Research Topics
Genomes and Genes | James C BonnerSummaryAffiliation: North Carolina State University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Respiratory syncytial virus infection reduces lung inflammation and fibrosis in mice exposed to vanadium pentoxideElizabeth A Turpin
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Respir Res 11:20. 2010..It is unknown whether individuals with pre-existing respiratory viral infection are susceptible to V2O5-induced bronchitis. We hypothesized that respiratory viral infection will exacerbate vanadium-induced lung fibrosis...- Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?James C Bonner
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
Expert Rev Respir Med 5:779-87. 2011..However, functionalization of CNTs to modulate aspect ratio, biodegradability and to remove residual metals could allow for safe design of CNTs for use in drug delivery in certain circumstances... - Mesenchymal cell survival in airway and interstitial pulmonary fibrosisJames C Bonner
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
Fibrogenesis Tissue Repair 3:15. 2010..Understanding the mechanisms that regulate the survival or death of mesenchymal cells is central to ultimately developing therapeutic strategies for lung fibrosis... - Nanoparticles as a potential cause of pleural and interstitial lung diseaseJames C Bonner
Department of Environmental and Molecular Toxicology, Campus Box 7633, Raleigh, NC 27695 7633, USA
Proc Am Thorac Soc 7:138-41. 2010.... - Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesisDianne M Walters
CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, NC 27709, USA
Am J Pathol 167:1221-9. 2005.... - Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblastsJennifer L Ingram
CIIT Centers for Health Research, Research Triangle Park, Durham, NC 27709, USA
J Immunol 177:4141-8. 2006..This novel mechanism could aid in identifying molecular targets for the treatment of chronic airway remodeling and fibrosis in asthma... - IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-RalphaJennifer L Ingram
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 18:1132-4. 2004..Our findings indicate that IL-13 acts in synergy with IL-1beta to stimulate growth by coordinately up-regulating PDGF-AA and the PDGF-Ralpha, respectively... - STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loopAurita Antao-Menezes
Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
J Immunol 180:4200-7. 2008..This mechanism is postulated to counterbalance profibrogenic mechanisms that follow V(2)O(5) injury... - Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinaseYi-Zhe Wang
Laboratory of Pulmonary Pathobiology, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 35:845-55. 2003..Moreover, p38 MAPK and EGF receptor activation are required for V2O5-induced STAT-1 activation... - Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinasesJennifer L Ingram
Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Am J Physiol Lung Cell Mol Physiol 284:L774-82. 2003..The induction of HB-EGF is not related to a burst of H(2)O(2) in V(2)O(5) treated cells, yet the action of V(2)O(5) in upregulating HB-EGF is oxidant dependent and could be due to the reaction of V(2)O(5) with endogenous H(2)O(2)... - Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthmaJessica P Ryman-Rasmussen
North Carolina State University, Box 7633, Raleigh, NC 27695, USA
Am J Respir Cell Mol Biol 40:349-58. 2009..These data indicate that inhaled MWCNT require pre-existing inflammation to cause airway fibrosis. Our findings suggest that individuals with pre-existing allergic inflammation may be susceptible to airway fibrosis from inhaled MWCNT... - Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitisJennifer L Ingram
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Respir Res 8:34. 2007.... - Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosisJames W Voltz
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Am J Respir Cell Mol Biol 39:45-52. 2008..Sex differences should be carefully considered when designing and interpreting experimental models of pulmonary fibrosis in mice... - Regulation of PDGF and its receptors in fibrotic diseasesJames C Bonner
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Cytokine Growth Factor Rev 15:255-73. 2004..This review summarizes the literature on the role of PDGF and its receptors in the development of fibrosis in a variety of organ systems, including lung, liver, kidney, and skin... - Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthmaJennifer L Ingram
Laboratory of Pulmonary Pathobiology (Drs. Ingram and Bonner, Ms. Rice, and Ms. Geisenhoffer, National Institute of Environmental Health Science, Research Triangle Park, NC 27709, USA
Chest 123:422S-4S. 2003 - Lung fibrotic responses to particle exposureJames C Bonner
Respiratory Biology Program, Division of Biological Sciences, CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
Toxicol Pathol 35:148-53. 2007.... - Bacterial lipopolysaccharide enhances PDGF signaling and pulmonary fibrosis in rats exposed to carbon nanotubesMark F Cesta
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, 27695 7633, USA
Am J Respir Cell Mol Biol 43:142-51. 2010..Our findings also suggest that individuals with pre-existing pulmonary inflammation are at greater risk for the potential adverse effects of MWCNT... - EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseasesJennifer L Ingram
Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27709, USA
Curr Mol Med 6:409-21. 2006..A full understanding of the complex mechanisms involving these receptors and ligands should lead to therapeutic strategies for the treatment of a wide range of fibroproliferative lung diseases... - p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblastsAnnette B Rice
Airway Inflammation Group, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
Am J Respir Cell Mol Biol 27:759-65. 2002..Collectively, these data demonstrate that p38 MAP kinase activation negatively regulates PDGF- and EGF-mediated growth responses by directly interacting with ERK1/2 and suppressing its phosphorylation... - Inhaled carbon nanotubes reach the subpleural tissue in miceJessica P Ryman-Rasmussen
Department of Environmental and Molecular Toxicology, College of Agricultural and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA
Nat Nanotechnol 4:747-51. 2009..This work suggests that minimizing inhalation of nanotubes during handling is prudent until further long-term assessments are conducted... - Proliferation of the airway epithelium in asthma: are inflammatory cells required?Brian W Booth
North Carolina State University, Raleigh, NC 27606, USA
Chest 123:384S-5S. 2003 - Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesisJames C Bonner
Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
Am J Pathol 161:459-70. 2002..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...