Research Topics
| JASON HAUGHSummaryAffiliation: North Carolina State University Country: USA Publications
Research Grants
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Detail Information
Publications
A unified model for signal transduction reactions in cellular membranesJason M Haugh
Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695 7905 USA
Biophys J 82:591-604. 2002..Under these conditions, however, enhanced substrate delivery can result in a decrease in the average substrate concentration...- Analysis of reaction-diffusion systems with anomalous subdiffusionJason M Haugh
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA
Biophys J 97:435-42. 2009..In each case, there are only subtle differences between the two subdiffusion models, suggesting how measurements of mean-squared displacement versus time might generally inform models of reactive systems with partial diffusion control... - Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensingJason M Haugh
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
Biophys J 90:2297-308. 2006..A somewhat surprising finding was that extremely sharp PDGF gradients do not necessarily stimulate faster progression through the clot, because maintaining such a gradient through PDGF consumption is a potentially rate-limiting process... - Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonistsJason M Haugh
Department of Chemical Engineering North Carolina State University, Raleigh, North Carolina 27695 7905, USA
Biotechnol Prog 20:1337-44. 2004.... - Localization of receptor-mediated signal transduction pathways: the inside storyJason M Haugh
Department of Chemical Engineering, North Carolina State University, Raleigh, NC 27695 7905, USA
Mol Interv 2:292-307. 2002..Still, only when the effects of decreased receptor populations and signaling compartmentalization are integrated can we hope to understand and manipulate receptor function at the molecular level... - Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groupsJason M Haugh
Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
Biophys J 86:589-98. 2004..Based on our analysis, we expect that the key dimensionless group, the ratio of 3' PI turnover and diffusion rates, can be estimated within approximately 20% or less... - Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signalingJason M Haugh
Department of Chemical Engineering, North Carolina State University, Raleigh, NC 27695 7905, USA
J Cell Sci 115:303-10. 2002.... - Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experimentsIan C Schneider
Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
Biophys J 86:599-608. 2004..18 +/- 0.54 min(-1). In addition, we report that 3' PI turnover is not affected by PDGF receptor signaling in our cells, allowing us to focus our attention on the regulation of 3' PI production as this system is studied further... - Structure-based kinetic models of modular signaling protein function: focus on Shp2Dipak Barua
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
Biophys J 92:2290-300. 2007.... - Reactions on cell membranes: comparison of continuum theory and Brownian dynamics simulationsMichael I Monine
Department of Chemical and Biomolecular Engineering, North Carolina State University, Box 7905, 911 Partners Way, Raleigh, North Carolina 27695-7905, USA
J Chem Phys 123:074908. 2005..In all cases, we find the theory and simulations to be in quantitative agreement. This algorithm may be readily adapted for the stochastic simulation of more complex cell signaling systems... - Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblastsChang Shin Park
Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905, USA
J Biol Chem 278:37064-72. 2003..Thus, at high concentrations of PDGF the kinetics of 3'-PI production are limited by the turnover rate of these lipids, while the Akt response is additionally influenced by the rate of Akt deactivation... - Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblastsMichael C Weiger
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
J Cell Sci 122:313-23. 2009..These results underscore the importance of localized PI3K signaling not only in chemotaxis but also in basal motility/migration of fibroblasts... - A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinasesDipak Barua
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA
PLoS Comput Biol 5:e1000364. 2009..Analysis of the results revealed a unique mechanism whereby SH2-B and receptor dimers constitute a bipolar 'clamp' that stabilizes the active configuration of two Jak2 molecules in the same macro-complex... - Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblastsIan C Schneider
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
J Cell Biol 171:883-92. 2005.... - On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signalingJason M Haugh
Department of Chemical Engineering, 113 Riddick Lab, Box 7905, North Carolina State University, Raleigh, NC 27695 7905, USA
J Theor Biol 230:119-32. 2004.... - Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalkMichael I Monine
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
Biophys J 95:2172-82. 2008..We contend that this mechanism is a means by which signaling pathways are propagated and spatially coordinated for efficient crosstalk between them... - Directional persistence of cell migration coincides with stability of asymmetric intracellular signalingMichael C Weiger
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA
Biophys J 98:67-75. 2010..These results are indicative of a mechanism by which changes in a cell's direction of migration are determined by a fragile balance of relatively rapid intracellular signaling processes... - PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by ErkChun Chao Wang
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695 7905, USA
Mol Syst Biol 5:246. 2009..Motivated by those dynamics, a kinetic model of the network was formulated and used to precisely quantify the relative contributions of PI3K-dependent and -independent modes of Ras/Erk activation... - Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cellsMurat Cirit
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America
PLoS Comput Biol 6:e1000688. 2010.... - Mechanisms of gradient sensing and chemotaxis: conserved pathways, diverse regulationIan C Schneider
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
Cell Cycle 5:1130-4. 2006..The marked differences between this system and the others have led us to speculate on the diversity of gradient sensing mechanisms and their biological implications... - Spatial analysis of 3' phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological PolarityIan C Schneider
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, 27695, USA
Biophys J 89:1420-30. 2005..The morphological polarity of the cell may thus bias 3' PI signaling to promote persistent migration in fibroblasts... - Computational models of tandem SRC homology 2 domain interactions and application to phosphoinositide 3-kinaseDipak Barua
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
J Biol Chem 283:7338-45. 2008..Homodimerization of full-length p85 was found to be an alternative mechanism for high avidity binding to phosphorylated platelet-derived growth factor receptors, which would render the N-SH2 domain dispensable for receptor binding... - Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assemblyHarjeet Kaur
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA
Biochem J 393:235-43. 2006.... - Biophysics: cells get in shape for a crawlJason M Haugh
Nature 453:461-2. 2008 - Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphologyJason M Haugh
Biophys J 92:L93-5. 2007..Moreover, this model allows for amplification of the activated protein bound at the membrane, which is considered more relevant for certain, spatially driven signaling processes in cell migration...
Research Grants
- Molecular Crosstalk in Intracellular Signaling NetoworksJASON HAUGH; Fiscal Year: 2006..Finally, for conditions found to perturb the signaling network, the corresponding effects on cell proliferation and survival will be assessed. ..
- Signal Transduction in Models of Fibroblast InvasionJASON HAUGH; Fiscal Year: 2007..These efforts will serve as a foundation for more in-depth studies of molecular mechanisms governing physiological processes. ..
- Dynamic Regulation of Growth Factor Signaling NetworksJason M Haugh; Fiscal Year: 2010..By analyzing these mechanisms quantitatively and using mathematical models, we hope to be able to predict the outcomes of interventions targeting the molecular players in these pathways. ..