Research Topics
Species | H L WeinerSummaryAffiliation: New York University Country: USA Publications
Research Grants
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Detail Information
Publications
Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumorsH L Weiner
Division of Pediatric Neurosurgery, New York University School of Medicine, New York 10016, USA
Neurosurgery 47:1400-9. 2000..Here, we analyze the cellular origin and distribution of DDR1 expression in human brain tumors and its expression in tumor cells relative to surrounding brain...- Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsyJoel A Bauman
New York University Comprehensive Epilepsy Center, and Department of Neurology, New York University Medical Center, New York, New York, USA
Neurosurgery 56:318-34. 2005..Our results, however, support the contention that multistage epilepsy surgery is safe, effective, and useful in a challenging and select pediatric population with extratemporal medically refractory epilepsy... - Tuberous sclerosis and multiple tubers: localizing the epileptogenic zoneHoward L Weiner
Division of Pediatric Neurosurgery, Department of Neurosurgery, Comprehensive Epilepsy Center, New York University Medical Center, New York, New York 10016, USA
Epilepsia 45:41-2. 2004..Long-term follow-up will determine whether this approach has durable effects. We await better methods for identifying the epileptogenic zone, both noninvasive and invasive... - Epilepsy surgery for children with tuberous sclerosis complexHoward L Weiner
Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University Medical Center, New York, NY 10016, USA
J Child Neurol 19:687-9. 2004..Long-term follow-up will determine whether this approach has durable effects. We await better methods for identifying the epileptogenic zone, both noninvasive and invasive... - Epilepsy surgery in young children with tuberous sclerosis: results of a novel approachHoward L Weiner
Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University Medical Center, New York, New York 10016, USA
Pediatrics 117:1494-502. 2006..To identify patients who might benefit from surgery and to maximize outcome, we used a novel surgical approach in young children that consists of invasive intracranial monitoring, which is typically 3-staged and often bilateral... - Delayed surgical resection of central nervous system germ cell tumorsHoward L Weiner
Department of Neurosurgery, New York University Medical Center, New York Presbyterian Hospital, New York, New York 10016, USA
Neurosurgery 50:727-33; discussion 733-4. 2002.... - Intrathecal baclofen in X-linked adrenoleukodystrophyM L Chu
The Center for Children, Hospital for Joint Diseases and New York University Hospitals Center, New York, NY 10003, USA
Pediatr Neurol 24:156-8. 2001.... - Comparison of frameless stereotactic systems: accuracy, precision, and applicationsE A Benardete
Department of Neurosurgery, New York University Medical Center, New York, New York 10016, USA
Neurosurgery 49:1409-15; discussion 1415-6. 2001..Each system uses a different method of spatial localization, i.e., mechanical linkage (ISG system), magnetic field digitization (Cygnus system), or optical technology (SMN system)... - Bilateral resective epilepsy surgery in a child with tuberous sclerosis: case reportP Romanelli
Department of Neurosurgery, New York University-Mount Sinai Comprehensive Epilepsy Center, New York University Medical Center, New York 10016, USA
Neurosurgery 49:732-4; discussion 735. 2001..CONCLUSION: In selected patients with bilateral seizure foci involving separate lobes, aggressive bilateral surgery can be safe and effective... - Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcomeH L Weiner
Department of Neurosurgery, New York University Medical Center, New York
Neurosurgery 35:1001-10; discussion 1010-1. 1994..3) Contrary to prior hypotheses, brain invasion in totally resected tumors does not predict higher recurrence. 4) GTR is associated with a significantly lower recurrence rate and can be achieved without sacrificing functional outcome... - Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: from the First International CNS Germ-Cell Tumor StudyS A Sands
Department of Psychiatry, New York University School of Medicine, NY 10016, USA
Neuro Oncol 3:174-83. 2001.... - Subfascial implantation of intrathecal baclofen pumps in children: technical noteB H Kopell
Department of Neurosurgery, New York University School of Medicine, New York 10016, USA
Neurosurgery 49:753-6; discussion 756-7. 2001..CONCLUSION: At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases... - Transient syringomyelia leading to acute neurological deterioration after repair of a lipomyelomeningocele: case reportNicholas H Post
Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University School of Medicine, New York, New York, USA
Neurosurgery 61:E426; discussion E426. 2007..We present the unique case of a patient who developed transient paraplegia 48 hours after lipomyelomeningocele repair attributable to the acute development of a thoracic syrinx... - Local epileptogenic networks in tuberous sclerosis complex: a case reviewDeepak Madhavan
New York University Comprehensive Epilepsy Center, 403 East 34th Street, Fourth Floor, New York, NY 10016, USA
Epilepsy Behav 11:140-6. 2007..This article describes three patients with TSC who underwent three-stage epilepsy surgery at our center, with the intention of examining local electrophysiological changes after each stage of the procedure... - Surgical outcome in tuberous sclerosis complex: a multicenter surveyDeepak Madhavan
Comprehensive Epilepsy Center, Department of Neurology, NYU Medical Center, 403 East 34th Street, New York, NY 10016, U S A
Epilepsia 48:1625-8. 2007..01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant... - Developmental outcome of epilepsy surgery in tuberous sclerosis complexCharles M Zaroff
Clinical Neuropsychology, NYU Comprehensive Epilepsy Center, New York 10016, USA
Epileptic Disord 7:321-6. 2005..Age estimates of developmental level indicated developmental progress in the majority of subjects in the current sample, and may yield greater clinical information for individuals with developmental delay than do standard scores... - Tuberous sclerosis: a primary pathology of astrocytes?Alexander A Sosunov
Neurological Surgery, Columbia University, New York, New York 10032, USA
Epilepsia 49:53-62. 2008..We hypothesize that the development of astrogliosis in cortical tubers constitutes a primary pathology of astrocytes and is directly related to TSC 1/2 mutations... - Markers of cellular proliferation are expressed in cortical tubersAllana Lee
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Ann Neurol 53:668-73. 2003..Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may share a common cellular lineage. Tubers may contain a subpopulation of newly generated cells... - Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complexIngeborg Fischer
Department of Pathology, New York University School of Medicine, New York, NY, USA
Acta Neuropathol 116:67-77. 2008..Genomic analysis with SNP arrays revealed copy number changes which may be associated with the pathogenesis of such infiltrates... - Hung span method of scaphocephaly reconstruction in patients with elevated intracranial pressureJoseph G McCarthy
Institute of Plastic and Reconstructive Surgery and the Department of Neurosurgery, New York University Medical Center, New York, NY, USA
Plast Reconstr Surg 109:2009-18. 2002 - Epilepsy surgery in tuberous sclerosis: multistage procedures with bilateral or multilobar fociPantaleo Romanelli
Department of Neurosurgery, Stanford University Medical Center, California, USA
J Child Neurol 17:689-92. 2002..This multistage approach permitted resection of epileptogenic foci that would traditionally have been considered inoperable... - Membrane bound IL-15 is increased on CD14 monocytes in early stages of MSAdi Vaknin-Dembinsky
Center for Neurological Diseases, Brigham and Women s Hospital, Harvard Medical, School, Boston Massachusetts 02115, United States
J Neuroimmunol 195:135-9. 2008..Thus, IL-15 may be an important cytokine that drives Th1 responses early in the course of the disease and could serve as a target for immunotherapy and as an early marker in the immunologic staging of MS... - MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervalsFrancois Cotton
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Neurology 60:640-6. 2003..Early lesion growth parameters may predict final lesion size. Within-patient heterogeneity of lesion evolution suggests that individual lesions develop independently... - The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in miceHelmut Hopfer
Program in Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Dana 514, Boston Massachusetts 02215, USA
FASEB J 17:860-8. 2003..Our in vivo and in vitro results provide direct evidence that the balance between Th1 and Th2 responses associates with the outcome of anti-GBM disease in mice... - Immunosuppressive treatment in multiple sclerosisHoward L Weiner
Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
J Neurol Sci 223:1-11. 2004..Cyclophosphamide and mitoxantrone are the most common immunosuppressive drugs used in patients with rapidly worsening MS whose disease is not controlled by beta-interferon or glatiramer acetate... - Tuberous sclerosis complex: molecular pathogenesis and animal modelsLeandro R Piedimonte
Division of Pediatric Neurosurgery, Department of Neurosurgery, New York University School of Medicine, New York, New York 10016, USA
Neurosurg Focus 20:E4. 2006..In the future, these animals will be invaluable preclinical models for the development of highly specific and efficacious treatments for children affected with TSC... - Temozolomide is active in childhood, progressive, unresectable, low-grade gliomasDennis J Kuo
Department of Pediatrics, New York University, New York, USA
J Pediatr Hematol Oncol 25:372-8. 2003..It is effective in previously treated patients and in patients with neurofibromatosis type 1. The 42-day regimen appears less toxic than the 5-day regimen. Any impact on survival for these patients remains to be demonstrated... - Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic strokeDan Frenkel
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Neurol Sci 233:125-32. 2005..Based on these results, modulation of cerebral inflammation by mucosal tolerance to myelin antigens may have applicability both as prophylactic therapy and treatment following ischemia attacks... - Immunotherapeutic approaches to Alzheimer's diseaseAlon Monsonego
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 302:834-8. 2003..We will also discuss how these approaches affect microglia activation, which plays a key role in therapy of such diseases... - Skull deformitiesEmily B Ridgway
Department of Neurological Surgery, New York University School of Medicine, 317 East 34 th Street, New York, NY 10016, USA
Pediatr Clin North Am 51:359-87. 2004..Because the most common causes of distortion or asymmetry are craniosynostosis or deformation, these abnormalities are the primary subjects of this article... - IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitisRobyn S Klein
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital East, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
J Immunol 172:550-9. 2004..Our data demonstrated that IP-10 was not required for the trafficking of pathogenic T cells into the CNS in EAE but played an unexpected role in determining the threshold of disease susceptibility in the periphery...
Research Grants
- Hedgehog, Patched, and Gli in MedulloblastomaHoward Weiner; Fiscal Year: 2007..This system provides a unique opportunity to investigate an in vivo animal model of childhood medulloblastoma, and to determine the roles of Ptc and Gli in tumorigenesis. ..