Research Topics
| Michael SchlameSummaryAffiliation: New York University Country: USA Publications
Research Grants
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Detail Information
Publications
Barth syndrome, a human disorder of cardiolipin metabolismMichael Schlame
Department of Anesthesiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
FEBS Lett 580:5450-5. 2006..Inhibition of this pathway leads to changes in mitochondrial architecture and function...- Molecular symmetry in mitochondrial cardiolipinsMichael Schlame
Department of Anesthesiology, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
Chem Phys Lipids 138:38-49. 2005..This limits the structural diversity of the cardiolipin species and creates molecular symmetry with implications for the stereochemistry of cardiolipin... - Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranesMichael Schlame
Department of Anesthesiology and Cell Biology, New York University School of Medicine, New York, NY 10016, USA
J Lipid Res 49:1607-20. 2008..Disturbances of cardiolipin metabolism are crucial in the pathophysiology of human Barth syndrome and perhaps also play a role in diabetes and ischemic heart disease... - Formation of molecular species of mitochondrial cardiolipin 2. A mathematical model of pattern formation by phospholipid transacylationMichael Schlame
Department of Anesthesiology, 550 First Avenue, New York University Langone Medical Center, New York, NY 10016, USA
Biochim Biophys Acta 1791:321-5. 2009..It is concluded that acyl-specific cardiolipin patterns could arise from phospholipid transacylations in the tafazzin domain, even if tafazzin itself does not have substrate specificity... - The role of cardiolipin in the structural organization of mitochondrial membranesMichael Schlame
Department of Cell Biology, NYU Langone Medical Center, New York, NY 10016, USA
Biochim Biophys Acta 1788:2080-3. 2009..e. the formation of uniformly substituted molecular species, may reduce the energy barrier of the assembly process... - Phospholipid abnormalities in children with Barth syndromeMichael Schlame
Department of Anesthesiology, New York University School of Medicine, New York, New York 10016, USA
J Am Coll Cardiol 42:1994-9. 2003..We sought to identify characteristic lipid abnormalities in patients with Barth syndrome (BTHS) and to correlate the lipid profile to phenotype and genotype... - A Drosophila model of Barth syndromeYang Xu
Department of Anesthesiology, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 103:11584-8. 2006..We conclude that a lack of full-length tafazzin is responsible for the cardiolipin deficiency, which is integral to the disease mechanism, leading to mitochondrial myopathy... - Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndromeAshim Malhotra
Department of Cell Biology, New York University Langone Medical Center, New York, NY 10016, USA
Proc Natl Acad Sci U S A 106:2337-41. 2009.... - Characterization of tafazzin splice variants from humans and fruit fliesYang Xu
Departments of Anesthesiology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 284:29230-9. 2009.... - Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid speciesAshim Malhotra
Department of Anesthesiology, New York University Langone Medical Center, New York, NY 10016, USA
Biochim Biophys Acta 1791:314-20. 2009.... - Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondriaDevrim Acehan
Skirball Institute, New York University Langone, Medical Center, New York, NY 10016, USA
Mitochondrion 9:86-95. 2009..The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation... - Characterization of lymphoblast mitochondria from patients with Barth syndromeYang Xu
Department of Anesthesiology, New York University School of Medicine, New York, NY 10016, USA
Lab Invest 85:823-30. 2005..The data suggest that phospholipid abnormalities of BTHS mitochondria led to partial uncoupling of oxidative phosphorylation and that lymphoblasts compensated for this deficiency by expanding the mitochondrial compartment... - Deficiency of tetralinoleoyl-cardiolipin in Barth syndromeMichael Schlame
Department of Anesthesiology, Hospital for Special Surgery, New York, NY, USA
Ann Neurol 51:634-7. 2002..Tetralinoleoyl-cardiolipin is specifically enriched in normal skeletal muscle and the normal heart. These findings support the notion that Barth syndrome is caused by alterations of mitochondrial lipids... - The enzymatic function of tafazzinYang Xu
Departments of Anesthesiology and Cell Biology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 281:39217-24. 2006..The data show that Drosophila tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine... - Cardiolipin affects the supramolecular organization of ATP synthase in mitochondriaDevrim Acehan
Department of Cell Biology, New York University School of Medicine, New York, New York, USA
Biophys J 100:2184-92. 2011..These data suggest that cardiolipin promotes the ribbonlike assembly of ATP synthase dimers and thus affects lateral organization and morphology of the crista membrane... - Remodeling of cardiolipin by phospholipid transacylationYang Xu
Department of Anesthesiology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 278:51380-5. 2003..The data suggest that CL is remodeled by acyl specific phospholipid transacylation and that tafazzin is an acyltransferase involved in this mechanism... - Comparison of lymphoblast mitochondria from normal subjects and patients with Barth syndrome using electron microscopic tomographyDevrim Acehan
Skirball Institute and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Lab Invest 87:40-8. 2007..The data suggest that mitochondrial abnormalities of BTHS involve adhesions of inner mitochondrial membranes with subsequent collapse of the intracristae space... - Disease-specific remodeling of cardiac mitochondria after a left ventricular assist devicePaul M Heerdt
Department of Anesthesiology, Weill Medical College at Cornell University and the Hospital for Special Surgery, New York, New York, USA
Ann Thorac Surg 73:1216-21. 2002..Failing hearts can exhibit elements of structural and molecular "reverse remodeling" after support with a left ventricular assist device (LVAD). The present study examined LVAD-induced remodeling of cardiac mitochondria... - Evaluation of aromatherapy in treating postoperative pain: pilot studyJung T Kim
Department of Anesthesiology, New York University Medical Center, New York 10016, USA
Pain Pract 6:273-7. 2006..Postoperative lavender oil aromatherapy did not significantly affect pain scores. However, patients in the lavender group reported a higher satisfaction rate with pain control than patients in the control group (P = 0.0001)... - Assays of cardiolipin levelsMichael Schlame
Department of Anesthesiology, New York University School of Medicine, New York, NY 10016, USA
Methods Cell Biol 80:223-40. 2007 - Binding of 10-N-nonyl acridine orange to cardiolipin-deficient yeast cells: implications for assay of cardiolipinVishal M Gohil
Department of Biological Science, Wayne State University, Detroit, MI 48202, USA
Anal Biochem 343:350-2. 2005 - Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependentVishal M Gohil
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
J Biol Chem 279:42612-8. 2004..This is the first report of regulation of phospholipid biosynthesis by alteration of subcellular compartment pH... - Vitamin E deficiency reduces surfactant lipid biosynthesis in alveolar type II cellsFlorian Guthmann
Clinic of Neonatology, , , Berlin, Germany
Free Radic Biol Med 34:663-73. 2003..Vitamin E depletion reduced the two pathways of PL synthesis and caused a decrease of PL content in alveolar surfactant of rats... - Bioactive oxidized lipids in the plasma of cardiac surgical intensive care patientsBettina Frey
Department of Anesthesiology and Intensive Care Medicine, University Hospital Charite, Humboldt University, Berlin, Germany
Shock 18:14-7. 2002..The data suggest that oxidatively modified lipids do not accumulate in patients with SIRS and MOF, perhaps because enhanced peroxidation of lipids is offset by enhanced lipolytic activity... - Cellular cholesterol stimulates acute uptake of palmitate by redistribution of fatty acid translocase in type II pneumocytesIngrid Kolleck
University Hospital Charite, Department of Neonatology, Humboldt Universitat, D 10098 Berlin, Germany
Biochemistry 41:6369-75. 2002....
Research Grants
- Molecular Mechanism of Barth SyndromeMichael Schlame; Fiscal Year: 2007..Such information may be useful for the development of new therapeutic approaches to cardiomyopathy and skeletal muscle disease. ..