. An example of allometric analysis of buprenorphine in mammals is also included...
  13. ncbi The effects of concurrent administration of cytochrome P-450 inhibitors on the pharmacokinetics of oral methadone in healthy dogs
    Butch KuKanich
    Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Vet Anaesth Analg 38:224-30. 2011
    ..The objective was to examine the effects of inhibiting cytochrome P450 (CYP) on the pharmacokinetics of oral methadone in dogs...
  14. ncbi Pharmacokinetics and pharmacodynamics of dexamethasone after oral administration in apparently healthy horses
    Jason A Grady
    Veterinary Medical Teaching Hospital, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Am J Vet Res 71:831-9. 2010
    ..To assess pharmacokinetic and pharmacodynamic properties of dexamethasone administered PO as a solution or powder, compared with properties of dexamethasone solution administered IV, in apparently healthy horses...
  15. ncbi Assessment of a von Frey device for evaluation of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs
    Butch KuKanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Vet Res 66:1616-22. 2005
    ..CONCLUSIONS AND CLINICAL RELEVANCE: Data suggest that, in dogs, evaluation of the antinociceptive effect and pharmacodynamic modeling of a dose of morphine sulfate (1 mg/kg, i.v.) can be successfully achieved by use of a von Frey device...
  16. ncbi Analysis of weight uniformity, content uniformity and 30-day stability in halves and quarters of routinely prescribed cardiovascular medications
    Marco L Margiocco
    Department of Clinical Sciences, Kansas State University, College of Veterinary Medicine, Manhattan, KS 66506, USA
    J Vet Cardiol 11:31-9. 2009
    ..The aims of this study were to evaluate weight and content uniformity and 30-day chemical stability in halves and quarters of 11 drug formulations commonly prescribed to treat cardiovascular disorders in small breed dogs and cats...
  17. ncbi Pharmacokinetics of hydromorphone hydrochloride in healthy dogs
    Butch KuKanich
    PharmCATS and the Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, USA
    Vet Anaesth Analg 35:256-64. 2008
    ..To assess the pharmacokinetics of hydromorphone administered intravenously (IV) or subcutaneously (SC) to dogs...
  18. ncbi Pharmacokinetics and pharmacodynamics of morphine in llamas
    Samantha R Uhrig
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 68:25-34. 2007
    ..To assess the pharmacokinetics and pharmacodynamics of morphine in llamas...
  19. ncbi Evaluation of the bioavailability and pharmacokinetics of two extended-release theophylline formulations in dogs
    Jonathan E Bach
    Denver Veterinary Specialists, 3695 Kipling St, Wheat Ridge, CO 80033, USA
    J Am Vet Med Assoc 224:1113-9. 2004
    ....
  20. ncbi The effect of lidocaine on postoperative jejunal motility in normal horses
    Melissa Milligan
    Department of Clinical Sciences, Analytical Pharmacology Laboratory, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA
    Vet Surg 36:214-20. 2007
    ....