Sanjay Chanda

Summary

Affiliation: Nonclinical Safety
Country: USA

Publications

  1. ncbi Developmental toxicity study of pure trans-capsaicin in rats and rabbits
    Sanjay Chanda
    NeurogesX, Inc, San Carlos, CA 94070, USA
    Int J Toxicol 25:205-17. 2006
  2. ncbi 26-Week dermal oncogenicity study evaluating pure trans-capsaicin in Tg.AC hemizygous mice (FBV/N)
    Sanjay Chanda
    NeurogesX, Inc San Carlos, California 94070, USA
    Int J Toxicol 26:123-33. 2007
  3. ncbi Genotoxicity studies with pure trans-capsaicin
    Sanjay Chanda
    NeurogesX Inc, Nonclinical Safety, 981F Industrial Road, San Carlos, CA 94070, USA
    Mutat Res 557:85-97. 2004
  4. ncbi Toxicity studies with pure trans-capsaicin delivered to dogs via intravenous administration
    Sanjay Chanda
    NeurogesX, Inc, 981F Industrial Road, San Carlos, CA 94070, USA
    Regul Toxicol Pharmacol 43:66-75. 2005
  5. ncbi In vitro hepatic and skin metabolism of capsaicin
    Sanjay Chanda
    NeurogesX, Inc, 2215 Bridgepointe Parkway, Suite 200, San Carlos, CA 94404, USA
    Drug Metab Dispos 36:670-5. 2008
  6. ncbi Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain
    Sunita Babbar
    NeurogesX, Inc, San Mateo, California 94404, USA
    Ther Drug Monit 31:502-10. 2009
  7. ncbi Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin
    Sunita Babbar
    NeurogesX Inc, 2215 Bridgepointe Parkway, San Mateo, CA 94404, USA
    Xenobiotica 40:807-16. 2010
  8. ncbi 17beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice
    Karen L Porter
    Cell Signaling and Cancer Group, Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, North Carolina 27695, USA
    Toxicol Sci 69:42-8. 2002

Collaborators

Detail Information

Publications8

  1. ncbi Developmental toxicity study of pure trans-capsaicin in rats and rabbits
    Sanjay Chanda
    NeurogesX, Inc, San Carlos, CA 94070, USA
    Int J Toxicol 25:205-17. 2006
    ..3 mg/cm(2)trans-capsaicin). Taken together, these data suggest that tran s-capsaicin should not be considered a developmental toxicant...
  2. ncbi 26-Week dermal oncogenicity study evaluating pure trans-capsaicin in Tg.AC hemizygous mice (FBV/N)
    Sanjay Chanda
    NeurogesX, Inc San Carlos, California 94070, USA
    Int J Toxicol 26:123-33. 2007
    ..Based on these results, trans-capsaicin, lidocaine, and DGME should be considered nononcogenic in the Tg.AC mouse dermal model...
  3. ncbi Genotoxicity studies with pure trans-capsaicin
    Sanjay Chanda
    NeurogesX Inc, Nonclinical Safety, 981F Industrial Road, San Carlos, CA 94070, USA
    Mutat Res 557:85-97. 2004
    ..Moreover, the different genotoxicity profiles of pure trans-capsaicin and purified chili pepper extracts suggest that the purity and source of capsaicin should always be an important consideration for toxicological evaluations...
  4. ncbi Toxicity studies with pure trans-capsaicin delivered to dogs via intravenous administration
    Sanjay Chanda
    NeurogesX, Inc, 981F Industrial Road, San Carlos, CA 94070, USA
    Regul Toxicol Pharmacol 43:66-75. 2005
    ..The different toxicity profiles of pure trans-capsaicin reported here and chili pepper extracts previously reported suggest that the purity and source of capsaicin should be an important consideration for toxicological evaluations...
  5. ncbi In vitro hepatic and skin metabolism of capsaicin
    Sanjay Chanda
    NeurogesX, Inc, 2215 Bridgepointe Parkway, Suite 200, San Carlos, CA 94404, USA
    Drug Metab Dispos 36:670-5. 2008
    ..These data suggest that the metabolism of capsaicin by cytochrome P450 enzymes in skin is minimal, relative to hepatic metabolism...
  6. ncbi Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain
    Sunita Babbar
    NeurogesX, Inc, San Mateo, California 94404, USA
    Ther Drug Monit 31:502-10. 2009
    ..The low systemic exposure and very rapid elimination half-life of capsaicin after NGX-4010 administration are unlikely to result in systemic effects and support the overall safety profile of this investigational cutaneous patch...
  7. ncbi Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin
    Sunita Babbar
    NeurogesX Inc, 2215 Bridgepointe Parkway, San Mateo, CA 94404, USA
    Xenobiotica 40:807-16. 2010
    ..1. Although pre-incubation did enhance the potency for CYP2B6 inhibition to 5.1 ?M, given that exposure to capsaicin from either food or a topical medicine is very low (?58?nM) and transient, effects on CYPs appear unlikely...
  8. ncbi 17beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice
    Karen L Porter
    Cell Signaling and Cancer Group, Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, North Carolina 27695, USA
    Toxicol Sci 69:42-8. 2002
    ..Collectively, these studies indicate that E2 is a major ovarian hormone responsible for mirex tumor promotion sensitivity in female mice...