Gail Zeevalk

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi Excitotoxicity and oxidative stress during inhibition of energy metabolism
    G D Zeevalk
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, N J, USA
    Dev Neurosci 20:444-53. 1998
  2. ncbi Glutathione and Parkinson's disease: is this the elephant in the room?
    Gail D Zeevalk
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, NJ 08854, USA
    Biomed Pharmacother 62:236-49. 2008
  3. ncbi Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease
    G D Zeevalk
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Building UBHC, Rm 405D, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Exp Neurol 203:512-20. 2007
  4. ncbi Mitochondrial inhibition and oxidative stress: reciprocating players in neurodegeneration
    G D Zeevalk
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:1117-39. 2005
  5. ncbi Energy status, ubiquitin proteasomal function, and oxidative stress during chronic and acute complex I inhibition with rotenone in mesencephalic cultures
    Gail D Zeevalk
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:662-72. 2005
  6. ncbi Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells
    Gail D Zeevalk
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neurochem Res 35:1575-87. 2010
  7. ncbi Lactate prevents the alterations in tissue amino acids, decline in ATP, and cell damage due to aglycemia in retina
    G D Zeevalk
    Department of Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    J Neurochem 75:1027-34. 2000
  8. ncbi Differential sensitivity of mesencephalic neurons to inhibition of phosphatase 2A
    G D Zeevalk
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, New Jersey 08854, USA
    J Pharmacol Exp Ther 298:925-33. 2001
  9. ncbi Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction
    Lisa M Domico
    Joint Graduate Program in Toxicology, Rutgers-The State University of New Jersey, and University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ, USA
    Neurotoxicology 27:816-25. 2006
  10. ncbi Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures
    Julie Ehrhart
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Neurochem 86:1487-97. 2003

Research Grants

  1. ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITY
    Gail Zeevalk; Fiscal Year: 2002
  2. ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITY
    Gail Zeevalk; Fiscal Year: 2007

Collaborators

Detail Information

Publications17

  1. ncbi Excitotoxicity and oxidative stress during inhibition of energy metabolism
    G D Zeevalk
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, N J, USA
    Dev Neurosci 20:444-53. 1998
    ....
  2. ncbi Glutathione and Parkinson's disease: is this the elephant in the room?
    Gail D Zeevalk
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, NJ 08854, USA
    Biomed Pharmacother 62:236-49. 2008
    ..Consideration of how the CNS generates and handles the substrates for GSH synthesis is also addressed with the view in mind that this may provide insights into control and maintenance of intracellular glutathione...
  3. ncbi Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease
    G D Zeevalk
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Building UBHC, Rm 405D, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Exp Neurol 203:512-20. 2007
    ....
  4. ncbi Mitochondrial inhibition and oxidative stress: reciprocating players in neurodegeneration
    G D Zeevalk
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:1117-39. 2005
    ..Recent evidence that links protein aggregation to oxidative stress and mitochondrial dysfunction will also be examined. Lastly, current therapies that target mitochondrial dysfunction or oxidative stress are discussed...
  5. ncbi Energy status, ubiquitin proteasomal function, and oxidative stress during chronic and acute complex I inhibition with rotenone in mesencephalic cultures
    Gail D Zeevalk
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:662-72. 2005
    ..High concentrations of rotenone that collapse energy status kill neurons in a nonselective manner independent of the ubiquitin proteasomal pathway...
  6. ncbi Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells
    Gail D Zeevalk
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neurochem Res 35:1575-87. 2010
    ..No toxicity was observed with the liposomal preparation at 200-fold the EC(50) for repletion. These findings indicate that glutathione supplied in a liposomal formulation holds promise as a potential therapeutic for neuronal maintenance...
  7. ncbi Lactate prevents the alterations in tissue amino acids, decline in ATP, and cell damage due to aglycemia in retina
    G D Zeevalk
    Department of Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    J Neurochem 75:1027-34. 2000
    ..The above findings show that lactate is readily utilized by the chick retina during glucose deprivation to prevent derangements in tissue amino acids and ATP and retinal neuronal cell death...
  8. ncbi Differential sensitivity of mesencephalic neurons to inhibition of phosphatase 2A
    G D Zeevalk
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway, New Jersey 08854, USA
    J Pharmacol Exp Ther 298:925-33. 2001
    ..Disturbances in the phosphorylation control of proteins unique to dopamine neurons may contribute to their enhanced vulnerability to OKA exposure...
  9. ncbi Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction
    Lisa M Domico
    Joint Graduate Program in Toxicology, Rutgers-The State University of New Jersey, and University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ, USA
    Neurotoxicology 27:816-25. 2006
    ..In conclusion, our findings indicate that acute exposure to high doses of MZ and MB produce equipotent toxic effects in both DA and GABA neurons that may be associated with perturbations in mitochondrial respiration...
  10. ncbi Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures
    Julie Ehrhart
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Neurochem 86:1487-97. 2003
    ..It is speculated that these events are linked by glutaredoxin, an enzyme shown to contain both dehydroascorbate reductase as well as glutathione thioltransferase activities...
  11. ncbi Protection of malonate-induced GABA but not dopamine loss by GABA transporter blockade in rat striatum
    Gail D Zeevalk
    Department of Neurology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Exp Neurol 176:193-202. 2002
    ..These findings also point to fundamental differences between immature and adult neurons in the downstream involvement of GABA receptors during metabolic insult...
  12. ncbi Functional glutaredoxin (thioltransferase) activity in rat brain and liver mitochondria
    Julie Ehrhart
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Building UBHC, Room D 437 E 675 Hoes Lane, Piscataway, NJ 08854, USA
    Parkinsonism Relat Disord 8:395-400. 2002
    ..The data presented demonstrate that mitochondria contain functional Grx-like activity...
  13. ncbi Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively
    Peter D Alfinito
    Levine Neuroscience Laboratory, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 23:10982-7. 2003
    ..Interestingly, these effects are mediated by A1 and A2a receptors located in the substantia nigra for DAergic neurons and in the striatum for GABAergic neurons...
  14. ncbi Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease
    Patricia K Sonsalla
    Department of Neurology, Robert Wood Johnson Medical School UMDNJ, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Parkinsonism Relat Disord 14:S116-8. 2008
    ..We review features of this model that include loss of nigral DA neurons, swollen and abnormal mitochondria, striatal inclusion-like bodies and microgliosis. Advantages as well as limitations of the model are addressed...
  15. ncbi Inhibition of brain mitochondrial respiration by dopamine: involvement of H(2)O(2) and hydroxyl radicals but not glutathione-protein-mixed disulfides
    Martin Gluck
    Department of Neurology, Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    J Neurochem 82:66-74. 2002
    ..The results show that DA-associated inhibition of respiration is dependent on MAO and that H(2) O(2) and its downstream hydroxyl radical rather than increased GSSG and subsequent PrSSG formation mediate the effects...
  16. ncbi Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells
    Lisa M Domico
    Joint Graduate Program in Toxicology, Rutgers The State University of New Jersey, Piscataway, NJ, USA
    Neurotoxicology 28:1079-91. 2007
    ..The findings further show that microglia may contribute to but are not required for ROS production by MZ...
  17. ncbi Inhibition of brain mitochondrial respiration by dopamine and its metabolites: implications for Parkinson's disease and catecholamine-associated diseases
    Martin R Gluck
    Department of Neurology, Bronx Veterans Medical Center, Bronx, New York, USA
    J Neurochem 91:788-95. 2004
    ..In summary, mitochondrial respiration can be inhibited by DA and its metabolites by four distinct MAO-dependent and independent mechanisms...

Research Grants8

  1. ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITY
    Gail Zeevalk; Fiscal Year: 2002
    ....
  2. ENERGY METABOLISM, DOPAMINE NEURONS AND NEUROTOXICITY
    Gail Zeevalk; Fiscal Year: 2007
    ..The studies will have relevance to neurodegenerative conditions or pathophysiological situations in which metabolism is compromised. ..