Research Topics
Genomes and Genes | Caroline OjaimiSummaryAffiliation: New York Medical College Country: USA Publications
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Publications
Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strainGuiqing Wang
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
J Infect Dis 186:782-91. 2002..burgdorferi isolate. The RST1 genotype is genetically homogeneous and thus may represent a recently evolved clonal lineage that is highly pathogenic in humans and animals...- Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotypeCaroline Ojaimi
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 289:H1399-407. 2005..In conclusion, age- and genotype-related exercise limitations in maximal work performed and maximal running distance in male eNOS-KO mice indicated that fetal phenotype and age were related to onset of heart failure... - Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolismCaroline Ojaimi
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Cardiovasc Diabetol 9:43. 2010..The goal of this study was to investigate changes in cardiac gene expression in a canine model of alloxan-induced type 1 diabetes... - Altered expression of a limited number of genes contributes to cardiac decompensation during chronic ventricular tachypacing in dogsCaroline Ojaimi
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Physiol Genomics 29:76-83. 2007.... - Potential mechanisms of low-sodium diet-induced cardiac disease: superoxide-NO in the heartNobuhiro Suematsu
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circ Res 106:593-600. 2010..Patients on a low salt (LS) diet have increased mortality... - Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arraysCaroline Ojaimi
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Infect Immun 71:1689-705. 2003..These findings underscore the important role plasmid-encoded genes may play in adjustment of B. burgdorferi to growth under diverse environmental conditions... - Roles of CYP2C29 and RXR gamma in vascular EET synthesis of female miceDong Sun
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Regul Integr Comp Physiol 298:R862-9. 2010.... - Coronary nitric oxide production controls cardiac substrate metabolism during pregnancy in the dogJeffrey G Williams
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2516-23. 2008..The increase in endothelium-derived NO during pregnancy results in a tonic inhibition of glucose oxidation and reliance on FFA uptake and oxidation to support ATP synthesis in conjunction with upregulation of FFA metabolic enzymes... - Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heartSachin A Gupte
Department of Physiology, BSB Room 626, New York Medical College, Valhalla, 10595, USA
J Mol Cell Cardiol 41:340-9. 2006..We conclude that the activation of myocardial G6PD is a novel mechanism that enhances NADPH availability and fuels superoxide-generating enzymes in heart failure... - Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stressNobuhiro Suematsu
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circulation 115:255-62. 2007..However, little is known of the impact of HHcy on cardiac function and especially myocardial metabolism... - Comparative transcriptional profiling of Borrelia burgdorferi clinical isolates differing in capacities for hematogenous disseminationCaroline Ojaimi
Department of Microbiology and Immunology, New York Medical College, Valhalla, 10595, USA
Infect Immun 73:6791-802. 2005..burgdorferi clinical isolates that may provide clues to pathogenesis. The 78 ORFs identified here are a good starting point for the investigation of factors involved in the hematogenous dissemination of B. burgdorferi... - COX-2 contributes to the maintenance of flow-induced dilation in arterioles of eNOS-knockout miceDong Sun
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 291:H1429-35. 2006..Immunohistochemical staining confirmed the presence of COX-2 in the endothelium of eNOS-KO arterioles. In conclusion, COX-2-derived PGs are the mediators responsible for maintenance of FID in arterioles of eNOS-deficient mice... - Premature death and age-related cardiac dysfunction in male eNOS-knockout miceWei Li
Department of Physiology, New York Medical College, Valhalla, NY, USA
J Mol Cell Cardiol 37:671-80. 2004..These results indicate that male (-/-) mice have a significantly shorter lifespan than (+/+) or female mice, and male (-/-) mice develop cardiac dysfunction with age... - Cardiac structure and function in humans: a new cardiovascular physiology laboratorySu Song
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Adv Physiol Educ 33:221-9. 2009..This communication describes our experience in developing a new cardiovascular control laboratory to reinforce didactic material presented in lectures and small-group sessions... - Borrelia burgdorferi gene expression profiling with membrane-based arraysCaroline Ojaimi
Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA
Methods Enzymol 358:165-77. 2002 - Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespanArantxa Gonzalez
Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Circ Res 102:597-606. 2008..The senescent heart phenotype and heart failure are corrected to some extent, leading to prolongation of maximum lifespan...